DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and olfcn1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_009291983.1	Gene:	olfcn1 / 793310	ZFINID:	ZDB-GENE-061117-2	Length:	855	Species:	Danio rerio

Alignment Length:	860	Identity:	242/860 - (28%)
Similarity:	413/860 - (48%)	Gaps:	104/860 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GDVILGGLMMVHSREDSITCGPIMPQGGIQA-----------------LEAMLFTIDRINR-EQL 439
            ||:::||:..:.:::::|.       |..:.                 :::|:|.:|.||: |:|
Zfish    36 GDIMIGGIFPIFNKQENII-------GSFERNMQRIKCTGFDLRAFRWIQSMMFAVDEINKNEEL 93

  Fly   440 LPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQ 504
            ||:|:||..|:|.|...:..|......    :|...:.|:   .:|....::.:|..:.|..|:.
Zfish    94 LPHISLGYKIMDSCASPTNVLRAVFSL----VSEQKEQEF---TSQCHLPLTALVAESGSSQSLA 151

  Fly   505 VANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESN 569
            ||.:|..||:|.||||||...||:::::..|.||||||.||.||:..:||:.||:::..:..:::
Zfish   152 VAGMLGPFRVPMVSYFSTCACLSDRKKYPSFFRTIPSDFYQAKALASLVKQFGWTWIGALQSDND 216

  Fly   570 Y---GIKAF-EELEELLARHNICIAIKEKLVK---DSGVAEDIAYDNIVQKLLTKPRARGAIIFG 627
            |   ||.|| :|:|::    .:|||....:::   .|.:.|       |.:::.:...:..:.|.
Zfish   217 YGRNGISAFTKEVEKM----GVCIAFVGTILRTYPQSKITE-------VVEMIKESTVKVILAFV 270

  Fly   628 SDQEVRQVMRAVRRANATGSFSWIGSDGW--SARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYF 690
            .:.::..:|:.|...|.|| ..||.|:.|  :||....:.:: ...||:....:...:.....|.
Zfish   271 PEGDLYPLMKEVVNRNITG-IQWIASEAWVTAARPSTPEMFK-SFGGTVGFVVRKMAMLKLRPYL 333

  Fly   691 LSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYT---KQCTTKERLSRQNTD-FEDQLQF- 750
            .:::..:..::.:..:|||....|: |.....|..|.|   :.||.:|:|:  .|| |.|..|.
Zfish   334 ENISPYSPTQSAFVSDFWETVVGCK-PCLNCEPSANSTLNGQMCTGQEKLT--FTDKFFDVTQVR 395

  Fly   751 ----VSDAVMAFAYALRDMHRDL-CGGGPSLCE------AMKPTKGADLLKYLRKVEFEGLSGDE 804
                |..||.|.|:|:   |:.| |.|..:|.:      .:.|.:.:|   .|.:|.|....|:.
Zfish   396 VTYNVYQAVYAIAHAI---HKVLYCQGDNNLSKMCLNVSQITPKQVSD---QLERVNFIDEYGEN 454

  Fly   805 FRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYT---EGELRLNMTEVKF----KRLSPKPPES 862
            ..||.|||.||.|.:|:::.:| |:...|.||.::   :|..:|.:.|...    :.|.||   :
Zfish   455 VFFDENGDPPASYELINWQLNQ-GEVQHVTVGYFSKSPDGTYKLTIKEDNVHWSTENLIPK---A 515

  Fly   863 VCSLPCLVGQAKKYVEGES-CCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIY 926
            |||..|..|..|..::|.. ||:.|..|....|.:......|.||......:..:..|......:
Zfish   516 VCSDTCPKGTRKAQIKGRPVCCFDCIPCADGSISNTTGAADCTLCPKEYWSNERRDKCLVKTIEF 580

  Fly   927 LRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVL 991
            |.......|...|.|..|..:|:..|.||:.:.:||||:|:..|||.:||:.:|.|:......:.
Zfish   581 LSYTETMGIILTALSLFGASLTVATMIVFIHYRETPIVKANNSELSSLLLSSLFFCFLCPLTFIG 645

  Fly   992 KPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQ 1056
            :||:..|.::....|..|.:..:.:|.||..:...|:|.....|......|..|..|.....::|
Zfish   646 EPTHWSCMLRHTAFGLTFALCISCVLGKTIVVVTAFRATLPGNKLSGKFGPVQQRAIVFLCTAIQ 710

  Fly  1057 ILINGVWMVIAPSHAMHHYP---TREDN---LLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTR 1115
            |:|..:|::|.|.     :|   .|.|:   :|.|::..||.:..|..|...|..||.:.|.|.|
Zfish   711 IVICALWLLIKPP-----FPDKALRYDHKKIILECNTGSDAGFYAALGYVGLLSTICLILAFLGR 770

  Fly  1116 KIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLY 1180
            |:|:.|||:|.|.|:|...|.:|:.|:|.|..:.....:.:...:  |..||...:.|:|:||.:
Zfish   771 KLPDNFNEAKFISFSMLIFCAVWVTFIPAYISSPGKYTVAVEIFA--ILSSAFGLLLCIFAPKCF 833

  Fly  1181 IILIRPERNVRQSMM 1195
            ||||:||||.|:.:|
Zfish   834 IILIKPERNTRKHVM 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	135/499 (27%)
		ANF_receptor	422..820	CDD:279440	121/440 (28%)
		NCD3G	861..910	CDD:284890	15/49 (31%)
		7tm_3	945..1181	CDD:278433	72/241 (30%)
olfcn1	XP_009291983.1	Periplasmic_Binding_Protein_Type_1	34..506	CDD:299141	136/506 (27%)
		ANF_receptor	75..473	CDD:279440	122/426 (29%)
		NCD3G	516..565	CDD:284890	15/48 (31%)
		7tm_3	601..834	CDD:278433	72/239 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910