DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	163/556 - (29%)
Similarity:	259/556 - (46%)	Gaps:	95/556 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQGP 68
            |:.|..|:|.|........||..::.|:.|..|.|.|||:  :..:..|.:.:..:.:::   ||
  Rat    17 TVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNL--MFFRQGFWESHLELRERY---GP 76

  Fly    69 IAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMRHKLT 133
            :.|.|:..:...:|:|.|.||:|::::||.|.:|.| :......:...:..|....|..:|..|.
  Rat    77 LCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMA-SGLEPKLIADSVLMLRDRRWEEVRGALM 140

  Fly   134 PVFTSGKIKQMSKVIVDV----------GLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIG 188
            ..|:..|:.:|:.:|...          ....|||.|              |:.....|||:|:.
  Rat   141 SAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFD--------------IQRCYCCFTTNVVA 191

  Fly   189 SCAFGLECNSLQDPSAEFRQKGREIF---TRRRHSTLVQSFIFTNARLARKLRIKVLP----DDL 246
            |.|||:|.||...|...|.|..:.:|   |.|....|:.||......|||     :||    |:|
  Rat   192 SVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLAR-----ILPNKNRDEL 251

  Fly   247 TQFFMSTVKNTVDYRLKNGI--KRNDFIEQMIELRAEDQEAAKKGQGID--------LSHG---- 297
            ..||.:.::|.:..|.|...  :|.||::.::     |.:.:....|::        ||..
  Rat   252 NGFFNTLIRNVIALRDKQTAEERRGDFLQMVL-----DAQRSMSSVGVEAFDMVTEALSSAECMG 311

  Fly   298 --------------LTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVL- 347
                          ||::::|.|||:|.:||.|.:::|:|...|.||..|:.|:||.:|::..:
  Rat   312 DPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFME 376

  Fly   348 -------ANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGIL 405
                   .|:..|         :.|||.|::||||.:|......||..:|.::....|  ..|.:
  Rat   377 KHPAPEYCNLQEG---------LPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHI--PAGSV 430

  Fly   406 ALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVS 470
            ..|.|..:|||||.:|.||.|||.||..|....:.|..|||||.|||:|:|:|.|.:..|:.|:.
  Rat   431 LEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQ 495

  Fly   471 LLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKV 506
            :|.:|:|.....|.|||....||.|...| |:|:|:
  Rat   496 VLHKFRFEACPETQVPLQLESKSALCPKN-GVYVKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	154/526 (29%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	153/524 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870