DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and GRM7

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_870989.1	Gene:	GRM7 / 2917	HGNCID:	4599	Length:	922	Species:	Homo sapiens

Alignment Length:	925	Identity:	374/925 - (40%)
Similarity:	552/925 - (59%)	Gaps:	73/925 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 VEGDVILGGLMMVHSREDS-ITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDC 453
            :||||.||||..||::..| :.||.|..:.||..|||||:.:|:||.: .||||:||||.|||.|
Human    45 IEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTC 109

  Fly   454 DKDSYGLEMAVDFIKGSISNIDDAEYHCNK------TQVRKVISGVVGAASSVTSIQVANLLRLF 512
            .:|:|.||.::.|::..|.. |.::..|..      .:..||: ||:||:.|..||.|||:||||
Human   110 SRDTYALEQSLTFVQALIQK-DTSDVRCTNGEPPVFVKPEKVV-GVIGASGSSVSIMVANILRLF 172

  Fly   513 RIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEE 577
            :|||:||.||:||||:.:|:::|||.:|.|.:|.:|||:|||.:||:|||.:..|.:||.|..|.
Human   173 QIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVES 237

  Fly   578 LEELLAR-HNICIAIKEKLV---KDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRA 638
            ..::... ..:|||...::.   ||    ..|.:|.|:::||..|.:|..:||.:|::::|::.|
Human   238 FTQISKEAGGLCIAQSVRIPQERKD----RTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAA 298

  Fly   639 VRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPW 703
            .:||:..|.|.|:|||.|.::......:|...||.:::||:...|.||:.||.|.|:|||:||.|
Human   299 AKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVW 363

  Fly   704 FVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSR-QNTDFEDQLQFVSDAVMAFAYALRDMHR 767
            |.|:||::|.|:...|.|.. .:..::||.:||:.: .|.:.|.::|||.|||.|.|:||..|::
Human   364 FAEYWEENFNCKLTISGSKK-EDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNK 427

  Fly   768 DLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHW 832
            |||.....:|..|:...|..||||:|.|.|.|.:|....|:.|||.|.||:|..::.:......:
Human   428 DLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492

  Fly   833 VKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHP 897
            ..:|::|: ||:||:.::::.:...:.|.|||:|||..||.||..:|..|||.|..|..||.:.
Human   493 RLIGQWTD-ELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQF- 555

  Fly   898 DDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTP 962
             ||..|:.|.....|:.::..|:.||.|.|...|.||:..:..:..||:.|:|||..|:|:||||
Human   556 -DEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTP 619

  Fly   963 IVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQR--FGVGFCFTVVYAALLTKTNRIAR 1025
            |||||||||||:||.|||:||.:||.::.||...||:.:|  .|:|.|  :.|||||||||||.|
Human   620 IVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMC--ISYAALLTKTNRIYR 682

  Fly  1026 IFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY-------PTREDNLL 1083
            ||:.||:|...|..|||.|||.|.:.|:|||:|...:|..:.|.:.:..|       |.:...:|
Human   683 IFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVL 747

  Fly  1084 VCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGT 1148
            .|| ..|...:.:..|.|.|:|.|||||:.||.:||.|||:|.|||||||||::||||:|::|||
Human   748 KCD-ITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGT 811

  Fly  1149 ANHVP---LRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGP 1210
            |....   ::.|:::::::|||||.:..|:.||:|||:..||.||::
Human   812 AQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQK------------------ 858

  Fly  1211 SSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYAD 1275
            ......|||||||.:..   ..| .|::..|.....:|||             :::..|.||...
Human   859 RKRSFKAVVTAATMSSR---LSH-KPSDRPNGEAKTELCE-------------NVDPNNCIPPVR 906

  Fly  1276 QYVPNNATTATTTPT 1290
            :.|..:.|..|..||
Human   907 KSVQKSVTWYTIPPT 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	190/466 (41%)
		ANF_receptor	422..820	CDD:279440	169/409 (41%)
		NCD3G	861..910	CDD:284890	22/48 (46%)
		7tm_3	945..1181	CDD:278433	121/247 (49%)
GRM7	NP_870989.1	PBP1_mGluR_groupIII	47..511	CDD:107371	191/471 (41%)
		ANF_receptor	77..484	CDD:279440	170/413 (41%)
		Glutamate binding. /evidence=ECO:0000250	180..182		0/1 (0%)
		NCD3G	521..567	CDD:284890	22/47 (47%)
		7tm_3	602..847	CDD:278433	121/247 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..895		6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10450
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.710