DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and cyp-13B2

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_510369.2	Gene:	cyp-13B2 / 187068	WormBaseID:	WBGene00010606	Length:	511	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	147/544 - (27%)
Similarity:	237/544 - (43%)	Gaps:	122/544 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQR-------IYKK 62
            :|::|||.|....:|    |||||:|:.....||.:|:         |.|:..|       |.|.
Worm     8 VAIIGVVAGYFKWIH----SYWKRRGIEGPVGLPFIGS---------FYDLADREKPRGFIINKW 59

  Fly    63 FKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDR-------GAFTNPRDDPLTGHLFAL 120
            .|..|.:.|.|.......:::|||.::::.||.|..|..|       |.....:::|.. :|||.
Worm    60 TKMFGKVFGYYEGVIPVLVVSDLDMLQEMFIKKFDCFYARKTTNLIHGNLECSQEEPRV-NLFAA 123

  Fly   121 EGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVK-EAKVEEGNVEIKDLCARFTT 184
            .|..|:.:|...:|.|:...:||:.:.:.|....:.|.|.|.|. ||      ..|.:....||.
Worm   124 RGARWKRLRALASPAFSVKALKQIHETMEDSVFSMVDHMSKQVNGEA------FNIHEYYQEFTY 182

  Fly   185 DVIGSCAFGLECNSLQDPSAEFRQKG----REIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDD 245
            |||...|.|      |..|.:|..:|    ::||.|:.                     :|.|..
Worm   183 DVISRLAMG------QTYSEQFNNEGVDIVKKIFLRKN---------------------RVYPWY 220

  Fly   246 LTQF---FMSTVKNT----------------------VDYRLK-------NGIK--RNDFIEQMI 276
            |...   |.:|:|||                      |..|||       .||:  .||||:..:
Worm   221 LAVMFPGFENTIKNTFFNHEAVRGGDVGKLLKFCETAVHDRLKERADNVEQGIENPHNDFIDMFL 285

  Fly   277 ELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLRE 341
            :... |........||.:...:|.|.:....|||.:|||:|:::|::...|.||..|...:::::
Worm   286 DYYT-DTNIEDNAFGIKVEKKVTSEDVIGACFVFLLAGFDTTANTLAYASYLLAKHPQEMRKVQD 349

  Fly   342 EIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLL-----PHLIRETTKDYQIPNSDIVLD 401
            ||:.:..:   ..::||.:.::.|:|.|:.|.||.:|:.     ...::.||.      .:..::
Worm   350 EIDRICTS---EHISYDDIGKLRYMDAVIREALRMYPVAWFACSRECVQATTL------GNYYIE 405

  Fly   402 KGILALIPVHNIHHDPEIYPEPEKFDPSRFDPE---EVKNRHPMAYLPFGDGPRNCIGLRFGKIQ 463
            ||:.....|..:|:..||:.:    :.:.|.||   |...||.|:::|||.|||.|:|:|.|..:
Worm   406 KGVRIEADVRALHYSEEIWGK----NANEFVPERWLESSPRHNMSWIPFGAGPRQCVGMRLGLSE 466

  Fly   464 AKIGLVSLLRRFKFSVSNRTDVPL 487
            ||..|..|||||......:|:..|
Worm   467 AKTALAHLLRRFSILAGPKTEKEL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	135/517 (26%)
cyp-13B2	NP_510369.2	p450	32..490	CDD:278495	134/514 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	171	1.000	Domainoid score	I2249
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134304
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28638
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm4759
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830