DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	516	Identity:	170/516 - (32%)
Similarity:	273/516 - (52%)	Gaps:	45/516 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKG 65
            ||...:||.:.|   |..|  ....:|:.|:|...|||.:|.:....|.:...||  :.:||:
Mouse    13 MLLATSLVLLYL---YGTH--SHGIFKKLGIPGPKPLPFLGTILAYQKGFWECDI--QCHKKY-- 68

  Fly    66 QGPIAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDP---LTGHLFALEGEEWR 126
             |.:.|:|...:....|||.|.||.|::|: :|.|.:|..|     .|   |...:...|.|||:
Mouse    69 -GKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF-----GPVGILKKAISISENEEWK 127

  Fly   127 AMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCA 191
            .:|..|:|.||||::|:|..:|    .:..|.:.:.:::...|.....:||:...::.|||.:.:
Mouse   128 RIRALLSPTFTSGRLKEMFPII----NQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATS 188

  Fly   192 FGLECNSLQDPSAEFRQKGR-----EIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFM 251
            ||:..:||.:|...|.:|.:     :||.....|..:..|:   ..:...|.:.:.|.|:..||.
Mouse   189 FGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFL---TPVFDALNVSLFPRDVISFFT 250

  Fly   252 STVKNTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGF 315
            ::|:...:.|:|...| |.||::.||..:....:.:.|        .|:..::.||:.:|..||:
Mouse   251 TSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHK--------ALSDVEIVAQSVIFIFAGY 307

  Fly   316 ETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLL 380
            ||:||.:|..||.||:.||:|::|::||::.|.|  .....||.|.||.|||.|::||||.:|:.
Mouse   308 ETTSSALSFALYLLAIHPDVQKKLQDEIDAALPN--KAPATYDTLLQMEYLDMVVNETLRLYPIA 370

  Fly   381 PHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYL 445
            ..|.|....|.:|  :.:.:.||.:.:||...:|.||:.:||||:|.|.||..:...:.:|..||
Mouse   371 GRLERVCKTDVEI--NGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYL 433

  Fly   446 PFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKV 506
            |||.|||||||:||..|..|:.||.:|:.|.......|::||..||:. ||...:.:.|||
Mouse   434 PFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQG-LLQPENPLLLKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	159/483 (33%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	158/481 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840