DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a14 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	170/540 - (31%)
Similarity:	264/540 - (48%)	Gaps:	63/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGN-----MRG---IVKKYHFRDINQR 58
            :..:||..::|.|.|...:..:..:..:||.||.|.|::||     |.|   ::||.      ..
  Fly     5 MIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKM------IE 63

  Fly    59 IYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAF-TNPRDDPLTGHLFALEG 122
            ::.|..| .|:.|:|........:.|.:.||.:.||:|.:|.:..:. .|.::..|:..|.:|..
  Fly    64 LHTKHTG-SPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRD 127

  Fly   123 EEWRAMRHKLTPVFTSGKIKQMSKVIVDVG----LRLGDAMDKAVKEAKVEEGNVEIKDLCARFT 183
            ..|:.||:.|||.||..|::.|..:|....    :.:.:.::.: ::|.:|   :|:||...||.
  Fly   128 GRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELS-QDASIE---LEMKDYFTRFA 188

  Fly   184 TDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNA-------RLARKLRIKV 241
            .|||.:.|||:..||       ||:|..|.|...:..:.:.::....|       ||.:.|||:|
  Fly   189 NDVIATVAFGISINS-------FRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQV 246

  Fly   242 LPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLS---------HG 297
            |......:|.|.|...:.||.::.:.|.|.|..::|        ||:.:..|||         ..
  Fly   247 LDTKNIDYFSSLVTAAMRYRQEHKVVRPDMIHLLME--------AKQQRLADLSDKSKDELYYSE 303

  Fly   298 LTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQ 362
            .|.:.:.||..:||.||||..||::....:||.|.|.:|.||.|||.||...:.|..|.||.|.:
  Fly   304 FTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTK 368

  Fly   363 MTYLDQVLSETLRKHPLLPHLIRETTKDYQI--PNSDIVLD--KGILALIPVHNIHHDPEIYPEP 423
            |.|||.|:.|.|||.|......||..:|..:  .|...:..  ||.:..||:.::|||||.:.:|
  Fly   369 MKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDP 433

  Fly   424 EKFDPSRF-DPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPL 487
            |.|:|.|| |...:::|   .|:|||.|||||||.|...::.|..:..||..||...:.||...|
  Fly   434 EFFNPERFADGHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDL 495

  Fly   488 IFSKKSFLLTTNDGIYLKVE 507
            :...:...|...:|.:||.|
  Fly   496 LNDIRGHGLKPKNGFWLKFE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	161/507 (32%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	158/502 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970