DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and olfcq2

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_021328981.1	Gene:	olfcq2 / 557054	ZFINID:	ZDB-GENE-050419-264	Length:	869	Species:	Danio rerio

Alignment Length:	865	Identity:	253/865 - (29%)
Similarity:	404/865 - (46%)	Gaps:	106/865 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 EGDVILGGLMMVHS----REDSITCGPIMPQ------GGIQALEAMLFTIDRIN-REQLLPNITL 445
            :|:.|:|||..|.:    .|.|.|..|.:||      ...|....|:|.|:.|| ..:|||||||
Zfish    43 DGEFIIGGLFEVQNLKVFPELSFTNEPELPQCEEFYMASFQQALTMVFAINEINSSNKLLPNITL 107

  Fly   446 GAHILDDCDKDSYGLEMAVDFIKGS--ISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANL 508
            |..|.|:|.:.......|:..:.|:  .||:.     |  |....|| |:||...|..||.::::
Zfish   108 GYQIYDNCLRLGVAFRAAMSLVSGTEEFSNLS-----C--TGPPPVI-GIVGDPGSTQSITISSV 164

  Fly   509 LRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIK 573
            |.|:|:|.|||::|...||:::::..|.||||||.:||:|||:|::..||::|.::|...:|||.
Zfish   165 LGLYRVPMVSYYATCSCLSDRKKYPSFFRTIPSDAFQVRAMVQILRHFGWTWVGLLYSNDDYGIY 229

  Fly   574 AFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDN---IVQKL---LTKPRARGAIIFGSDQEV 632
            |.:..::.:.....|:|..|.|          .|||   .:|::   :.|..||..:.|.:|  :
Zfish   230 AAQSFQQEMQILGGCVAFSEML----------PYDNNGRDIQRIAGVIQKSTARVVVAFSTD--L 282

  Fly   633 RQVMRAVRRANATGSFSWIGSDGWSARN-LVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVE 696
            ..:|..:...|.||. .||.|:.|:... |.:..|.|.:.|||.:..:...::|..|:..:|..:
Zfish   283 ASLMDELLLQNVTGK-QWIASEAWTTTPVLQTPQYLPLLGGTLGIAIRRGQIQGLYEFLKNLRPD 346

  Fly   697 NNQRNPWFVEFWEDHFQCRYP---GSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQF-----VSD 753
            .|.:|.....|||..|.|::.   ............:|:.:|.|:...|.:.|..:.     |..
Zfish   347 KNPKNSTIRIFWETMFGCKFEVGGKKVDEEQERGRNKCSGQEDLNNSETAYTDVSELRASYNVYK 411

  Fly   754 AVMAFAYALRDMHRDLCGGGP---SLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPA 815
            ||.|.|:||.|:.:...|.||   :.|..:...|...|:.|::.|:|....||...||.|||..|
Zfish   412 AVYALAHALHDLVKCEEGKGPFTGNSCADISNLKPWQLVHYIQNVKFTTGFGDHVSFDENGDALA 476

  Fly   816 RYNIIHFKQSQAGQ--YHWVKVGEYTEGELRLNMT----------EVKFKRLSPKPPESVCSLPC 868
            .|:::::.....|.  .|.|.| .|.|..|...:|          |.|      |||:||||..|
Zfish   477 IYDVMNWHPRSDGSIIVHVVGV-VYEEAILGKVLTLDEDALFWNFETK------KPPDSVCSESC 534

  Fly   869 LVGQAKKYVEG-ESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESA 932
            ..|..:...:| ..||:.|..|...:|.:..|...|.:|............|.|....:|..:..
Zfish   535 PPGTRRARKKGLPVCCFDCLPCGDGEISNTTDSPECFICPEDFWSSPENDRCVPKEMEFLSYDDP 599

  Fly   933 WAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIV 997
            ..|.....|..|....:.|:.:|..|::||:|||:..|||::||..:..|:......:.:|....
Zfish   600 LGISLTTASLLGTCFCVLVLVIFAYHHNTPVVRANNSELSFLLLVSLKFCFLCVLLFIGRPQLWT 664

  Fly   998 CAIQRFGVGFCFTVVYAALLTKTNRIARIFKA----GKQSAKRPSFISPKSQLVICACLVSVQIL 1058
            |.::....|..|.:..:::|.||..:..:||:    ||.|.|  .|.|.:.:..:.| |.|.|:.
Zfish   665 CQLRHAVFGISFVLCISSILVKTMVVIAVFKSSRPEGKTSIK--WFGSAQQRGTVIA-LTSAQVA 726

  Fly  1059 INGVWMVIAPSHAMHHYPTREDNLLVCDSYID------------ASYMIAFSYPIFLIVICTVYA 1111
            |..||:..|.       ||...|    :.||.            |.:.:...|...|..:..:.|
Zfish   727 ICTVWLSSAS-------PTPHKN----NQYIHSKIVYECAIGSVAGFSLLLGYIGLLAAVSFLLA 780

  Fly  1112 VLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASV-TIACLF 1175
            .:.||:|:.|||:|.|.|:|...|.:|:||||.|..:.....:.:...::   |::|. .:|.:|
Zfish   781 FMARKLPDNFNEAKFITFSMLIFCAVWIAFVPAYVSSPGKYAVAVEIFAI---LASSFGLLAAIF 842

  Fly  1176 SPKLYIILIRPERNVRQSMM 1195
            :||.|||::.||||.::::|
Zfish   843 APKCYIIILHPERNTKKAIM 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	149/486 (31%)
		ANF_receptor	422..820	CDD:279440	130/418 (31%)
		NCD3G	861..910	CDD:284890	15/49 (31%)
		7tm_3	945..1181	CDD:278433	69/252 (27%)
olfcq2	XP_021328981.1	Periplasmic_Binding_Protein_Type_1	42..518	CDD:324556	150/496 (30%)
		NCD3G	528..579	CDD:311495	15/50 (30%)
		7tmC_V2R_pheromone	599..851	CDD:320410	75/268 (28%)
		TM helix 1	599..624	CDD:320410	5/24 (21%)
		TM helix 2	636..657	CDD:320410	6/20 (30%)
		TM helix 3	666..690	CDD:320410	5/23 (22%)
		TM helix 4	715..731	CDD:320410	5/16 (31%)
		TM helix 5	758..784	CDD:320410	4/25 (16%)
		TM helix 6	792..815	CDD:320410	11/22 (50%)
		TM helix 7	820..845	CDD:320410	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910