DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a14 and Cyp317a1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	167/523 - (31%)
Similarity:	271/523 - (51%)	Gaps:	41/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFTIALVG-VVLGLAYSLHIKI---FSYWKRKGVPHETPLPIVGNMRGI---------VKKYHF 52
            |.....::| :||||...|.|..   ..||:...:|||.|..:...:|.|         :|..|:
  Fly     1 MWIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHY 65

  Fly    53 RDINQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHL 117
                ..|||||||.||..|.|...:..|||.|.:.|:|:|||||..|.|||.:.|.:.|||:|.|
  Fly    66 ----SAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDL 126

  Fly   118 FALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARF 182
            :||.||.|:.||.||.|.....::..:...:.:...:|...::..:...  ....|.|:.:..|:
  Fly   127 YALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQ--PHSTVHIQKIMRRY 189

  Fly   183 TTDVIGSCAFGLECNSLQD-PSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDL 246
            ....:..|.|||.....:. |..:|.|.........:|..|:...:.......|.||::..|...
  Fly   190 VLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQA 254

  Fly   247 TQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAED----QEAAKKGQGIDLSHGLTLEQMAAQA 307
            .::|:..:.:.|:.|..:|..:.|:::.:|:::|.:    |..|.|..|..|.:     ::||.|
  Fly   255 EEYFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQN-----ELAAHA 314

  Fly   308 FVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSE 372
            .||..||:|.:::|:|..||||||.|::|.|:|||::..:...| |.:.::.:..::::.||::|
  Fly   315 VVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHD-GHITHEGIKSLSFMGQVINE 378

  Fly   373 TLRKHPLLPHLIRETTKDYQIP-NSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEV 436
            |||.||:.|:::|.|..||.:| :...:|.|.:..:||.|.|||||:|||:||:|.|.|:.....
  Fly   379 TLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRD 443

  Fly   437 KNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDG 501
            ..:....:..||.|.|:|||::|.::|.::.|..||..::||::.|.  |||        ...||
  Fly   444 SLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRK--PLI--------NLEDG 498

  Fly   502 IYL 504
            |.|
  Fly   499 IAL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	157/488 (32%)
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	139/438 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070