DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp310a1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_609891.1	Gene:	Cyp310a1 / 35115	FlyBaseID:	FBgn0032693	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	128/523 - (24%)
Similarity:	253/523 - (48%)	Gaps:	64/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVGVVLGLAYSLHIK-IFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDIN--QRIYKKFK-GQG 67
            |:.::|..|..|.:: |:|:|:|:|.|.|.    .|.....::|.:.|:..  :.|.:.:: |:.
  Fly     4 LLPILLYSAVFLSVRHIYSHWRRRGFPSEK----AGITWSFLQKAYRREFRHVEAICEAYQSGKD 64

  Fly    68 PIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGH-LFALEGEEWRAMRHK 131
            .:.|:|.||:...|:.:::..:.::      .|..|.|:..:.|.::|: .|.|        ..|
  Fly    65 RLLGIYCFFRPVLLVRNVELAQTIL------QQSNGHFSELKWDYISGYRRFNL--------LEK 115

  Fly   132 LTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEG-----NVEIKDLCARFTTDVIGSCA 191
            |.|:|.:.::.:|...:..||       |..:......:|     .|:|:.....::.::|.:..
  Fly   116 LAPMFGTKRLSEMFGQVQKVG-------DHLIHHLLDRQGQGCPQEVDIQQKLRVYSVNIIANLI 173

  Fly   192 FGLECNSLQDPSAEFRQKGREIFTRRRHS-TLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVK 255
            :||:.|:       |..:...:.:...|| ..:||  ||..||.:|       ...|......:|
  Fly   174 YGLDINN-------FEHEDHILTSYLSHSQASIQS--FTLGRLPQK-------SSYTYRLRDLIK 222

  Fly   256 NTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHG---LTLEQMAAQAFVFFVAGFET 317
            .:|:.|..:|:.|.|.::.::..|..::.:..|.|...::..   |:::::|..|........:.
  Fly   223 QSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSIKRLAKVAEDLLKVSLDA 287

  Fly   318 SSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPH 382
            .:||::..|.|:..:|.|.::||.||:. |:| :.|:|.::.|..:.|:|..|.|||||:|.||.
  Fly   288 VASTVTFTLLEILQEPLIVEKLRAEIKE-LSN-ENGQLKFEELNGLRYMDMCLKETLRKYPPLPI 350

  Fly   383 LIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRF-----DPEEVKNR-HP 441
            :.|...|.|.:|||...:|:|...::|:..:|.|.:.:.||.|:.|.||     |..:.::: ..
  Fly   351 IERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFLQTANDVGQCEDKTKS 415

  Fly   442 MAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSV-SNRTDVPLIFSKKSFLLTTNDGIYLK 505
            ..::.||.|...|:|..|.|:..|:.|:.||:.|...: :|:.....:..:.:..:.|.||:.:|
  Fly   416 NVFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNFHLELDANQVKTLKVSHRPAPFIHTKDGLKVK 480

  Fly   506 VER 508
            ::|
  Fly   481 LKR 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	117/493 (24%)
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	105/423 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	5	5.020