Protein Alignment mtt and grm5a

DIOPT Version :10

• Sequence 1: NP_001260806.1
• Gene: mtt / 35832
• FlyBaseID: FBgn0050361
• Length: 1472
• Species: Drosophila melanogaster
• Sequence 2: XP_073770228.1
• Gene: grm5a / 568406
• ZFINID: ZDB-GENE-090821-9
• Length: 1253
• Species: Danio rerio
• Alignment Length: 1178
• Identity: 388/1178 - (32%)
• Similarity: 567/1178 - (48%)
• Gaps: 229/1178 - (19%)

  Fly   389 AIVEGDVILGGLMMVHSR--EDSI---TCGPIMPQGGIQALEAMLFTIDRINREQL-LPNITLGA 447
            |.:.||:|:|.|..||.:  .|.:   .||.:..|.|||.:|||:.|:||||.:.| |||||||.
Zfish    34 AHIPGDIIIGALFSVHHQPPADKVHERKCGAVREQYGIQRVEAMMHTLDRINADPLILPNITLGC 98

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAE--YHCN------KTQVRKVISGVVGAASSVTSIQ 504
            .|.|.|...:..||.:::||:.::.:.::.|  ..|:      ..:.:|.|.|::|..||..:||
Zfish    99 EIRDSCWHSAVALEQSIEFIRDTLVSAEEEEGMAKCSTEGGGTPMKGKKPIVGLIGPGSSSVAIQ 163

  Fly   505 VANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESN 569
            |.|||:||.|||::|.:||.:||:|..::||.|.:|||..|.:|||:||||..|:|||.|:.|.|
Zfish   164 VQNLLQLFNIPQIAYSATSMDLSDKSLYKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAIHTEGN 228

  Fly   570 YGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVR 633
            ||....|..:::.|:..||||..:|:..::|   :.::|.::.||.:. |:||....|.....||
Zfish   229 YGESGMEAFKDMAAKEGICIAHSDKIYSNAG---EQSFDRLLDKLRSHLPKARVVACFCEGMTVR 290

  Fly   634 QVMRAVRRANATGSFSWIG---------------------------------------------- 652
            .::.|:||....|.|..:|
Zfish   291 GILMAMRRRRLVGEFLLVGRDCGSDRATPSGRSVAVCLLNVHPRLLIIICFICVCERERDTKSRW 355

  Fly   653 ----------------------------------SDGWSARNLVSDDYEPEVEGTLSVQPQANPV 683
                                              ||||:.|..|:|.::.|..|.::::.|:..|
Zfish   356 IEAHLSVFHHHKCYHPHHRHHHHHCSEQSSTTEVSDGWADRYDVTDGFQREAAGGITIKLQSAYV 420

  Fly   684 RGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPG--STSTPYNNYTKQCTTKERLSRQNTDFED 746
            ..|::|:|:|..:.|.|||||.|||:..||||..|  ..|..||   |.||.||.|..|... :.
Zfish   421 TWFDDYYLNLQPDTNMRNPWFPEFWQHRFQCRLKGHPQESVKYN---KTCTKKESLRHQYAQ-DT 481

  Fly   747 QLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNG 811
            ::.||.:|:.:.|:.|..|.:.||.|...|||||:|..|..||::|.:..|.|:||:...||.||
Zfish   482 KMGFVINAIYSMAFGLHAMQKSLCPGYAGLCEAMRPIDGGKLLEFLMRTNFSGVSGEVVLFDENG 546

  Fly   812 DGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKY 876
            |.|.||.|::|||.....|.::.||.:....|:::..|:...  |.....||||.||...|.|..
Zfish   547 DSPGRYEIMNFKQMSEEDYSYIHVGSWDNRGLKMDDEEIWAN--SSAIIRSVCSDPCEKAQIKVI 609

  Fly   877 VEGE-SCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAF 940
            .:|| ||||.|..|...:...  ||..|:.|:||:.|......|..||..||:......|.|:.|
Zfish   610 RKGEVSCCWTCTPCKENEFVF--DEYTCRACELGSWPTDDLTGCERIPVQYLQWGDPEPIAAVVF 672

  Fly   941 SATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGV 1005
            :..|:|.|:||..||||.:|||:|::|.|||.:|:||||.:.|..||.|:.||....|.:||.|:
Zfish   673 ACLGLLATIFVTLVFVRFHDTPVVKSSSRELCFIILAGICLGYLCTFCLIAKPHVAYCYLQRLGI 737

  Fly  1006 GFCFTVVYAALLTKTNRIARIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAP 1068
            |....:.|:||:|||||||||....|:.  .|:|.|:|..:||||...|:.:|:.|.....::.|
Zfish   738 GLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILILIQLGIIVALFIMEP 802

  Fly  1069 SHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYT 1133
            ...::.||:..:..|:|:: .....:....|...||:.||.||..||.:|..|||:|:|.|||||
Zfish   803 PQVIYDYPSIREVHLICNT-TTLGVVAPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT 866

  Fly  1134 TCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPR 1198
            ||:|||||||:||| :|:   :|.:|..::||||:..:.|:|.||:||:|.:||||||.:.....
Zfish   867 TCIIWLAFVPIYFG-SNY---KIITMCFSVSLSATTALCCMFVPKVYIMLAKPERNVRSAFTTST 927

  Fly  1199 YGNMHRTAGTGPSSMMAAAVVTAA--------------------TCAQEEK-----IQKHITPTN 1238
            ...||  .|.|.|:..|:...:.|                    |.||.|:     :.|.|
Zfish   928 VVRMH--VGDGKSASAASRSSSLANLFRRRPSGTDTVSSNGKTVTWAQNERSYRPNLWKRI---- 986

  Fly  1239 TENSLKTKKLCEMATQTI--------------SSIITSLDINAYNQ---IPYADQYVPNNATTAT 1286
               |:..||. |.|.||.              :.:..|.|.:..||   :.|..: .|:...|..
Zfish   987 ---SIHIKKK-EEANQTAIIKPFSKGCDRPPDAGVKLSYDGSQKNQRYPVTYRPR-TPSPLPTIC 1046

  Fly  1287 TTPTDKGSGNGNSNSNSNTNGSSNSNSNSNGDGDVATEQVVANNNKINQRQHGQPA--------- 1342
            ..|:.|..                    ...||:.|  ||||..:.:.:|...||:
Zfish  1047 QRPSMKRC--------------------DVEDGERA--QVVAIPSYLTERLQHQPSSIMDQISCV 1089

  Fly  1343 ---VAFAITSTNNHI---SGPAATITTTA-----------------------ATGETTTEALVAT 1378
               ....||..|:.:   |.|...:.|||                       .|..|..:.:.|.
Zfish  1090 VSQFTANITELNSMMLPGSPPGTAVNTTATSANPPRPCSPSYRHHQQERPHPTTVTTYADVVAAA 1154

  Fly  1379 ITTPLATV 1386
            .|||.:.|
Zfish  1155 NTTPRSAV 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_type1	73..>157	CDD:471960
		PBP1_mGluR	393..848	CDD:380585	186/551 (34%)
		NCD3G	860..912	CDD:462210	22/52 (42%)
		7tmC_mGluRs	932..1184	CDD:320173	110/253 (43%)
		TM helix 1	932..957	CDD:320173	10/24 (42%)
		TM helix 2	969..990	CDD:320173	11/20 (55%)
		TM helix 3	999..1023	CDD:320173	11/23 (48%)
		TM helix 4	1045..1065	CDD:320173	7/19 (37%)
		TM helix 5	1089..1115	CDD:320173	7/25 (28%)
		TM helix 6	1123..1146	CDD:320173	17/22 (77%)
		TM helix 7	1153..1178	CDD:320173	8/24 (33%)
grm5a	XP_073770228.1	None