DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	192/519 - (36%)
Similarity:	303/519 - (58%)	Gaps:	25/519 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRG-IVKKYHFRDINQRIYKK--F 63
            :..:.|:|.:..:.|....:..|:|:|.||.:..|.|:||..|. :..|..|.:..|:.::.  |
  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGF 65

  Fly    64 KGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGH--LFALEGEEWR 126
            :.: |..|:||..:...:|.||:.||.||||.|.||.:|...|:|.:|.| |:  ||......||
  Fly    66 ENE-PFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDAL-GYKNLFFARSPGWR 128

  Fly   127 AMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCA 191
            .:|.|::|||||||||||..::|.:|..|.|:.::.....:     |::||||:|||||:|.:.|
  Fly   129 ELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTE-----VQVKDLCSRFTTDLIATIA 188

  Fly   192 FGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVKN 256
            ||:|.|:|||..:||....|.||:......:..:.||....||...|:|:...:.|:|..|:|..
  Fly   189 FGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNY 253

  Fly   257 TVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSST 321
            .:..|.:.|.||||.|:.::.|:.|  .||..|:   :|..:.|:.:.|||.||..||||||:||
  Fly   254 VLKERERTGEKRNDLIDILLALKRE--AAANPGK---MSKEVDLDYLVAQAAVFQTAGFETSAST 313

  Fly   322 MSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRE 386
            |::.|||||....:|.|||:||.....:.|  .::|:.:.:|.||.||::|||||:|::.::.||
  Fly   314 MTMTLYELAKNEALQDRLRQEIVDFFGDED--HISYERIQEMPYLSQVVNETLRKYPIVGYIERE 376

  Fly   387 TTKDYQ------IPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYL 445
            .::..:      .|..::.|..|:...:....:|.||:.:|:|||:||.||:.....|.:..||:
  Fly   377 CSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYM 441

  Fly   446 PFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVERV 509
            |||.|||||||:|.|.:|:|:|||.:||..:|...::|...:.::..|.::.:...|.|:||:|
  Fly   442 PFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRVEKV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	181/484 (37%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	180/480 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
	10	10.000