DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and grm3

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001121815.1	Gene:	grm3 / 565256	ZFINID:	ZDB-GENE-061009-13	Length:	884	Species:	Danio rerio

Alignment Length:	896	Identity:	369/896 - (41%)
Similarity:	536/896 - (59%)	Gaps:	57/896 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 KREAIVEGDVILGGLMMVHSREDSI-TCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAH 448
            ::|..::||::||||..:|.:...: .||.|....|||.||||||.||:||:: .|||.:.||.|
Zfish    24 RKEIKIDGDLVLGGLFPIHEKGMGMDECGRINEDRGIQRLEAMLFAIDQINQDVALLPGVVLGVH 88

  Fly   449 ILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCN------KTQVRKVISGVVGAASSVTSIQVAN 507
            |||.|.:|:|.||.|::|::.|::.:||.|:.|.      :......|:||:|.:.|..||||||
Zfish    89 ILDTCSRDTYALEQALEFVRASLTKVDDTEFICPDGSYALQEDSPLAIAGVIGGSFSSVSIQVAN 153

  Fly   508 LLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGI 572
            |||||:|||:||.|||.:||:|.|::||:||:|.|.||.|||.||::...|:|||.:..|.:||.
Zfish   154 LLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRAFNWTYVSTVASEGDYGE 218

  Fly   573 KAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMR 637
            ...|..|:.....|||||..||:.:.|  |:..:|:.:|::||.||.||.|::|....:.|:::.
Zfish   219 TGIEAFEQQARLRNICIATSEKVGRSS--AKRSSYEAVVRQLLQKPTARVAVLFLRSDDARELIA 281

  Fly   638 AVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            |..|.||  ||.|:.||||.|:..:....|...:|.::::..|:|:..|..||.:||.:.|.|||
Zfish   282 AAARLNA--SFLWVASDGWGAQESIVKGNEFTADGAITLELAAHPIPDFNRYFQTLTPQINHRNP 344

  Fly   703 WFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHR 767
            ||.:|||..|||...|:::|........|..:..:.:.|.:.|.::.||.:||.|.|:||..|.|
Zfish   345 WFKDFWEQKFQCSLGGTSATGAGTPKPPCDQELVIDKSNFEPESKIMFVVNAVYAMAHALHRMQR 409

  Fly   768 DLCGGGPSLCEAMKPTKGADLLK-YLRKVEFE------GLSGDEFRFDGNGDGPARYNIIHFKQS 825
            .||.....||:||:...|..|.: :|..|.|.      ||. .:.:||..|||..||||.:: ||
Zfish   410 TLCANTTRLCDAMRSLDGRKLYRDFLLHVNFRAPFSPAGLE-SQVKFDAYGDGVGRYNIFNY-QS 472

  Fly   826 QAG--QYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFN 888
            ..|  ::.:|:|||:.| .|.||...:.:.| ....|.|.||.||...:.||...||.|||.|..
Zfish   473 VPGSDKFAYVQVGEWAE-SLSLNEGLIGWPR-GADVPTSQCSDPCAPNEMKKMQAGEYCCWICTP 535

  Fly   889 CTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMG 953
            |..|:  :..||..|..|..|..|......|..:||.|:..|.|||||.::.:..|.:.||.|..
Zfish   536 CEPYE--YLPDEFTCMPCAPGQWPRPDLTGCYDLPEDYIMWEDAWAIGPISIACVGFICTLMVFI 598

  Fly   954 VFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLT 1018
            ||:||||||:|:||||||.||||.|:||.|.:||..:.||:.|||.::|.|:|..|.|.|:||||
Zfish   599 VFIRHNDTPLVKASGRELCYILLLGVFMSYVMTFIFIAKPSPIVCTLRRLGLGTSFAVCYSALLT 663

  Fly  1019 KTNRIARIFKAGKQ-SAKRPSFISPKSQLVICACLVSVQILINGVWMVI-APSHAMHHYPTREDN 1081
            |||||||||...|: .|:||.||||.||:.||..|:|||:|:..||::: .|.......|.:...
Zfish   664 KTNRIARIFSGVKEGGAQRPRFISPSSQVFICLSLISVQLLLVSVWLLVEVPGTRRFTTPEKRQT 728

  Fly  1082 LLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYF 1146
            :::..:..|:|.:::.||.:.|:|:|||||..|||.||.|||:|.|||||||||:|||||:|:::
Zfish   729 VILKCNVRDSSMLMSLSYDVVLVVLCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFY 793

  Fly  1147 GTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPS 1211
            .|::...::.|:|.:::|||..|.:.|:|:||::||:.:|::||....:     ||:|.:.:||
Zfish   794 VTSSDYRVQTTTMCISVSLSGFVVLGCMFAPKVHIIMFQPQKNVTSHRL-----NMNRFSVSGP- 852

  Fly  1212 SMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLC---EMATQTISSI 1259
                     |.:.|....:..|..||          :|   |:...|.||:
Zfish   853 ---------ATSYASHASVSAHYVPT----------VCNGREIVDSTTSSL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	194/470 (41%)
		ANF_receptor	422..820	CDD:279440	171/411 (42%)
		NCD3G	861..910	CDD:284890	19/48 (40%)
		7tm_3	945..1181	CDD:278433	119/237 (50%)
grm3	NP_001121815.1	PBP1_mGluR_groupII	31..493	CDD:107370	193/468 (41%)
		ANF_receptor	61..471	CDD:279440	172/415 (41%)
		NCD3G	508..556	CDD:284890	20/49 (41%)
		7tm_3	590..828	CDD:278433	119/237 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720