DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	526	Identity:	168/526 - (31%)
Similarity:	272/526 - (51%)	Gaps:	61/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNM----RGIVKKYHFRDINQRIYKK 62
            |.|:.|:.::|.|.|....:....:|::|:|...|||.:|.:    .||.|      .:...|:|
Mouse     9 LDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYTGIWK------FDMECYEK 67

  Fly    63 -------FKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTG----H 116
                   |.||.|:          .:|||.:.||.|::||.     ...|||.|:....|    .
Mouse    68 YGKTWGLFDGQTPL----------LVITDPETIKNVLVKDC-----LSVFTNRREFGPVGIMSKA 117

  Fly   117 LFALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEG-NVEIKDLCA 180
            :...:.|||:..|..|:|.||||::|:|..||.    :.||.:.|.::: :.|:| .|.:||:..
Mouse   118 ISISKDEEWKRYRALLSPTFTSGRLKEMFPVIE----QYGDILVKYLRQ-EAEKGMPVAMKDVLG 177

  Fly   181 RFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIF--TNARLARKLRIKVLP 243
            .::.|||.|.:||:..:||.:|...|.::.::.........|:.|.:.  ....:...|.|.:.|
Mouse   178 AYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFP 242

  Fly   244 DDLTQFFMSTVKNTVDYRLKNGIK-RNDFIEQMIEL--RAEDQEAAKKGQGIDLSHGLTLEQMAA 305
            :|..:||...|....:.||.:..| |.||::.|:..  .::|:::.|....::::         .
Mouse   243 NDSIEFFKKFVDRMQESRLDSNQKHRVDFLQLMMNSHNNSKDKDSHKAFSNMEIT---------V 298

  Fly   306 QAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVL 370
            |:.:|..||:||:|||:|..||.||..||||::|:.||:..|.|  ......|.:.:|.|||.||
Mouse   299 QSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPN--KATPTCDTVMEMEYLDMVL 361

  Fly   371 SETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEE 435
            :||||.:|::..|.|...||.::  :.:.:.||.:.:||.:.:||||:.:|:||:|.|.||..|.
Mouse   362 NETLRLYPIVTRLERVCKKDVEL--NGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKEN 424

  Fly   436 VKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTND 500
            ..:..|..|||||.|||||||:||..:..|:.:..:|:.|.|.....|.:||..|::. :|....
Mouse   425 KGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQG-ILQPEK 488

  Fly   501 GIYLKV 506
            .|.|||
Mouse   489 PIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	158/494 (32%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	158/494 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850