DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	157/504 - (31%)
Similarity:	264/504 - (52%)	Gaps:	49/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRD----INQRIYKKFK 64
            |..|:...|.|.|.........:|:.|:|...|:|:.|.:      :::.|    .:...|||:
  Rat    11 TWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTI------FNYGDGMWKFDDDCYKKY- 68

  Fly    65 GQGPIAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDPLTGHLFAL---EGEEW 125
              |.|.|.|...:....|.|.:.||.|::|: :|.|.:|..|     .|:.....|:   |.|||
  Rat    69 --GKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF-----GPMGFMKKAITMSEDEEW 126

  Fly   126 RAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSC 190
            :.:|..|:|.|||||:|:|..::    .:.||.:.|.::..:.:...:.:||:...::.|||...
  Rat   127 KRLRTILSPTFTSGKLKEMFPLM----RQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGT 187

  Fly   191 AFGLECNSLQDPSAEFRQKGR-----EIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFF 250
            :||:..:||.:|...|.||.:     :||.....|.::..|:   ..:...|...:.|.....||
  Rat   188 SFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFL---TPIYEMLNFSIFPRQSMNFF 249

  Fly   251 MSTVKNTVDYRLKNGIK-RNDFIEQMIELR-AEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVA 313
            ...||.....||.:..| |.||::.|:..: ::.||:.|         .|:..:|||||.:|...
  Rat   250 KKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQK---------ALSDLEMAAQAIIFIFG 305

  Fly   314 GFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHP 378
            |::.:|:::|..:||||.:|::|::|:.||:..|.|  ...:.||.|.:|.|||.|::|:||.:|
  Rat   306 GYDATSTSISFIMYELATRPNVQKKLQNEIDRALPN--KAPVTYDALMEMEYLDMVVNESLRLYP 368

  Fly   379 LLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMA 443
            :...|.|.:.||.:|  :.:.:.||.:..||::.:|.:||.:.|||:|:|.||..|...:..|..
  Rat   369 IATRLDRVSKKDVEI--NGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYV 431

  Fly   444 YLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKK 492
            |||||:|||||||:||..|..|:.::.:|:.|......:|.:||..|::
  Rat   432 YLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	150/476 (32%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	143/442 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870