DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and casr

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_017211901.1	Gene:	casr / 560607	ZFINID:	ZDB-GENE-050119-8	Length:	956	Species:	Danio rerio

Alignment Length:	991	Identity:	274/991 - (27%)
Similarity:	464/991 - (46%)	Gaps:	142/991 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GDVILGGLMMVH----SREDSITCGPIMPQ------GGIQALEAMLFTIDRINREQ-LLPNITLG 446
            ||::||||..:|    |::..:...|...:      .|.:.|::|:|.|:.||... ||||||||
Zfish    34 GDILLGGLFPMHFGVASKDQDLAARPESTECVRYNFRGFRWLQSMIFAIEEINNSSTLLPNITLG 98

  Fly   447 AHILDDCDKDSYGLEMAVDFI-KGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANLLR 510
            ..|.|.|:..|..||.::.|: :..|.:::..|: ||.|........||||:.|..|..||:||.
Zfish    99 YRIFDTCNTVSKALEASLSFVAQNKIDSLNLDEF-CNCTGNIPSTIAVVGASGSAVSTAVADLLG 162

  Fly   511 LFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAF 575
            ||.|||:||.|:|..||||.:::.|.||||:|.||..||..|::...|::|..|..:..||....
Zfish   163 LFYIPQISYASSSRLLSNKNQYKSFMRTIPTDEYQAIAMAAIIEHFQWNWVIAIASDDEYGRPGI 227

  Fly   576 EELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKL---LTKPRARGAIIFGSDQEVRQVMR 637
            |:.|..:...:|||.:...:.:....||       :::|   :....|:..::|.|..::..:::
Zfish   228 EKFENEMFHRDICIDLNVLISQYVDEAE-------IRRLADRIQNSSAKVIVVFASGPDIEPLVK 285

  Fly   638 AVRRANATGSFSWIGSDGWSARNLVS-DDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRN 701
            .:.|.|.|... |:.|:.|::.:||: .:|...:.||:....:|..:.||:::...:..:.:..|
Zfish   286 EMVRRNITDRV-WLASEAWASSSLVAKPEYLDVMGGTIGFALRAGHIPGFKDFLQQVHPKKSSHN 349

  Fly   702 PWFVEFWEDHFQCRYP----------GSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQF-----V 751
            .:..||||:.|.|...          ||||     :...||.:|.::...|.:.|....     |
Zfish   350 EFVREFWEETFNCYLEDSPRNADSENGSTS-----FRPLCTGEEDIASVETPYLDYTHLRISYNV 409

  Fly   752 SDAVMAFAYALRDMHRDLCGGGPSL-----CEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNG 811
            ..||.|.|.||:|:.  .|..|..|     |..::..:...:||.||.:.|....|:..|||...
Zfish   410 YVAVYAIAQALQDIL--TCTPGKGLFSNGSCADIRKVEAWQVLKQLRHLNFIDSMGERVRFDNGS 472

  Fly   812 DGPARYNIIHFKQS-QAGQYHWVKVGEYT-----EGELRLNMTEVKFK-RLSP---------KPP 860
            :..|.|.||::.:| :.|...:.:||.|:     ..:|.::.:::.:. ||:.         :.|
Zfish   473 ELSANYTIINWHRSPEDGSVVFKEVGYYSIHNKNVAKLSIDKSKILWNGRLTEVMCCFSFLYQVP 537

  Fly   861 ESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPE 924
            .|.||:.|..|..|..::|| :||:.|..|:..:.....|.:.|..|...:..:.:...|.....
Zfish   538 FSNCSVECEPGTRKGIIDGEPTCCFECTECSDGEYSDHKDASFCVKCPNNSWSNGNHTSCFLKQI 602

  Fly   925 IYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFAL 989
            .:|.....:.|....|:..|:|:|.||:||||:..|||||:||.||||::||..:..|:..:...
Zfish   603 EFLSWTEPFGIALALFAVLGVLLTAFVLGVFVQFRDTPIVKASNRELSFLLLFSLICCFSSSLIF 667

  Fly   990 VLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPK-----SQLVIC 1049
            :.:|.:..|.:::...|..|.:..:.:|.||||:..:|:     ||.|:.:..|     .|.::.
Zfish   668 IGEPQDWTCRVRQPAFGISFVLCISCILVKTNRVLLVFE-----AKIPTSLHRKWWGLNLQFLLV 727

  Fly  1050 ACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCD--SYIDASYMIAFSYPIFLIVICTVYAV 1112
            .....||::|..||:..||..:..:|...|...:.|:  |.:...::|  .|...|..||..:|.
Zfish   728 FLFTFVQVMICVVWLYNAPPGSYKNYDIDEIIFITCNEGSMMALGFLI--GYTCLLAAICFFFAF 790

  Fly  1113 LTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVT-IACLFS 1176
            .:||:||.|.|:|.|.|:|....::|::|:|.||.|....   ::::.|...|::|.: :||:|.
Zfish   791 KSRKLPENFTEAKFITFSMLIFFIVWISFIPAYFSTYGKF---VSAVEVIAILASSFSLLACIFF 852

  Fly  1177 PKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTEN 1241
            .|:||||::|.||..:.:          ...|...:..|||..|.          :|       :
Zfish   853 NKVYIILLKPSRNTIEEV----------RCSTAAHAFKAAAKATL----------RH-------S 890

  Fly  1242 SLKTKKLCEMATQTISSIITSLDINAYNQIPYADQYVPNNATTATTTPTDKGSGNGNSNSNSNTN 1306
            |...|:...:...:.||                    |:::.:..|        |||...:.:|.
Zfish   891 SGFRKRSSSVGGSSASS--------------------PSSSISMKT--------NGNEMESPSTR 927

  Fly  1307 GSSNSNSNSNGDGDVA 1322
            ...:....|.|.|.|:
Zfish   928 RHGSKPRVSFGSGTVS 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	147/495 (30%)
		ANF_receptor	422..820	CDD:279440	129/423 (30%)
		NCD3G	861..910	CDD:284890	15/49 (31%)
		7tm_3	945..1181	CDD:278433	77/243 (32%)
casr	XP_017211901.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810