DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm5a

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001315639.1	Gene:	grm5a / 568406	ZFINID:	ZDB-GENE-090821-9	Length:	1173	Species:	Danio rerio

Alignment Length:	1098	Identity:	388/1098 - (35%)
Similarity:	567/1098 - (51%)	Gaps:	149/1098 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 AIVEGDVILGGLMMVHSR--EDSI---TCGPIMPQGGIQALEAMLFTIDRINREQL-LPNITLGA 447
            |.:.||:|:|.|..||.:  .|.:   .||.:..|.|||.:|||:.|:||||.:.| |||||||.
Zfish    34 AHIPGDIIIGALFSVHHQPPADKVHERKCGAVREQYGIQRVEAMMHTLDRINADPLILPNITLGC 98

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAE--YHCN------KTQVRKVISGVVGAASSVTSIQ 504
            .|.|.|...:..||.:::||:.::.:.::.|  ..|:      ..:.:|.|.|::|..||..:||
Zfish    99 EIRDSCWHSAVALEQSIEFIRDTLVSAEEEEGMAKCSTEGGGTPMKGKKPIVGLIGPGSSSVAIQ 163

  Fly   505 VANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESN 569
            |.|||:||.|||::|.:||.:||:|..::||.|.:|||..|.:|||:||||..|:|||.|:.|.|
Zfish   164 VQNLLQLFNIPQIAYSATSMDLSDKSLYKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAIHTEGN 228

  Fly   570 YGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVR 633
            ||....|..:::.|:..||||..:|:..::|   :.::|.::.||.:. |:||....|.....||
Zfish   229 YGESGMEAFKDMAAKEGICIAHSDKIYSNAG---EQSFDRLLDKLRSHLPKARVVACFCEGMTVR 290

  Fly   634 QVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENN 698
            .::.|:||....|.|..:|||||:.|..|:|.::.|..|.::::.|:..|..|::|:|:|..:.|
Zfish   291 GILMAMRRRRLVGEFLLVGSDGWADRYDVTDGFQREAAGGITIKLQSAYVTWFDDYYLNLQPDTN 355

  Fly   699 QRNPWFVEFWEDHFQCRYPG--STSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYA 761
            .|||||.|||:..||||..|  ..|..||   |.||.||.|..|... :.::.||.:|:.:.|:.
Zfish   356 MRNPWFPEFWQHRFQCRLKGHPQESVKYN---KTCTKKESLRHQYAQ-DTKMGFVINAIYSMAFG 416

  Fly   762 LRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQ 826
            |..|.:.||.|...|||||:|..|..||::|.:..|.|:||:...||.|||.|.||.|::|||..
Zfish   417 LHAMQKSLCPGYAGLCEAMRPIDGGKLLEFLMRTNFSGVSGEVVLFDENGDSPGRYEIMNFKQMS 481

  Fly   827 AGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNCT 890
            ...|.::.||.:....|:::..|:...  |.....||||.||...|.|...:|| ||||.|..|.
Zfish   482 EEDYSYIHVGSWDNRGLKMDDEEIWAN--SSAIIRSVCSDPCEKAQIKVIRKGEVSCCWTCTPCK 544

  Fly   891 TYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVF 955
            ..:...  ||..|:.|:||:.|......|..||..||:......|.|:.|:..|:|.|:||..||
Zfish   545 ENEFVF--DEYTCRACELGSWPTDDLTGCERIPVQYLQWGDPEPIAAVVFACLGLLATIFVTLVF 607

  Fly   956 VRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKT 1020
            ||.:|||:|::|.|||.:|:||||.:.|..||.|:.||....|.:||.|:|....:.|:||:|||
Zfish   608 VRFHDTPVVKSSSRELCFIILAGICLGYLCTFCLIAKPHVAYCYLQRLGIGLSPAMSYSALVTKT 672

  Fly  1021 NRIARIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLL 1083
            ||||||....|:.  .|:|.|:|..:||||...|:.:|:.|.....::.|...::.||:..:..|
Zfish   673 NRIARILAGSKKKICTKKPRFMSACAQLVIAFILILIQLGIIVALFIMEPPQVIYDYPSIREVHL 737

  Fly  1084 VCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGT 1148
            :|:: .....:....|...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:|||
Zfish   738 ICNT-TTLGVVAPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG- 800

  Fly  1149 ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSM 1213
            :|:   :|.:|..::||||:..:.|:|.||:||:|.:||||||.:........||  .|.|.|:.
Zfish   801 SNY---KIITMCFSVSLSATTALCCMFVPKVYIMLAKPERNVRSAFTTSTVVRMH--VGDGKSAS 860

  Fly  1214 MAAAVVTAA--------------------TCAQEEK-----IQKHITPTNTENSLKTKKLCEMAT 1253
            .|:...:.|                    |.||.|:     :.|.|       |:..||. |.|.
Zfish   861 AASRSSSLANLFRRRPSGTDTVSSNGKTVTWAQNERSYRPNLWKRI-------SIHIKKK-EEAN 917

  Fly  1254 QTI--------------SSIITSLDINAYNQ---IPYADQYVPNNATTATTTPTDKGSGNGNSNS 1301
            ||.              :.:..|.|.:..||   :.|..: .|:...|....|:.|..
Zfish   918 QTAIIKPFSKGCDRPPDAGVKLSYDGSQKNQRYPVTYRPR-TPSPLPTICQRPSMKRC------- 974

  Fly  1302 NSNTNGSSNSNSNSNGDGDVATEQVVANNNKINQRQHGQPA------------VAFAITSTNNHI 1354
                         ...||:.|  ||||..:.:.:|...||:            ....||..|:.:
Zfish   975 -------------DVEDGERA--QVVAIPSYLTERLQHQPSSIMDQISCVVSQFTANITELNSMM 1024

  Fly  1355 ---SGPAATITTTA-----------------------ATGETTTEALVATITTPLATV 1386
               |.|...:.|||                       .|..|..:.:.|..|||.:.|
Zfish  1025 LPGSPPGTAVNTTATSANPPRPCSPSYRHHQQERPHPTTVTTYADVVAAANTTPRSAV 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	186/470 (40%)
		ANF_receptor	422..820	CDD:279440	165/409 (40%)
		NCD3G	861..910	CDD:284890	21/49 (43%)
		7tm_3	945..1181	CDD:278433	104/237 (44%)
grm5a	NP_001315639.1	PBP1_mGluR_groupI	31..502	CDD:107369	187/474 (39%)
		ANF_receptor	72..478	CDD:279440	166/412 (40%)
		NCD3G	514..563	CDD:284890	22/50 (44%)
		7tm_3	597..830	CDD:278433	104/237 (44%)
		GluR_Homer-bdg	1123..1173	CDD:287563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.670