Protein Alignment Cyp6a14 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_610389.3
• Gene: Cyp6a14 / 35835
• FlyBaseID: FBgn0033302
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 124/545 - (22%)
• Similarity: 207/545 - (37%)
• Gaps: 146/545 - (26%)

  Fly     2 LFTIALVGVVLGLAYSL-HIKIFSYWKRKGVPHETPLPIVGNMRG----------IVKKYHFRDI 55
            |...||...||.|...| .||::..:...|......||:.....|          ::::..|..:
Human     6 LLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQM 70

  Fly    56 NQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFAL 120
            .:|.|      |.|...::|.:.|..:...|.::::::.:                      ..|
Human    71 KRRKY------GFIYKTHLFGRPTVRVMGADNVRRILLGE----------------------HRL 107

  Fly   121 EGEEWRAMRHKLTPVFTSGKI--------KQMSKVIVDVGLRLGDAMDKAVKEAKVEEGN----- 172
            ....|.|   .:..:..||.:        ||..|||:....|  :|::..|.....|.|:
Human   108 VSVHWPA---SVRTILGSGCLSNLHDSSHKQRKKVIMRAFSR--EALECYVPVITEEVGSSLEQW 167

  Fly   173 -----------VEIKDLCARFTTDVIGSCAFGL--ECNSLQDPSAEFRQKGREIFTRRRHSTLVQ 224
                       .|:|.|..|....::..|...|  :.:|.|.....|.:..|.:|:
Human   168 LSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFS--------- 223

  Fly   225 SFIFTNARLARKLRIKVLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIE--LRAE--DQEA 285
                             ||.|:.  |..         |..|:|..:.|...||  :||:  ...|
Human   224 -----------------LPIDVP--FSG---------LYRGMKARNLIHARIEQNIRAKICGLRA 260

  Fly   286 AKKGQG------IDLSHG------LTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQR 338
            ::.|||      :.:.|.      |.::.:...:......|.||::|..:..:..|.|.|.:.|:
Human   261 SEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQK 325

  Fly   339 LREEIES----VLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTK-----DYQIP 394
            :|||::|    ..:|.| .:|:.::|.|:.|:..|:.||||.:|.:|...|...|     .||||
Human   326 VREELKSKGLLCKSNQD-NKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIP 389

  Fly   395 NSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRF---DPEEVKNRHPMAYLPFGDGPRNCIG 456
                   ||...:..:.:.|...||:...|:|:|.||   .||:...   .:::|||.|.|:|:|
Human   390 -------KGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASR---FSFIPFGGGLRSCVG 444

  Fly   457 LRFGKIQAKIGLVSLLRRFKFSVSN 481
            ..|.||..||..|.|.|...:.:.|
Human   445 KEFAKILLKIFTVELARHCDWQLLN 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_610389.3	CYP6-like	65..503	CDD:410679	108/471 (23%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	111/496 (22%)