DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	171/518 - (33%)
Similarity:	273/518 - (52%)	Gaps:	25/518 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFTIALVG---VVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVK-KYHFRDINQRIYK 61
            :|..:.|.|   :|:.:.:...|..|.:|:|.|||.....|.|||:..::: ...|.|..:.:|:
  Fly    18 VLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYE 82

  Fly    62 KFKGQG-PIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPL-TGHLFALEGEE 124
            ..:..| ...|:.:......|:.|...||::|::||:.|..|...|:|..|.: :.:||..:.|.
  Fly    83 SKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYET 147

  Fly   125 WRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGS 189
            ||.......|.|.:||::.|..::.::|.:|.:.|::  |.:..:...:|:|.|||.||||:|.|
  Fly   148 WRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQ--KLSGRDSMELEVKQLCALFTTDIIAS 210

  Fly   190 CAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTV 254
            .|||:|.:|||:|.||||:...|:...|....|....:|...||:.::...:..::..:|...::
  Fly   211 LAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERFMRKSM 275

  Fly   255 KNTVDYRLKNGIKRNDFIEQMIEL-RAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETS 318
            ...:..|.::|..|:|.|:..::| |.|..|:        :.|  ..:..||||....:|||:||
  Fly   276 DYVLSQRAESGENRHDLIDIFLQLKRTEPAES--------IIH--RPDFFAAQAAFLLLAGFDTS 330

  Fly   319 SSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHL 383
            |||::..|||||....||.|||.|:.:.|.:....:|:.|.:..:.||.||:.|.||.:|....|
  Fly   331 SSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFL 395

  Fly   384 IR--ETTKDYQIP----NSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPM 442
            .|  .:...|.:.    .|...|..|....|.|..||.|.:.:|.||.|||.||..|:.:..|||
  Fly   396 DRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPM 460

  Fly   443 AYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLK 505
            .|||||.|||.|||...|:::.|:||:.:|..|:..|..||...:.|..|:|:||.::|.||:
  Fly   461 TYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	161/484 (33%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	147/435 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070