DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	145/529 - (27%)
Similarity:	243/529 - (45%)	Gaps:	57/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIV--KKYHFRDINQRIYKKFK 64
            ||.||   .:|.|.|......|||||::|:|.....|.||:...:.  |:....||:: ||:::|
  Fly     8 LFVIA---AILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDE-IYEQYK 68

  Fly    65 GQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDR--GAFTNPRDDP-LTGHLFALEGEEWR 126
            ....|.|::.......::|..::..::.:.||..|.|.  ..||:.:.|| |..:.|.|.||.|:
  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWK 133

  Fly   127 AMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCA 191
            ..|.::||..::.::|....|.:.|..:..:.:.:....|..:  .:..||||..:||:||..|.
  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQ--GLNAKDLCLCYTTEVISDCV 196

  Fly   192 FGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKL--------RIKVLPDDLTQ 248
            .|:...|..|.........:.:|.        |||.|....:...|        .:.:...|:..
  Fly   197 LGISAQSFTDNPTPMVGMTKRVFE--------QSFGFIFYTVVANLWPPITKFYSVSLFAKDVAA 253

  Fly   249 FFMSTVKNTVDYRLKN--GIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFF 311
            ||...::..:..|.::  ..:|:||:..|::|    ||  ||        ||...::.:....|.
  Fly   254 FFYDLMQKCIQVRRESPAAQQRDDFLNYMLQL----QE--KK--------GLNAAELTSHTMTFL 304

  Fly   312 VAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRK 376
            ..||||::..::..|..||..|..|.:|||||.:       .||.::.::::.:.:..:.||||.
  Fly   305 TDGFETTAQVLTHTLLFLARNPKEQMKLREEIGT-------AELTFEQISELPFTEACIHETLRI 362

  Fly   377 HPLLPHLIRETTKDYQIPNSD---IVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRF---DPEE 435
            ...:....:..|:..::.|.:   :.|..|.:.:|||:.:||||:.|.||:.|.|.||   :...
  Fly   363 FSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGA 427

  Fly   436 VKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTND 500
            .|.|....:..||||||.|.|:||...|.|..||.::|.|...|:.:|..........|:.....
  Fly   428 KKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALKG 492

  Fly   501 GIYLK-VER 508
            |::|. |||
  Fly   493 GVWLDFVER 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	129/495 (26%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	126/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	7	7.070