DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and grm6a

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_021333966.1	Gene:	grm6a / 568484	ZFINID:	ZDB-GENE-060208-1	Length:	908	Species:	Danio rerio

Alignment Length:	882	Identity:	376/882 - (42%)
Similarity:	544/882 - (61%)	Gaps:	63/882 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 VEGDVILGGLMMVHSREDS-ITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDC 453
            :.||:.||||..||||..: :.||.|..:.||..|||||:.:|:||.: :|||||||||.|||.|
Zfish    58 IPGDITLGGLFPVHSRGPAGVPCGEIKKEKGIHRLEAMLYALDQINSDPELLPNITLGARILDTC 122

  Fly   454 DKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQ---VRKV--ISGVVGAASSVTSIQVANLLRLFR 513
            .:|:|.||.::.|::..|.. |.::..|:..:   :||.  :.||:||:.|..||.|||:||||.
Zfish   123 SRDTYALEQSLTFVQALIQK-DTSDIRCSNGEQPIIRKPERVVGVIGASGSSVSIMVANVLRLFE 186

  Fly   514 IPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GIKAF 575
            |||:||.||:||||:..|:::|||.:|.|.||.:|||:|||.|||:|||.:..|.||   |:.||
Zfish   187 IPQISYASTAPELSDNNRYDFFSRVVPPDSYQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAF 251

  Fly   576 EELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVR 640
            .::..  ....:|||...|:.::....|   :|.|:::|:..|.|||.|||..:.:::||:.|.|
Zfish   252 VQISR--ETGGLCIAQSMKIPREPKPGE---FDKIIKRLMETPNARGVIIFAHEDDIKQVLEAAR 311

  Fly   641 RANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFV 705
            |:|.||.|.::|||.|.|::....|.|...||.:::.|:...:.||::||.:.::|||:||.||.
Zfish   312 RSNLTGHFKFVGSDSWGAKSSPILDQEDVAEGAVTILPKRASIDGFDQYFTTRSLENNRRNIWFA 376

  Fly   706 EFWEDHFQCRY--PGSTSTPYNNYTKQCTTKERLSR-QNTDFEDQLQFVSDAVMAFAYALRDMHR 767
            |||||.|:|:.  ||....|..   |:||.:||:|| .:.:.|.::|||.|||.|.|:||.:||:
Zfish   377 EFWEDDFRCKLTRPGIKIDPEK---KKCTGEERISRDSHYEQEGKVQFVIDAVYAMAHALHNMHQ 438

  Fly   768 DLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHW 832
            :||.|...:|:.|.|.:|..||.|:|.|.|.|.:|....|:.|||.|.||:|..::.:......:
Zfish   439 ELCPGATGVCDKMDPVEGRSLLNYIRAVNFNGSAGTAVLFNENGDAPGRYDIFQYQMTNTSSPGY 503

  Fly   833 VKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHP 897
            ..:|::| ..||||:.|:::...|.:.|:||||.||..|:.||.|:|..|||||..|..||.:
Zfish   504 RVIGQWT-NNLRLNVEEMQWTGGSRQIPDSVCSFPCRSGERKKMVKGVPCCWHCELCDGYQFQ-- 565

  Fly   898 DDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTP 962
            .||.:|::|.....|..::..|||.|.|.|...|.||:..:..:..|||.|||::..|:|.||||
Zfish   566 ADEFNCEMCPFDMRPTLNRTACRPTPIIKLEWHSPWAVIPLFLAILGILATLFIIITFIRFNDTP 630

  Fly   963 IVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIF 1027
            ||||:||||||:||.|||:.|.:||.::.:|..:|||.:|..:|...::.|:|:|||||||.|||
Zfish   631 IVRAAGRELSYVLLTGIFLIYLITFLMIAEPGTVVCAFRRLLLGLGMSITYSAMLTKTNRIYRIF 695

  Fly  1028 KAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY-------PTREDNLLVC 1085
            :.||:|...|.||||.|||:|...|:|||::...||..:.|.|....|       |.....:|.|
Zfish   696 EQGKKSVTPPKFISPTSQLMITFVLISVQVVGVFVWFGVMPPHTTVDYEELRPPNPELARGILKC 760

  Fly  1086 DSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTAN 1150
            | ..|.|.:...||.|.|:|.||||||.:|.:||.|||:|.|||||||||:|||||||::||||.
Zfish   761 D-MSDLSLICCLSYSIVLMVTCTVYAVKSRGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQ 824

  Fly  1151 HVP---LRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSS 1212
            ...   ::.|:::|::||||||::..|:.||:|:|:..||:||::                  ..
Zfish   825 STEKMFIQTTTLTVSMSLSASVSLGMLYIPKVYVIIFHPEQNVQK------------------RK 871

  Fly  1213 MMAAAVVTAATCA---------QEEKIQKHITPTNTE 1240
            ....|||.|||.:         :::..:..|.|..|:
Zfish   872 RSFKAVVQAATMSSRLSQKSINEKQNGETKIEPDRTQ 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	200/466 (43%)
		ANF_receptor	422..820	CDD:279440	179/409 (44%)
		NCD3G	861..910	CDD:284890	23/48 (48%)
		7tm_3	945..1181	CDD:278433	123/245 (50%)
grm6a	XP_021333966.1	PBP1_mGluR_groupIII	60..522	CDD:107371	202/471 (43%)
		NCD3G	532..580	CDD:311495	23/49 (47%)
		7tmC_mGluR_group3	600..870	CDD:320413	132/288 (46%)
		TM helix 1	600..625	CDD:320413	9/24 (38%)
		TM helix 2	637..658	CDD:320413	13/20 (65%)
		TM helix 3	667..691	CDD:320413	10/23 (43%)
		TM helix 4	713..733	CDD:320413	9/19 (47%)
		TM helix 5	763..789	CDD:320413	13/25 (52%)
		TM helix 6	797..820	CDD:320413	18/22 (82%)
		TM helix 7	830..855	CDD:320413	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810