DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mtt and GRM8

DIOPT Version :9

Sequence 1:NP_001260806.1 Gene:mtt / 35832 FlyBaseID:FBgn0050361 Length:1472 Species:Drosophila melanogaster
Sequence 2:NP_001358015.1 Gene:GRM8 / 2918 HGNCID:4600 Length:928 Species:Homo sapiens


Alignment Length:901 Identity:389/901 - (43%)
Similarity:560/901 - (62%) Gaps:81/901 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   391 VEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDC 453
            |:||:|||||..||:: |..:.||.:..:.||..|||||:.||:||:: .||.|||||..|||.|
Human    42 VDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC 106

  Fly   454 DKDSYGLEMAVDFIKGSISNIDDAEYHCNK------TQVRKVISGVVGAASSVTSIQVANLLRLF 512
            .:|:|.||.::.|::..|.. |.::..|..      |:..| ||||:|||:|..||.|||:||||
Human   107 SRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTKPDK-ISGVIGAAASSVSIMVANILRLF 169

  Fly   513 RIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GIKA 574
            :|||:||.||:||||:..|:::|||.:|.|.||.:|||:||..:||:|||.:..|.||   |::|
Human   170 KIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEA 234

  Fly   575 FEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAV 639
            |.::...:.  .:|||..:|:.::....|   ::.|:::||..|.||..|:|.::.::|:::.|.
Human   235 FTQISREIG--GVCIAQSQKIPREPRPGE---FEKIIKRLLETPNARAVIMFANEDDIRRILEAA 294

  Fly   640 RRANATGSFSWIGSDGWSARNLVSDDYEPE--VEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            ::.|.:|.|.|||||.|.::  ::..|:.|  .||.:::.|:...:.||:.||.|.|:.||:||.
Human   295 KKLNQSGHFLWIGSDSWGSK--IAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357

  Fly   703 WFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMH 766
            ||.||||::|.|:. ||.. ..|::.|:||..||::|.:: :.|.::|||.|||.:.||||.:||
Human   358 WFAEFWEENFGCKL-GSHG-KRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420

  Fly   767 RDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFK-QSQAGQY 830
            :|||.|...||..|....|.:||.|:|.|.|.|.:|....|:.|||.|.||:|..:: .:::.:|
Human   421 KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEY 485

  Fly   831 ----HWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCT- 890
                ||.       .:|.|.:.::::.......|.|||||||..|:.||.|:|..|||||..|. 
Human   486 KVIGHWT-------NQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEG 543

  Fly   891 -TYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGV 954
             .||:    ||..|:||.|...|:.::..|:.||.|.|...|.||:..:..:..||:.|.||:..
Human   544 YNYQV----DELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVT 604

  Fly   955 FVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQR--FGVGFCFTVVYAALL 1017
            |||:|||||||||||||||:||.|||:||.:||.::..|..|:|:.:|  .|:|.||:  |||||
Human   605 FVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFS--YAALL 667

  Fly  1018 TKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY------- 1075
            ||||||.|||:.||:|...|.||||.|||||...|:|||:|...||.|:.|.|.:..|       
Human   668 TKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLD 732

  Fly  1076 PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLA 1140
            |.:...:|.|| ..|.|.:.:..|.|.|:|.|||||:.||.:||.|||:|.|||||||||:||||
Human   733 PEKARGVLKCD-ISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLA 796

  Fly  1141 FVPLYFGTANHVP---LRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNM 1202
            |:|::||||....   ::.|:::|::||||||::..|:.||:|||:..||:||::          
Human   797 FIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQK---------- 851

  Fly  1203 HRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISS 1258
                    ......||||||| .|.:.|||.....|.|  :|: :||| :.:|.||
Human   852 --------RKRSFKAVVTAAT-MQSKLIQKGNDRPNGE--VKS-ELCE-SLETNSS 894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mttNP_001260806.1 Periplasmic_Binding_Protein_Type_1 73..>152 CDD:299141
PBP1_mGluR 393..847 CDD:107357 194/472 (41%)
ANF_receptor 422..820 CDD:279440 174/410 (42%)
NCD3G 861..910 CDD:284890 26/50 (52%)
7tm_3 945..1181 CDD:278433 130/247 (53%)
GRM8NP_001358015.1 PBP1_mGluR_groupIII 40..504 CDD:380599 195/479 (41%)
Glutamate binding. /evidence=ECO:0000250 177..179 0/1 (0%)
NCD3G 512..562 CDD:369426 27/53 (51%)
7tmC_mGluR8 582..892 CDD:320570 157/335 (47%)
TM helix 1 583..607 CDD:320570 8/23 (35%)
TM helix 2 619..640 CDD:320570 14/20 (70%)
TM helix 3 649..671 CDD:320570 12/23 (52%)
TM helix 4 697..713 CDD:320570 7/15 (47%)
TM helix 5 745..768 CDD:320570 10/22 (45%)
TM helix 6 777..802 CDD:320570 19/24 (79%)
TM helix 7 812..837 CDD:320570 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I10450
eggNOG 1 0.900 - - E33208_3B9DN
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H654
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000883
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100392
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X509
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.710

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