DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a14 and erg5

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	545	Identity:	122/545 - (22%)
Similarity:	229/545 - (42%)	Gaps:	105/545 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FTIALVGVVLGLAYSLHIKIFSYWKRKG-VP-HETPLPIVGNMRGIVKKYHFRDINQRIYKKFKG 65
            :||....:.:.:||..    .||..:|| :| ....:|.:|:         |.|..:..::|:..
pombe    29 WTICFALLAVCIAYDQ----ISYQMQKGHIPGPRFKIPFMGS---------FLDSMKPTFEKYNA 80

  Fly    66 Q---GPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRA 127
            :   ||::.:.:|.|...:.::.|..::: :...||.|........:....|..:| |:|.:...
pombe    81 KWQTGPLSCVSVFHKFVVIASERDLARKI-LNSPSYVQPCVVDAGKKILKHTNWVF-LDGRDHIE 143

  Fly   128 MRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARF---------T 183
            .|..|..:||:..:......            .:||.....:|.....||..|::         .
pombe   144 YRKGLNGLFTTRALASYLPA------------QEAVYNKYFKEFLAHSKDDYAQYMIPFRDINVA 196

  Fly   184 TDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQ 248
            |.....|.:.:..::::..:.|:.:             :..:....|..:       |||.....
pombe   197 TSCRTFCGYYISDDAIKHIADEYWK-------------ITAAMELVNFPI-------VLPFTKVW 241

  Fly   249 FFMSTVKNTVDYRLKNGI--KRN------------DFIEQMIELR---AEDQEAAKKGQGIDLSH 296
            :.:.:.|..:.|.:|...  ::|            ::|.:|||.|   :|::|.|:|..  .|..
pombe   242 YGIQSRKVVMRYFMKAAAESRKNMEAGNAPACMMEEWIHEMIETRKYKSENKEGAEKPS--VLIR 304

  Fly   297 GLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLA 361
            ..:.|:::.....|..|..:.:||.|:.....||..||:.|::|||...:........|:.|::.
pombe   305 EFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPDVLQKVREEQLRIRKGDIDVPLSLDLME 369

  Fly   362 QMTYLDQVLSETLRKHP---LLPHLIRET---TKDYQIPNSDIVLDKGILALIP-VHNIHHDPEI 419
            :|||...|:.|.||..|   ::|:.:::.   |.||.:|...:|        || ::...||.::
pombe   370 KMTYTRAVVKECLRLRPPVLMVPYRVKKAFPITPDYTVPKDAMV--------IPTLYGALHDSKV 426

  Fly   420 YPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRF--GKIQAKIGLVSLLRRFKFSVSNR 482
            |||||.|:|.|:.|..:..:.|..::.||:||..|:|.|:  ..:.|.||..|::..:|...:..
pombe   427 YPEPETFNPDRWAPNGLAEQSPKNWMVFGNGPHVCLGQRYAVNHLIACIGKASIMLDWKHKRTPD 491

  Fly   483 TDVPLIFSKKSFLLTT--NDGIYLK 505
            :|..:||:      ||  .|..|||
pombe   492 SDTQMIFA------TTFPQDMCYLK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	114/515 (22%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	109/506 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100827
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	6	5.990