DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a14 and CYP3A4

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens

Alignment Length:	518	Identity:	180/518 - (34%)
Similarity:	274/518 - (52%)	Gaps:	48/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYH--FRDINQRIYKKFKGQ 66
            |..|:.|.|.|.|.........:|:.|:|..||||.:||    :..||  |...:...:||:
Human    11 TWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGN----ILSYHKGFCMFDMECHKKY--- 68

  Fly    67 GPIAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDP---LTGHLFALEGEEWRA 127
            |.:.|.|...:....|||.|.||.|::|: :|.|.:|..|     .|   :...:...|.|||:.
Human    69 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDEEWKR 128

  Fly   128 MRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGN-VEIKDLCARFTTDVIGSCA 191
            :|..|:|.|||||:|:|..:|.    :.||.:.:.::. :.|.|. |.:||:...::.|||.|.:
Human   129 LRSLLSPTFTSGKLKEMVPIIA----QYGDVLVRNLRR-EAETGKPVTLKDVFGAYSMDVITSTS 188

  Fly   192 FGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNA-----RLARKLRIKVLPDDLTQFFM 251
            ||:..:||.:|...|.:..:::.   |...|...|:....     .:...|.|.|.|.::|.|..
Human   189 FGVNIDSLNNPQDPFVENTKKLL---RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250

  Fly   252 STVKNTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSH-GLTLEQMAAQAFVFFVAG 314
            .:||...:.||::..| |.||::.||     |.:.:|:.:    || .|:..::.||:.:|..||
Human   251 KSVKRMKESRLEDTQKHRVDFLQLMI-----DSQNSKETE----SHKALSDLELVAQSIIFIFAG 306

  Fly   315 FETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPL 379
            :||:||.:|..:||||..||:||:|:|||::||.|  .....||.:.||.|||.|::||||..|:
Human   307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN--KAPPTYDTVLQMEYLDMVVNETLRLFPI 369

  Fly   380 LPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAY 444
            ...|.|...||.:|  :.:.:.||::.:||.:.:|.||:.:.|||||.|.||..:...|..|..|
Human   370 AMRLERVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432

  Fly   445 LPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVE 507
            .|||.|||||||:||..:..|:.|:.:|:.|.|.....|.:||..|... ||.....:.||||
Human   433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPVVLKVE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	169/487 (35%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	169/487 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850