DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and grm6b

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001073489.1	Gene:	grm6b / 565450	ZFINID:	ZDB-GENE-021120-2	Length:	905	Species:	Danio rerio

Alignment Length:	854	Identity:	361/854 - (42%)
Similarity:	529/854 - (61%)	Gaps:	51/854 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 PDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVHSREDS-ITCGPIMPQGGIQALEAM 427
            |:|.:..:|    |||.   .:|    :|||:.||||..||||..: |.||.:..:.||..:|||
Zfish    40 PESQAASSD----TQPH---SIK----IEGDITLGGLFPVHSRGPAGIPCGEVKKEKGIHRMEAM 93

  Fly   428 LFTIDRINRE-QLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKV-- 489
            |:.:|:||.: .|||||||||.|||.|.:|:|.||.::.|::..|.. |:::..|:..:...:
Zfish    94 LYALDQINSDPDLLPNITLGARILDTCSRDTYALEQSLTFVQALIQK-DNSDVRCSNGEPPIIPK 157

  Fly   490 ---ISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVE 551
               :.||:||::|..||.|||:||||.|||:||.||:||||:..|:::|||.:|.|.:|.:|||:
Zfish   158 PERVVGVIGASASSVSIMVANVLRLFAIPQISYASTAPELSDNNRYDFFSRVVPPDSFQAQAMVD 222

  Fly   552 IVKRMGWSYVSIIYEESNY---GIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQK 613
            |||.|||:|||.:..|.||   |:.||.::..  ....:|||...|:.::....|   :|.|:::
Zfish   223 IVKAMGWNYVSTLASEGNYGESGVDAFIQISR--EAGGLCIAQAIKIPREPRPGE---FDKIIKR 282

  Fly   614 LLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQP 678
            |:....|||.|||.::.::::|:.|.:|||.||.|.::|||.|.|:.....:.|...||.:::.|
Zfish   283 LMETSNARGVIIFANEDDIKRVLEAAKRANLTGHFLFVGSDSWGAKISPILNQEDVAEGAVTILP 347

  Fly   679 QANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRY--PGSTSTPYNNYTKQCTTKERLSRQN 741
            :...:.||::||.:.::|||:||.||.|||||.|:|:.  ||...   :...::||.:||:.|.:
Zfish   348 KRASIEGFDQYFTTRSLENNRRNIWFAEFWEDDFKCKLTRPGIRG---DGGLRKCTGEERIGRDS 409

  Fly   742 -TDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEF 805
             .:.|.::|||.|||.|.|:||..||.|||.|...:|:.|.|..|..||.|:|.|.|.|.:|...
Zfish   410 GYEQEGKVQFVIDAVYAMAHALHSMHIDLCPGSMGVCDKMDPVDGRMLLTYIRAVNFNGSAGTGV 474

  Fly   806 RFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLV 870
            .|:.|||.|.||:|..::.|......:..:|::| ..|||:..::::.......|:||||.||..
Zfish   475 MFNENGDAPGRYDIFQYQLSNTTNPGYKLIGQWT-NHLRLSAEDMQWSGGEKLVPDSVCSFPCES 538

  Fly   871 GQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAI 935
            |:.|:.|:|..|||||..|..||...  ||.:|.:|.....|..::..|||.|.|.|...|.|||
Zfish   539 GERKRMVKGVPCCWHCELCDGYQFLL--DEFNCDMCPFDMRPTPNRTACRPTPIIKLEWSSPWAI 601

  Fly   936 GAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAI 1000
            ..:..:..|||.|..|:..|:|.|||||||||||||||:||.|||:.|.:||.::.:|..:|||.
Zfish   602 IPVFLAVLGILATTGVIATFIRFNDTPIVRASGRELSYVLLTGIFLIYLITFLMIAEPGTVVCAF 666

  Fly  1001 QR--FGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVW 1063
            :|  .|:|.|  :.|:|:|||||||.|||:.||:|...|.||||.|||:|...|:|||:|...:|
Zfish   667 RRLLLGLGMC--ISYSAMLTKTNRIYRIFEQGKKSVTPPKFISPTSQLIITFILISVQLLGIFIW 729

  Fly  1064 MVIAPSHAMHHY-------PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAF 1121
            ..:.|.|....:       |.....:|.|| ..|.|.:...||.:.|:|.|||||:.:|.:||.|
Zfish   730 FGVVPPHTNVDFDELRPPNPEFARGILKCD-MSDLSLIGCLSYSMGLMVTCTVYAIKSRGVPETF 793

  Fly  1122 NESKHIGFTMYTTCVIWLAFVPLYFGTANHVP---LRITSMSVTISLSASVTIACLFSPKLYIIL 1183
            ||:|.|||||||||:|||||||::|||:....   ::.|:::|::||||:|::..|:.||:|:|:
Zfish   794 NEAKPIGFTMYTTCIIWLAFVPIFFGTSQSTEKMFIQTTTLTVSMSLSATVSLGMLYIPKVYVII 858

  Fly  1184 IRPERNVRQ 1192
            ..||:||::
Zfish   859 FHPEQNVQK 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	192/466 (41%)
		ANF_receptor	422..820	CDD:279440	170/409 (42%)
		NCD3G	861..910	CDD:284890	22/48 (46%)
		7tm_3	945..1181	CDD:278433	120/247 (49%)
grm6b	NP_001073489.1	PBP1_mGluR_groupIII	58..520	CDD:107371	192/471 (41%)
		ANF_receptor	88..492	CDD:279440	171/412 (42%)
		NCD3G	530..576	CDD:284890	22/47 (47%)
		7tm_3	611..856	CDD:278433	120/247 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810