DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and CASR

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001171536.2	Gene:	CASR / 846	HGNCID:	1514	Length:	1088	Species:	Homo sapiens

Alignment Length:	1084	Identity:	302/1084 - (27%)
Similarity:	499/1084 - (46%)	Gaps:	143/1084 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 EGDVILGGLMMVH-----------SREDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNIT 444
            :||:|||||..:|           ||.:|:.|.....: |.:.|:||:|.|:.||.. .||||:|
Human    29 KGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFR-GFRWLQAMIFAIEEINSSPALLPNLT 92

  Fly   445 LGAHILDDCDKDSYGLEMAVDFI-KGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANL 508
            ||..|.|.|:..|..||..:.|: :..|.:::..|: ||.::.......||||..|..|..||||
Human    93 LGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEF-CNCSEHIPSTIAVVGATGSGVSTAVANL 156

  Fly   509 LRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIK 573
            |.||.||||||.|:|..||||.:|:.|.||||:|.:|..||.:|::...|::|..|..:.:||..
Human   157 LGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRP 221

  Fly   574 AFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRA 638
            ..|:..|.....:|||...| |:......|:|.:   |.:::....|:..::|.|..::..:::.
Human   222 GIEKFREEAEERDICIDFSE-LISQYSDEEEIQH---VVEVIQNSTAKVIVVFSSGPDLEPLIKE 282

  Fly   639 VRRANATGSFSWIGSDGWSARNLVS-DDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            :.|.|.||.. |:.|:.|::.:|:: ..|...|.||:....:|..:.||.|:...:....:..|.
Human   283 IVRRNITGKI-WLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNG 346

  Fly   703 WFVEFWEDHFQCRYPGSTSTP----------------YNN----YTKQCTTKERLSRQNTDFEDQ 747
            :..||||:.|.|........|                ::|    :...||..|.:|...|.:.|.
Human   347 FAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDY 411

  Fly   748 LQF-----VSDAVMAFAYALRDMHRDLCGGG---PSLCEAMKPTKGADLLKYLRKVEFEGLSGDE 804
            ...     |..||.:.|:||:|::..|.|.|   ...|..:|..:...:||:||.:.|....|::
Human   412 THLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQ 476

  Fly   805 FRFDGNGDGPARYNIIHFKQS-QAGQYHWVKVGEYT----EGE-LRLNMTEVKFKRLSPKP---- 859
            ..||..||....|:||::..| :.|...:.:||.|.    :|| |.:|..::.:...|.:|
Human   477 VTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTFV 541

  Fly   860 ------PESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPD---A 914
                  |.|.||..||.|..|..:||| :||:.|..|...:.....|.:.|..|     ||   :
Human   542 LSVLQVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKC-----PDDFWS 601

  Fly   915 HKQYCRPI-PEI-YLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLA 977
            ::.:...| .|| :|.....:.|....|:..||.:|.||:|||::..:||||:|:.|||||:||.
Human   602 NENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLF 666

  Fly   978 GIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISP 1042
            .:..|:..:...:.:|.:..|.:::...|..|.:..:.:|.||||:..:|:|...::....:...
Human   667 SLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGL 731

  Fly  1043 KSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDSYIDASYMIAF--SYPIFLIV 1105
            ..|.::......:||:|..:|:..||..:..:... ||.::....:..:...:.|  .|...|..
Human   732 NLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQEL-EDEIIFITCHEGSLMALGFLIGYTCLLAA 795

  Fly  1106 ICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASV- 1169
            ||..:|..:||:||.|||:|.|.|:|....::|::|:|.|..|....   ::::.|...|:||.
Human   796 ICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF---VSAVEVIAILAASFG 857

  Fly  1170 TIACLFSPKLYIILIRPERNV----------------------RQSMMPPRYGNMHRTAGTGPSS 1212
            .:||:|..|:||||.:|.||.                      |.::...|..::..:.|:.|||
Human   858 LLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSS 922

  Fly  1213 MMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQY 1277
            .:::...:.....|.|: ||...|.......:.::...:..|..|           .|.|...|.
Human   923 SISSKSNSEDPFPQPER-QKQQQPLALTQQEQQQQPLTLPQQQRS-----------QQQPRCKQK 975

  Fly  1278 VPNNATTAT-TTPTDKGSGNGNSNSNSNTNGSSNSNSNSN-------------GDGDV-ATEQVV 1327
            |...:.|.| :...|:...|..::.||....|..:..:|:             |:.|: .|.|..
Human   976 VIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQET 1040

  Fly  1328 ANNNKINQRQHGQPAV--------AFAITSTNNH-ISGPAATIT 1362
            .....:...|  :|.|        |..::|:.:. |||..:|:|
Human  1041 GLQGPVGGDQ--RPEVEDPEELSPALVVSSSQSFVISGGGSTVT 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	156/501 (31%)
		ANF_receptor	422..820	CDD:279440	133/428 (31%)
		NCD3G	861..910	CDD:284890	17/49 (35%)
		7tm_3	945..1181	CDD:278433	70/238 (29%)
CASR	NP_001171536.2	Ligand-binding 1 (LB1). /evidence=ECO:0000303\|PubMed:17360426	22..188		67/160 (42%)
		PBP1_CaSR	33..530	CDD:380587	155/503 (31%)
		Anion binding. /evidence=ECO:0000269\|PubMed:27434672, ECO:0007744\|PDB:5K5S, ECO:0007744\|PDB:5K5T	66..70		1/4 (25%)
		Ligand-binding 2 (LB2). /evidence=ECO:0000303\|PubMed:17360426	189..324		35/139 (25%)
		Anion binding. /evidence=ECO:0000269\|PubMed:27434672, ECO:0007744\|PDB:5K5S, ECO:0007744\|PDB:5K5T	415..417		0/1 (0%)
		NCD3G	548..601	CDD:369426	20/57 (35%)
		Cysteine-rich (CR). /evidence=ECO:0000303\|PubMed:17360426	552..622		22/74 (30%)
		7tmC_CaSR	621..872	CDD:320409	76/254 (30%)
		TM helix 1	622..646	CDD:320409	10/23 (43%)
		TM helix 2	658..679	CDD:320409	8/20 (40%)
		TM helix 3	688..710	CDD:320409	4/21 (19%)
		TM helix 4	736..752	CDD:320409	3/15 (20%)
		TM helix 5	779..802	CDD:320409	5/22 (23%)
		TM helix 6	811..836	CDD:320409	10/24 (42%)
		TM helix 7	841..866	CDD:320409	7/27 (26%)
		Interaction with RNF19A. /evidence=ECO:0000269\|PubMed:16513638	890..910		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	902..973		14/82 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	996..1016		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1040..1065		4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6384
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760