DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and olfcs2

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001094425.1	Gene:	olfcs2 / 570726	ZFINID:	ZDB-GENE-060503-238	Length:	856	Species:	Danio rerio

Alignment Length:	852	Identity:	239/852 - (28%)
Similarity:	388/852 - (45%)	Gaps:	81/852 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 EGDVILGGLMMVHSR-----------EDSITCGPIMPQG----GIQALEAMLFTIDRINREQ-LL 440
            |||||:|||..|::.           ::...|     ||    ..:.|:.||||::.|||:. ||
Zfish    36 EGDVIIGGLFPVYNEAPVPNHAFTQIQNRSRC-----QGVDLRSYRWLKTMLFTVEEINRDPFLL 95

  Fly   441 PNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQV 505
            |||.||..:.|.|..:|..|..|:..:.|....:.|.|  |   .|...:..:||.|.|..||.|
Zfish    96 PNIILGYLVADTCLAESTTLSAALAIMTGQEETVSDTE--C---IVAPRVPVIVGDARSSASIGV 155

  Fly   506 ANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY 570
            |:.|.:|.||.||||::...|.:..||..|.||:|||.:|.|||..::..:.|::|.::..:..|
Zfish   156 ADTLGVFDIPMVSYFASCACLGDNHRFHTFLRTVPSDAFQAKAMARLLHLLDWTWVGVVAGDDEY 220

  Fly   571 GIKAFEELEELLARHNICIAIKEKLVKDSG---VAEDIAYDNIVQKLLTKPRARGAIIFGSDQEV 632
            |....:.|.:.|....:|:...|.:.|...   :...:       :.:....|...:.|....::
Zfish   221 GKSGVQLLLKELEHVGVCVDYLEFIPKSHSQRRIRRTV-------ETIQSSTAHVVVTFAIAPDI 278

  Fly   633 RQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYE-PEVEGTLSVQPQANPVRGFEEYFLSLTVE 696
            ..:.:.|...|.|.. .||.::.||......|... |.:.|||........:.|...|...|...
Zfish   279 EVLFKEVVVQNVTNR-QWIATEAWSTSVQFLDPASIPLLAGTLGFALHRADIEGLGAYLSQLNPA 342

  Fly   697 NNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQF-----VSDAVM 756
            .....|:..:.||:.|.|.........:..  .:||..|.:......:.|..|.     |..||.
Zfish   343 KQSNEPFVKDVWEEIFGCSLAQDWQPSFKR--PKCTGSENVEIHGGIYTDVSQLRVTYNVYKAVY 405

  Fly   757 AFAYALRDMHRDLCGGGP---SLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYN 818
            |.|||:.:|.....|.||   ..|..:...|...||.||..|.|....|:...|:.||:..|.|:
Zfish   406 AIAYAIHNMIACQPGRGPFENGQCPDVNQIKPRQLLHYLNAVNFTTPVGELVYFEDNGEPSASYD 470

  Fly   819 IIHFKQSQAGQYHWVKVGEYTEG-----ELRLNMTEVKF-KRLSPKPPESVCSLPCLVGQAKKYV 877
            |:::...::|..::|:||::...     ||.:|:.:|.: ...|.:.|.||||:.||.|..|...
Zfish   471 IMNWHVDESGAVNFVQVGQFDAANGPGQELNINIKKVVWGGGWSDQVPVSVCSVSCLPGTRKSVQ 535

  Fly   878 EGES-CCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEI--YLRPESAWAIGAMA 939
            :|:: ||:.|..|...:|.:..|.|.|..|......:..:..|  :|:|  :|..:....|....
Zfish   536 KGKAICCFDCLPCAAGEISNLTDSTKCIRCPEKFWSNVERTKC--VPKIVEFLSLQDTMGIVLTV 598

  Fly   940 FSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFG 1004
            .|.||..:|..|:..|..|.|||:|||:..|||::||..:.:|:......:.:|....|.::...
Zfish   599 LSVTGATLTTTVLATFFHHRDTPLVRANNSELSFMLLVSLTLCFLCALVFIGRPATWNCMLRHTL 663

  Fly  1005 VGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQ---LVICACLVSVQILINGVWMVI 1066
            .|..|.:..|.:|:||..:...|:|....:....:..|..|   :::|   ..||::|..:|:::
Zfish   664 FGVSFVICIACILSKTVVVLVAFQATLPGSNLMQYFGPIQQRAGILVC---TMVQVVICLLWLLL 725

  Fly  1067 APSHAMHHYPTREDN-------LLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNES 1124
            ||.     .||....       :|.|.......:.:...|...|.|:|.:.|...||:|::|||:
Zfish   726 APP-----LPTERAGGEFGARVILQCTVGSVVGFALVLGYIGLLAVVCFLLAFFARKLPDSFNEA 785

  Fly  1125 KHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASV-TIACLFSPKLYIILIRPER 1188
            |.|.|:|...|.:|:.|||.|..:.....:.:...::   |::|. .:.|:|:||.||||::||:
Zfish   786 KFITFSMLIFCTVWIVFVPAYVSSPGKYTVAVEIFAI---LASSYGLLLCIFTPKCYIILLKPEK 847

  Fly  1189 NVRQSMM 1195
            |.:::||
Zfish   848 NTKKNMM 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	133/486 (27%)
		ANF_receptor	422..820	CDD:279440	115/410 (28%)
		NCD3G	861..910	CDD:284890	18/49 (37%)
		7tm_3	945..1181	CDD:278433	66/246 (27%)
olfcs2	NP_001094425.1	Periplasmic_Binding_Protein_Type_1	35..509	CDD:299141	136/492 (28%)
		ANF_receptor	76..475	CDD:279440	116/413 (28%)
		NCD3G	519..570	CDD:284890	18/50 (36%)
		7tm_3	614..840	CDD:278433	64/236 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910