DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and grm8b

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001274468.1	Gene:	grm8b / 569768	ZFINID:	ZDB-GENE-110421-3	Length:	907	Species:	Danio rerio

Alignment Length:	933	Identity:	385/933 - (41%)
Similarity:	551/933 - (59%)	Gaps:	78/933 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 LRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQA 423
            |..:..|:|.:.|.|....|:....::    ::||:|||||..||:| |....||.:..:.||..
Zfish    14 LTGVTRSISQRTDPLTPPAPEYAHSIR----LDGDIILGGLFPVHARGERGAPCGELKKEKGIHR 74

  Fly   424 LEAMLFTIDRINRE-QLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNK---- 483
            ||||||.||.||:: .||||:||||.|||.|.:|:|.||.::.|::..|.. |..:..|..
Zfish    75 LEAMLFAIDLINKDPDLLPNVTLGARILDTCSRDTYALEQSLTFVQALIER-DSTDVRCASGEQP 138

  Fly   484 --TQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQV 546
              .:..|:| ||:|||:|..||.|||:||||:|||:||.||:||||:..|:::|||.:|.|.||.
Zfish   139 IFAKPDKII-GVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQA 202

  Fly   547 KAMVEIVKRMGWSYVSIIYEESNY---GIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYD 608
            :||::||..|||:|||.:..|.||   |::||.::..  ....:|||...|:.::....|   :|
Zfish   203 QAMLDIVTAMGWNYVSTLASEGNYGESGVEAFVQISR--ETGGVCIAQSLKIPREPRPGE---FD 262

  Fly   609 NIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGT 673
            .|:.:||..|.||..::|.::.::|:|:.|.:|.|.||.|.|:|||.|.::.......|...||.
Zfish   263 KIILRLLETPSARAIVMFANEDDIRRVLDAAKRNNQTGHFLWVGSDSWGSKISPVVQQESVAEGA 327

  Fly   674 LSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRY------PGSTSTPYNNYTKQCT 732
            :::.|:...:..|:.||.|.::.||:||.||.||||::|.|:.      |||        .::||
Zfish   328 ITILPKRASIEAFDRYFKSRSLSNNRRNVWFAEFWEENFGCKLGMHGKRPGS--------PRKCT 384

  Fly   733 TKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVE 796
            ..|::.|.:| :.|.::|||.|||.|.|:||..||||||.|.|.||..|....|.:||.|:|.|.
Zfish   385 GLEKVGRDSTYEQEGKVQFVMDAVYAMAHALHRMHRDLCSGYPGLCPRMSNIDGKELLGYIRNVS 449

  Fly   797 FEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPE 861
            |.|.:.....|:.|||.|.||:|..::.:.....:.: :|.:|: :|.||:..:::.......|.
Zfish   450 FNGSAKTLVVFNENGDAPGRYDIYQYQITNKSTEYRI-IGHWTD-QLHLNINAMQWASGDDVMPT 512

  Fly   862 SVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIY 926
            |||||||.:|:.||.|:|..|||||..|..|  .:...|..|::|.....||.::..|:|||.|.
Zfish   513 SVCSLPCQMGERKKIVKGVPCCWHCERCEGY--HYQASEFTCQICPYELRPDQNRTGCQPIPIIK 575

  Fly   927 LRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVL 991
            |...|.||:..:..:..|||.|.||:..|||:||||||||||||:||:||.|||:||.:||.::.
Zfish   576 LEWHSPWAVVPVFIAILGILATTFVVVTFVRYNDTPIVRASGREMSYVLLTGIFLCYVITFPMIG 640

  Fly   992 KPTNIVCAIQR--FGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVS 1054
            .|...||:.:|  .|:|.||:  |||||||||||.|||:.||.|...|.||||.|||||...|:|
Zfish   641 APGVAVCSFRRIFLGLGMCFS--YAALLTKTNRIHRIFEQGKCSVAAPRFISPASQLVITFSLIS 703

  Fly  1055 VQILINGVWMVIAPSHAMHHY-------PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAV 1112
            ||::...||.|:.|.|.:..|       |.....:|.|| ..|.|.:.:..|.|.|:|.|||||:
Zfish   704 VQLMGVFVWFVVDPPHTVVDYGEQRTQDPKNARGVLKCD-ISDLSLICSLGYSILLMVTCTVYAI 767

  Fly  1113 LTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTA---NHVPLRITSMSVTISLSASVTIACL 1174
            .||.:||.|||:|.|||||||||:|||||:|::||||   ..:.::..:::|::||||||::..|
Zfish   768 KTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSEERMYIQTATLTVSLSLSASVSLGML 832

  Fly  1175 FSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNT 1239
            :.||:|||::.||:||     |.|..:.             .|:|||||...:   ...:.....
Zfish   833 YMPKVYIIILHPEQNV-----PKRKRSF-------------KAIVTAATMTNK---LSQLASERP 876

  Fly  1240 ENSLKTKKLCEMATQTISSIITS 1262
            ...:|| :|||....:..|..|:
Zfish   877 NGEVKT-ELCESVDNSAPSTKTT 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	193/471 (41%)
		ANF_receptor	422..820	CDD:279440	173/414 (42%)
		NCD3G	861..910	CDD:284890	22/48 (46%)
		7tm_3	945..1181	CDD:278433	128/247 (52%)
grm8b	NP_001274468.1	Periplasmic_Binding_Protein_Type_1	43..503	CDD:299141	194/476 (41%)
		ANF_receptor	73..477	CDD:279440	174/418 (42%)
		NCD3G	512..558	CDD:284890	22/47 (47%)
		7tm_3	594..839	CDD:278433	128/247 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9765
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H654
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.710