DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and grm2b

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001274476.1	Gene:	grm2b / 564461	ZFINID:	ZDB-GENE-060201-5	Length:	874	Species:	Danio rerio

Alignment Length:	894	Identity:	363/894 - (40%)
Similarity:	524/894 - (58%)	Gaps:	64/894 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 TQPQRHWPV---KREAIVEGDVILGGLMMVHSR----EDSITCGPIMPQGGIQALEAMLFTIDRI 434
            |.|:...|:   |||.|::||:::|||..||.:    ||   ||.|..:.|||.|||||..:|.|
Zfish    18 TTPRYAPPLAGSKREIIIDGDLVIGGLFPVHEKGKGTED---CGKINEERGIQRLEAMLLALDEI 79

  Fly   435 NRE-QLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCN------KTQVRKVISG 492
            |:: ::||.:.|||||||.|.||:|.||.::.|::.|::.:....:.|.      ..::...|||
Zfish    80 NQDNRILPGLKLGAHILDTCSKDTYALEQSLAFVRASLTKVHQPGFICPDGSNPVPDELPLAISG 144

  Fly   493 VVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMG 557
            |:|.:.|..|||||||||||:|||:||.|||.:||:|.|::||:||:|.|.||.||:.||::...
Zfish   145 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAIAEILRYFN 209

  Fly   558 WSYVSIIYEESNYGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARG 622
            |:|||.:..|.:||....:..::......||||..   ||.|.......|:.:::.|..|..|:.
Zfish   210 WTYVSTVASEGDYGETGIDAFQQEARVRQICIATS---VKVSRSVNQGNYETVIRSLQQKANAKV 271

  Fly   623 AIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFE 687
            .|:|...::.|:::.|..|.|.|  |.|:.||||.|:..|..|.|....|..:::..:..:|.||
Zfish   272 VILFTRSEDARELLAAAARMNVT--FIWVASDGWGAQESVVHDSEKAANGAFTIELASYSIREFE 334

  Fly   688 EYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDF--EDQLQF 750
            :||..||.|.|.|||||.|:||.:|.|          |.....|.:|   |.:|..|  |.::.|
Zfish   335 DYFTKLTPELNTRNPWFREYWEHNFGC----------NLQDHGCASK---SLRNDLFKPESKIMF 386

  Fly   751 VSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLK-YLRKVEFEGL-----SGDEFRFDG 809
            |.:||.|.||||.:|.:.:|.....:|:||||..|....: ::.|.:|:..     :.:..||..
Zfish   387 VVNAVYAMAYALHNMRQAVCPNTTKVCDAMKPGNGKRFYREFILKTKFDAPFRPADTENVVRFTS 451

  Fly   810 NGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAK 874
            .||...||||.|::: :..:|.:.|||.:.:| |.||.:.|.:  .....|.|.||.||...:||
Zfish   452 LGDSLGRYNIFHYRK-EDNKYVYRKVGYWAQG-LVLNTSLVPW--AGGVAPTSQCSDPCQPNEAK 512

  Fly   875 KYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMA 939
            ....|:.|||.|..|..:|...  :|..|..|..|..|.|:...|..:||.|:....|||:|.:.
Zfish   513 SMQPGDVCCWICIPCQPHQFLL--NEFTCVDCGFGQWPLANLTGCYELPEEYIHWSDAWAVGPVT 575

  Fly   940 FSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFG 1004
            .:..|:|.||.|.|:|:|.||||:|:|||||||||||.|:.:||.:||..:.||:..|||::|.|
Zfish   576 IACLGMLCTLAVAGLFLRSNDTPVVKASGRELSYILLFGVLLCYAMTFIYIAKPSAFVCALRRLG 640

  Fly  1005 VGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVI-AP 1068
            :|..|.|.|:|||||||||||||...:.||:||.||||.||:.|||.|:|.|:|:..||::: ||
Zfish   641 LGTSFAVCYSALLTKTNRIARIFGGARDSAQRPRFISPASQVAICAALISAQLLVALVWLLVEAP 705

  Fly  1069 SHAMHHYPTREDNL-LVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMY 1132
            .......|.|.|.: |.|:| :|:|.:::.||...||::||.||..|||.||.|||:|.||||||
Zfish   706 GVRKEVGPDRRDVVTLKCNS-LDSSMLVSLSYNCILIILCTFYAFKTRKCPENFNEAKFIGFTMY 769

  Fly  1133 TTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPP 1197
            |||:|||||.|:::.||:...::.|:|.:::|||.||.:.|||:||::|||.:|::||......
Zfish   770 TTCIIWLAFQPIFYVTASDYRVQTTTMCISVSLSGSVVLGCLFAPKIHIILFQPQKNVTSLRAK- 833

  Fly  1198 RYGNMHRTAGTGPS---SMMAAAVVTAATCAQEEKIQKHITPTNTENSL 1243
              .|...:|.|.||   |..:|:.:....|...|.:.      :|.:||
Zfish   834 --DNRFSSAVTAPSSTYSQASASTIVPTVCNGREVVD------STTSSL 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	179/472 (38%)
		ANF_receptor	422..820	CDD:279440	156/412 (38%)
		NCD3G	861..910	CDD:284890	17/48 (35%)
		7tm_3	945..1181	CDD:278433	127/237 (54%)
grm2b	NP_001274476.1	PBP1_mGluR_groupII	37..487	CDD:107370	179/472 (38%)
		ANF_receptor	67..462	CDD:279440	156/412 (38%)
		NCD3G	499..547	CDD:284890	18/49 (37%)
		7tm_3	581..818	CDD:278433	127/237 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720