DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a14 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	172/512 - (33%)
Similarity:	271/512 - (52%)	Gaps:	42/512 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQGPI 69
            :.::.:||...|..|  ....:|:.|:|...|||.:|.:  :..:..|.:.::..:||:   |.:
  Rat    14 LLVISLVLLYLYGTH--SHGIFKKLGIPGPKPLPFLGTI--LAYRKGFWEFDKYCHKKY---GKL 71

  Fly    70 AGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHL----FALEGEEWRAMRH 130
            .|:|...:....|||.|.||.|::|: .|    ..|||.|:....|.|    ...|.|||:.:|.
  Rat    72 WGLYDGRQPVLAITDPDIIKTVLVKE-CY----STFTNRRNFGPVGILKKAISISEDEEWKRIRA 131

  Fly   131 KLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLE 195
            .|:|.|||||:|:|..:|    .:..|.:.:.:::...|.....:||:...::.|||.:.:||:.
  Rat   132 LLSPTFTSGKLKEMFPII----NQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVN 192

  Fly   196 CNSLQDPSAEFRQKGR-----EIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVK 255
            .:||.:|...|.:|.:     :||.....|..:..|:   ..|...|.:.:.|.|:..||.::|:
  Rat   193 VDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFL---TPLFEALNVSMFPRDVIDFFKTSVE 254

  Fly   256 NTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSS 319
            ...:.|:|...| |.||::.||    ..|.:..|    |....|:..::.||:.:|..||:||:|
  Rat   255 RMKENRMKEKEKQRMDFLQLMI----NSQNSKVK----DSHKALSDVEIVAQSVIFIFAGYETTS 311

  Fly   320 STMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLI 384
            |.:|..||.||:.||||::|::||::.|.|  .....||.|.||.|||.|::||||.:|:...|.
  Rat   312 SALSFVLYLLAIHPDIQKKLQDEIDAALPN--KAHATYDTLLQMEYLDMVVNETLRLYPIAGRLE 374

  Fly   385 RETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGD 449
            |....|.:|  :.:.:.||.:.:||...:|.||..:||||:|.|.||..:...|.:|..|||||:
  Rat   375 RVCKTDVEI--NGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGN 437

  Fly   450 GPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKV 506
            |||||||:||..:..|:.||.:|:.|.|.....|.:||..||:. ||.....:.|||
  Rat   438 GPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQG-LLQPEKPLLLKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	164/483 (34%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	164/483 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870