Protein Alignment Cyp6a14 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_610389.3
• Gene: Cyp6a14 / 35835
• FlyBaseID: FBgn0033302
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 133/504 - (26%)
• Similarity: 225/504 - (44%)
• Gaps: 81/504 - (16%)

  Fly    31 VPHETPL----PIVGNMRGIVKKYHFRDINQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQV 91
            :|:|..|    .::.||..::..:               .||:..:       .::...|:||.:
Human    76 LPNEAGLQDEKKVLDNMHHVLLVW---------------MGPVLPL-------LVLVHPDYIKPL 118

  Fly    92 MIKDFSYFQDRGAFTNPRDDPLTGH--------LFALEGEEWRAMRHKLTPVFTSGKIKQMSKVI 148
            :        ...|...|:||...|.        |...:|::|...|..|||.|....:|...|:.
Human   119 L--------GASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIF 175

  Fly   149 VDVGLRLGDAMDKAVKEAKVEEGNVEIKDL---CARFTTDVIGSCAFGLECNSLQDPSAEFRQKG 210
                .:..|.|.  .|...:.||:....|:   .:..|.|.:..|.|....| .|:..:::....
Human   176 ----NQSADIMH--AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSN-CQEKMSDYISAI 233

  Fly   211 REI--FTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVKN----------TVDYRLK 263
            .|:  .:.||...|.....|...|.|...|.:...|.:..|....::.          ....:.|
Human   234 IELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAK 298

  Fly   264 NGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYE 328
            .| |..|||:.::..|.||        |.:||.    |.:.|:|..|...|.:|:||.:|..|:.
Human   299 QG-KTLDFIDVLLLARDED--------GKELSD----EDIRAEADTFMFEGHDTTSSGISWMLFN 350

  Fly   329 LALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQI 393
            ||..|:.|::.||||:.|:...:..||.:|.|.|:.:....:.|:||::|.:..:.|:.|:|.::
Human   351 LAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKL 415

  Fly   394 PNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLR 458
            |:..|: .|||:.|:.::..||:|.::|:.:.::|.||||:..:.|.|:||:||..|||||||..
Human   416 PDGRII-PKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQS 479

  Fly   459 FGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVE 507
            |...:.::.:...|.||:.||.....|.   .|...:|.|.:|::||||
Human   480 FAMAELRVVVALTLLRFRLSVDRTRKVR---RKPELILRTENGLWLKVE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_610389.3	CYP6-like	65..503	CDD:410679	124/460 (27%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	127/494 (26%)