DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and Vom2r47

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_006232524.2	Gene:	Vom2r47 / 365807	RGDID:	1559813	Length:	908	Species:	Rattus norvegicus

Alignment Length:	896	Identity:	237/896 - (26%)
Similarity:	407/896 - (45%)	Gaps:	112/896 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 VILGGLMMVHSR----------EDSITCGPIMPQG----GIQALEAMLFTIDRIN-REQLLPNIT 444
            :::|||..||.|          .:|..|     :|    |.:.::.|:.||..|| |:.:|||.|
  Rat    50 MVIGGLFPVHYRTIPKIDPDEEPESAMC-----EGFNFRGFRWMKTMIHTIKEINERKDILPNHT 109

  Fly   445 LGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCN-KTQVRKVISGVVGAASSVTSIQVANL 508
            ||..|.|.|...|..:|....|:.|      ..||..| :....|.::|::|:..|..|:..:.:
  Rat   110 LGYQIFDTCFSISKTVESTFVFLTG------QEEYKPNFRNSSGKYLAGIIGSGGSSLSVASSRI 168

  Fly   509 LRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIK 573
            |.::.:.||.|.|:|..||:..||..|.||||||..|.:|||.::|..||.:|..|..:.:||..
  Rat   169 LEVYYMSQVGYTSSSSILSDHFRFPTFYRTIPSDKIQTEAMVNLIKHFGWVWVGAIAADDDYGKY 233

  Fly   574 AFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDN-IVQKLLTKPR---ARGAIIFGSDQEVRQ 634
            ..:..:|.|.|.|:|:|..|.:.|        .|.| .:||.:...:   |:..:::.:|.::|.
  Rat   234 GIKSFKEKLERSNLCVAFSETIPK--------VYSNEKMQKAINAVKSSTAKVVVLYATDIDLRP 290

  Fly   635 VMRAVRRANATGSFSWIGSDGWSARNLVS-DDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENN 698
            .:..|...|.|.. :||.|:.|....|:: .:|.|...||:......:.:.|.:|:...:....:
  Rat   291 FVLEVVHHNITDR-TWIASEAWITSALIAKPEYFPYFGGTIGFAIPRSVIPGLKEFLYDVHPSKD 354

  Fly   699 QRNPWFVEFWEDHFQCRYPGSTSTPYN-----NYT-----------KQCTTKERLSRQNTDFEDQ 747
            ..:...:|||:..|.|.:|.| |.|||     |.|           :.||.:|:|......:.|.
  Rat   355 PNDVLTIEFWQTAFNCTWPNS-SVPYNVDYRGNMTGKEDRFYAMSDRLCTGEEKLEDLKNTYLDT 418

  Fly   748 LQF-----VSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGA---------DLLKYLRKVEFE 798
            .|.     |..||...|:||..:.|         |:..:|....         :|:.|:.::||.
  Rat   419 SQLRITNNVKQAVYLLAHALDRLSR---------CDVPQPDVKCSQIPNFDPFELMIYIMRMEFT 474

  Fly   799 GLSGDEFRFDGNGD-GPARYNIIHFKQSQAGQYHWVKVGEY----TEGELRLNMTEVKF-KRLSP 857
            ...|.:...|.:|| ....|:|::::...||:..:||.|||    ::.||.|:.....| ...|.
  Rat   475 THDGRKIELDRSGDVKNGYYDILNWQMDDAGEIAFVKFGEYKFTSSKYELVLSKNSTLFWNTESS 539

  Fly   858 KPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRP 921
            :.|:|.|:..|..|..|...:|: :||:.|..|....:.....:..|..|......:|.|..|.|
  Rat   540 ELPDSFCTKLCPPGTRKGIRQGKPTCCFDCIPCADGYVSEKPGQRECDPCSEDDWSNAEKSKCVP 604

  Fly   922 IPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVT 986
            ....:|..|.|.....:..|..|.||.:.|..|:|.|..||:|:|:.||||:.:...:.:....:
  Rat   605 KLVEFLSYEEALGFTLVILSIFGALVVMAVTVVYVIHRHTPLVKANDRELSFFIQMSLVITVLSS 669

  Fly   987 FALVLKPTNIVCAIQR--FGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVIC 1049
            ...:.||.|..|..::  ..:|||..:  :::|.||..:...::..|...:..|......:|::.
  Rat   670 MLFIGKPCNWSCMARQVTLALGFCLCL--SSILGKTISLFFAYRISKSKTRLISMHPIFRKLIVL 732

  Fly  1050 ACLVSVQILINGVWMVIAPSHAMHHY-PTREDNLLVC-DSYIDASYMIAFSYPIFLIVICTVYAV 1112
            .|:|. :|.:...::|:.|.....:. |.....:..| :..|:..|.| |.:.:.|.::|.:...
  Rat   733 ICVVG-EIGVCTAYLVLEPPRMFKNIEPQNVKIIFECNEGSIEFLYSI-FGFNVLLALLCFLTTF 795

  Fly  1113 LTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASV-TIACLFS 1176
            :.|::|:.:.|.|.|.|.|....::|::|||.|..|.....:.:...::   |::|. .:.|:|.
  Rat   796 VARQLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTKGKFKVAVEIFAI---LASSYGLLGCVFL 857

  Fly  1177 PKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQE 1227
            ||.:|||:||:||..:            |.|....::..:..:|:|:.:.|
  Rat   858 PKCFIILLRPKRNTDE------------TVGGRVPTLDKSIQLTSASVSSE 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	142/507 (28%)
		ANF_receptor	422..820	CDD:279440	121/435 (28%)
		NCD3G	861..910	CDD:284890	12/49 (24%)
		7tm_3	945..1181	CDD:278433	59/240 (25%)
Vom2r47	XP_006232524.2	PBP1_CaSR	51..534	CDD:380587	142/512 (28%)
		NCD3G	542..595	CDD:400103	13/52 (25%)
		7tmC_V2R-like	615..867	CDD:320407	65/258 (25%)
		TM helix 1	616..640	CDD:320407	6/23 (26%)
		TM helix 2	652..673	CDD:320407	4/20 (20%)
		TM helix 3	682..704	CDD:320407	5/23 (22%)
		TM helix 4	729..745	CDD:320407	4/16 (25%)
		TM helix 5	772..795	CDD:320407	6/23 (26%)
		TM helix 6	807..829	CDD:320407	8/21 (38%)
		TM helix 7	834..859	CDD:320407	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910