DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and GRM6

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_000834.2	Gene:	GRM6 / 2916	HGNCID:	4598	Length:	877	Species:	Homo sapiens

Alignment Length:	870	Identity:	358/870 - (41%)
Similarity:	525/870 - (60%)	Gaps:	59/870 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDCDK 455
            |.:.||||..||:| .....||.:..:.|:..|||||:.:||:|.: :|||.:.|||.:||.|.:
Human    37 GGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSR 101

  Fly   456 DSYGLEMAVDFIKGSI---SNIDDAEYHC-------NKTQVRKVISGVVGAASSVTSIQVANLLR 510
            |:|.||.|:.|::..|   .:.|:....|       ......:|:: ||||::|..||.|||:||
Human   102 DTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVA-VVGASASSVSIMVANVLR 165

  Fly   511 LFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GI 572
            ||.|||:||.||:||||:..|:::|||.:|.|.||.:|||:||:.:||:|||.:..|.||   |:
Human   166 LFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGV 230

  Fly   573 KAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMR 637
            :||.::..  ....:|||...|:.::....|   :..::::|:..|.|||.|||.::.::|:|:.
Human   231 EAFVQISR--EAGGVCIAQSIKIPREPKPGE---FSKVIRRLMETPNARGIIIFANEDDIRRVLE 290

  Fly   638 AVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            |.|:||.||.|.|:|||.|.|:.......|....|.:::.|:...:.||::||::.::|||:||.
Human   291 AARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNI 355

  Fly   703 WFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMH 766
            ||.||||::|.|:.. |:.|..::.|::||.:||:.|.:| :.|.::|||.|||.|.|:||..||
Human   356 WFAEFWEENFNCKLT-SSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMH 419

  Fly   767 RDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFK----QSQA 827
            :.||.|...||.||:||.|..||:|:|.|.|.|.:|....|:.|||.|.||:|..::    .:.:
Human   420 QALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASS 484

  Fly   828 GQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTY 892
            |.|.  .||::.| .|||::..:::.....:.|.|:|||||..|:.||.|:|..|||||..|..|
Human   485 GGYQ--AVGQWAE-TLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGY 546

  Fly   893 QIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVR 957
              |...||..|:.|.....|..:...|||.|.:.|...|.||...:..:..||:.|..|:..|||
Human   547 --RFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVR 609

  Fly   958 HNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNR 1022
            :|:|||||||||||||:||.|||:.|.:||.:|.:|...|||.:|..:|...|:.|:||||||||
Human   610 YNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNR 674

  Fly  1023 IARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY-------PTRED 1080
            |.|||:.||:|...|.||||.|||||...|.|:|::....|:...|.|::..|       |.:..
Human   675 IYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQAR 739

  Fly  1081 NLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLY 1145
            .:|.|| ..|.|.:....|.:.|:|.|||||:..|.:||.|||:|.|||||||||:|||||||::
Human   740 GVLKCD-MSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 803

  Fly  1146 FGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAG 1207
            |||   |..:.::.|:::|::||||||::..|:.||.|:||..||:||::.
Human   804 FGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKR-------------- 854

  Fly  1208 TGPSSMMAAAVVTAATCAQEEKIQK 1232
              ..|:.|.:.|.|....::.:..|
Human   855 --KRSLKATSTVAAPPKGEDAEAHK 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	191/473 (40%)
		ANF_receptor	422..820	CDD:279440	171/412 (42%)
		NCD3G	861..910	CDD:284890	23/48 (48%)
		7tm_3	945..1181	CDD:278433	121/245 (49%)
GRM6	NP_000834.2	Periplasmic_Binding_Protein_Type_1	45..506	CDD:299141	186/470 (40%)
		ANF_receptor	67..476	CDD:279440	172/415 (41%)
		Glutamate binding. /evidence=ECO:0000250	175..177		0/1 (0%)
		NCD3G	515..562	CDD:284890	23/48 (48%)
		7tm_3	597..842	CDD:278433	121/245 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..877		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820