DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm2a

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_005166174.1	Gene:	grm2a / 336153	ZFINID:	ZDB-GENE-030131-8097	Length:	894	Species:	Danio rerio

Alignment Length:	956	Identity:	388/956 - (40%)
Similarity:	547/956 - (57%)	Gaps:	98/956 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 RSGRHRGRHLPLNNMNLMLPLSSADGSGKYLRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGD 394
            ||...|| |.|...::|.|.|       ..|...|.:::...   |.|...     |:|.:::||
Zfish    11 RSAHFRG-HGPSWPLHLTLLL-------LLLARTPQALAIPG---YNTDTS-----KKEIVMDGD 59

  Fly   395 VILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINR-EQLLPNITLGAHILDDCDKDS 457
            :::|||..||.: |.:..||.|..|.|||.|||||..:|:||: :|:||.:||||||||.|.||:
Zfish    60 LVIGGLFPVHHKGEGAQDCGRINTQRGIQRLEAMLLALDKINQDDQILPGVTLGAHILDTCSKDT 124

  Fly   458 YGLEMAVDFIKGSISNIDDAEYHCN------KTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQ 516
            |.||.:::|::.|::.:||:||.|.      ...|...||||:|.:.|..|||||||||||:|||
Zfish   125 YALEQSLEFVRASLTKVDDSEYTCPDGSYAIHDDVPLAISGVIGGSYSDVSIQVANLLRLFQIPQ 189

  Fly   517 VSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GIKAFEEL 578
            :||.|||.:||:|.|::||:||:|.|.||.|||.||::...|:|||.:..|.:|   ||.||::.
Zfish   190 ISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIDAFQQE 254

  Fly   579 EELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRAN 643
            ...|   .||||...|:   |...:..:||.:::.||.|..|:..|:|...::.|:::.|.:|.|
Zfish   255 ARAL---QICIATSAKV---SRSMDQYSYDGVIRSLLQKSNAKVVILFTRSEDARELLVAAKRMN 313

  Fly   644 ATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFW 708
            .  ||.|:.||||.|:.:|....|...:|..:::..:..:..|..||.:|...||.|||||.|||
Zfish   314 V--SFIWVASDGWGAQEVVVRGSESVADGAFTIELASYTIPEFAAYFTNLNPYNNTRNPWFREFW 376

  Fly   709 EDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGG 773
            |:.|||.....|          | .|..|.....:.|.::.||.:||.|.|.||..|.:.||...
Zfish   377 ENKFQCSLHDIT----------C-GKHSLRDGKFEQESKIMFVVNAVYAMANALHHMRQALCANS 430

  Fly   774 PSLCEAMKPTKGADLLK-YLRKVEFEGLSGDEFR---------FDGNGDGPARYNIIHFKQSQAG 828
            ..||.||||..|..|.| |:.|.:|:.    .||         ||..||...||||.|: ..:..
Zfish   431 TKLCSAMKPVNGKRLYKDYILKTKFDA----PFRPADTDNIIHFDAYGDSLGRYNIFHY-HKEND 490

  Fly   829 QYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQ 893
            :|.:.||| |...:|.||.|.:.::  |...|.|.||.||...:.|....|:.|||.|..|..||
Zfish   491 EYVYRKVG-YWAQDLTLNTTLIPWE--SQAVPTSQCSDPCRKNEIKSMQPGDVCCWICIPCQPYQ 552

  Fly   894 IRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRH 958
              :..||..|..|..|..|..:...|..:||.|:..|.|||||.::.:..|:|.||||:|:|:::
Zfish   553 --YLLDEFTCADCSFGQWPLDNLTGCYDLPEEYIHWEDAWAIGPVSIACLGMLCTLFVIGLFLKN 615

  Fly   959 NDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRI 1023
            |:||:|:|||||||||||.|:.:||.:||..:.||:.:||.::|.|:|..|.|.|:|||||||||
Zfish   616 NETPVVKASGRELSYILLLGVLLCYFMTFIYISKPSAVVCTLRRLGLGTSFAVCYSALLTKTNRI 680

  Fly  1024 ARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVI-APSHAMHHYPTREDNL-LVCD 1086
            ||||...|..|:||.||||.||:.|||.|:|.|:|:..||::: ||.......|.|.|.: |.|:
Zfish   681 ARIFNGVKDGAQRPRFISPASQVAICAALISCQLLVVVVWLLVEAPGVRKEVSPERRDVVTLKCN 745

  Fly  1087 SYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANH 1151
            |. |:|.:::.:|...||::||.||..|||.||.|||:|.|||||||||:|||||.|:::.||:.
Zfish   746 SK-DSSMLMSLTYNCVLIILCTFYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFQPIFYVTASD 809

  Fly  1152 VPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAA 1216
            ..::.|:|.:::|||.||.:.|||:||::|||.:|::||...    |......:..|||.|..:.
Zfish   810 YRVQTTTMCISVSLSGSVVLGCLFAPKIHIILFQPQKNVTTL----RVATTRFSVTTGPGSSFSQ 870

  Fly  1217 AVVTAATCAQEEKIQKHITPTNTENSLKTKKLC---EMATQTISSI 1259
            |..:            :|.||          :|   |:...|.||:
Zfish   871 ASAS------------NIVPT----------VCNGREVVDSTTSSL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	194/474 (41%)
		ANF_receptor	422..820	CDD:279440	171/417 (41%)
		NCD3G	861..910	CDD:284890	18/48 (38%)
		7tm_3	945..1181	CDD:278433	124/237 (52%)
grm2a	XP_005166174.1	PBP1_mGluR_groupII	58..508	CDD:107370	194/474 (41%)
		NCD3G	520..569	CDD:311495	19/50 (38%)
		7tm_GPCRs	589..842	CDD:333717	132/253 (52%)
		TM helix 1	590..614	CDD:320095	12/23 (52%)
		TM helix 2	626..647	CDD:320095	13/20 (65%)
		TM helix 3	656..678	CDD:320095	11/21 (52%)
		TM helix 4	704..720	CDD:320095	7/15 (47%)
		TM helix 5	747..770	CDD:320095	8/23 (35%)
		TM helix 6	779..804	CDD:320095	19/24 (79%)
		TM helix 7	811..836	CDD:320095	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820