Protein Alignment Cyp6a14 and Cyp3a2

DIOPT Version :9

• Sequence 1: NP_001286199.1
• Gene: Cyp6a14 / 35835
• FlyBaseID: FBgn0033302
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_695224.3
• Gene: Cyp3a2 / 266682
• RGDID: 708379
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 176/529 - (33%)
• Similarity: 274/529 - (51%)
• Gaps: 67/529 - (12%)

  Fly     2 LFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNM----RGI-------VKKYHFRDI 55
            |.|..|:.|:|.|.|.|.......:|::|:|...|||.:|.:    :|:       .|||
  Rat     9 LETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYKGLGRFDMECYKKY----- 68

  Fly    56 NQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDPLTG---- 115
             .:|:..|.||.|:..          |.|.:.||.|::|: ||      .|||.||....|
  Rat    69 -GKIWGLFDGQTPVFA----------IMDTEMIKNVLVKECFS------VFTNRRDFGPVGIMGK 116

  Fly   116 HLFALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGN-VEIKDLC 179
            .:...:.|||:..|..|:|.||||::|:|..:|.    :.||.:.|.:|: :.|.|. |.:|.:.
  Rat   117 AVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIE----QYGDILVKYLKQ-EAETGKPVTMKKVF 176

  Fly   180 ARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREI-----FTRRRHSTLVQSFIFTNARLARKLRI 239
            ..::.|||.|.:||:..:||.:|...|.:|.:::     |.....|.::..|:   ..:...|.|
  Rat   177 GAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFL---TPIYEMLNI 238

  Fly   240 KVLPDDLTQFFMSTVKNTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSH-GLTLEQ 302
            .:.|.|...||...|....:.||.:..| |.||::.|:......::        ::|| .|:..:
  Rat   239 CMFPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKD--------EVSHKALSDVE 295

  Fly   303 MAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLD 367
            :.||:.:|..||:||:|||:|..||.||..||||::|:|||:..|.:  .....||::.:|.|||
  Rat   296 IIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPS--KAPPTYDIVMEMEYLD 358

  Fly   368 QVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFD 432
            .||:||||.:|:...|.|...||.::  ..:.:.||.:..||.:.:||||:.:|:||:|.|.||.
  Rat   359 MVLNETLRLYPIGNRLERVCKKDIEL--DGLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFS 421

  Fly   433 PEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLT 497
            .|...:..|..|||||:|||||||:||..:..|:.|..:|:.|.|.....|.:||..|::: :|.
  Rat   422 KENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQA-ILE 485

  Fly   498 TNDGIYLKV 506
            ....|.|||
  Rat   486 PEKPIVLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	164/497 (33%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	156/468 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870