DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and Tas1r1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_445757.1	Gene:	Tas1r1 / 29407	RGDID:	61891	Length:	840	Species:	Rattus norvegicus

Alignment Length:	869	Identity:	232/869 - (26%)
Similarity:	379/869 - (43%)	Gaps:	154/869 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GDVILGGLMMVH---------------SREDSITCGPIMPQGGIQALEAMLFTIDRINREQ-LLP 441
            ||.:|.||..:|               .|.||..      ..|....:||.||::.||... |||
  Rat    35 GDFLLAGLFSLHGDCLQVRHRPLVTSCDRPDSFN------GHGYHLFQAMRFTVEEINNSSALLP 93

  Fly   442 NITLGAHILDDCDKDS--YGLEMAVDFIKG--SISNIDDAEYHCNKTQVRKVISGVVGAASSVTS 502
            |||||..:.|.|.:.:  |. .:.|..::|  .|....|...|.:|      :...:|..::..:
  Rat    94 NITLGYELYDVCSESANVYA-TLRVLALQGPRHIEIQKDLRNHSSK------VVAFIGPDNTDHA 151

  Fly   503 IQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEE 567
            :..|.||..|.:|.|||.::|..||.|::|..|.||:|||.:||:.||::::..||.::|:|...
  Rat   152 VTTAALLGPFLMPLVSYEASSVVLSAKRKFPSFLRTVPSDRHQVEVMVQLLQSFGWVWISLIGSY 216

  Fly   568 SNYGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEV 632
            .:||....:.||||.....||:|.|: :|..|....|....:::|. |.:.|....::|.:....
  Rat   217 GDYGQLGVQALEELAVPRGICVAFKD-IVPFSARVGDPRMQSMMQH-LAQARTTVVVVFSNRHLA 279

  Fly   633 RQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVEN 697
            |...|:|..||.||.. |:.|:.|:....::.                  |.|.:.....|.|..
  Rat   280 RVFFRSVVLANLTGKV-WVASEDWAISTYITS------------------VTGIQGIGTVLGVAV 325

  Fly   698 NQRN-PWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQ------------LQ 749
            .||. |...||.|.:.:......::.|..::   |:|.: |.|:...|..:            ..
  Rat   326 QQRQVPGLKEFEESYVRAVTAAPSACPEGSW---CSTNQ-LCRECHTFTTRNMPTLGAFSMSAAY 386

  Fly   750 FVSDAVMAFAYALRDM---HRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNG 811
            .|.:||.|.|:.|..:   ..::|..||     :.|.:   ||:.:.||.|. |..:...||.||
  Rat   387 RVYEAVYAVAHGLHQLLGCTSEICSRGP-----VYPWQ---LLQQIYKVNFL-LHENTVAFDDNG 442

  Fly   812 DGPARYNIIHFKQSQAGQYHW---------VKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLP 867
            |....|:||        .:.|         :.....:...|.:|.|::::...:.:.|.|||:..
  Rat   443 DTLGYYDII--------AWDWNGPEWTFEIIGSASLSPVHLDINKTKIQWHGKNNQVPVSVCTTD 499

  Fly   868 CLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQ--YCRPIPEIYLRPE 930
            ||.|..:..|....||:.|..|......:..:...|:.|  ||...|.|:  .|.|....:|
  Rat   500 CLAGHHRVVVGSHHCCFECVPCEAGTFLNMSELHICQPC--GTEEWAPKESTTCFPRTVEFL--- 559

  Fly   931 SAW--AIGAMAFSATGILVTLFV--MGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVL 991
             ||  .|..:..:|..:|:.|.|  .|:|..|..||:||::|..|.:::|..:.......::...
  Rat   560 -AWHEPISLVLIAANTLLLLLLVGTAGLFAWHFHTPVVRSAGGRLCFLMLGSLVAGSCSFYSFFG 623

  Fly   992 KPTNIVCAIQR--FGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQ------LVI 1048
            :||...|.:::  |.:|  |.:..:.|..::.::..|||.   |.|.|:|....:|      .||
  Rat   624 EPTVPACLLRQPLFSLG--FAIFLSCLTIRSFQLVIIFKF---STKVPTFYRTWAQNHGAGLFVI 683

  Fly  1049 CACLVSVQILINGVWMVI-APSHAMHHYPTREDN------LLVCDSYIDASYMIAFSYPIFLIVI 1106
            .:.  :|.:||...|:|: .|.      ||||..      :|.|.......:::||::.|.|.:.
  Rat   684 VSS--TVHLLICLTWLVMWTPR------PTREYQRFPHLVILECTEVNSVGFLLAFTHNILLSIS 740

  Fly  1107 CTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAF---VPLYFGT---ANHVPLRITSMSVTISL 1165
            ..|.:.|.:::||.:||:|.:.|::....|.|:||   ..:|.|:   |.:|...:|::|...|
  Rat   741 TFVCSYLGKELPENYNEAKCVTFSLLLNFVSWIAFFTMASIYQGSYLPAVNVLAGLTTLSGGFS- 804

  Fly  1166 SASVTIACLFSPKLYIILIRPERN 1189
                   ..|.||.|:||.|||.|
  Rat   805 -------GYFLPKCYVILCRPELN 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	130/498 (26%)
		ANF_receptor	422..820	CDD:279440	116/418 (28%)
		NCD3G	861..910	CDD:284890	13/48 (27%)
		7tm_3	945..1181	CDD:278433	68/258 (26%)
Tas1r1	NP_445757.1	PBP1_Taste_receptor	31..485	CDD:107358	132/504 (26%)
		ANF_receptor	73..456	CDD:279440	118/431 (27%)
		NCD3G	493..543	CDD:284890	15/51 (29%)
		7tm_3	581..813	CDD:278433	66/252 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000