DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and GRM5

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001137303.1	Gene:	GRM5 / 2915	HGNCID:	4597	Length:	1212	Species:	Homo sapiens

Alignment Length:	1103	Identity:	399/1103 - (36%)
Similarity:	571/1103 - (51%)	Gaps:	111/1103 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 AIVEGDVILGGLMMVHSRE--DSI---TCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGA 447
            |.:.||:|:|.|..||.:.  |.:   .||.:..|.|||.:||||.|::|||.: .||||||||.
Human    29 AHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGC 93

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAE--YHC-----NKTQVRKVISGVVGAASSVTSIQV 505
            .|.|.|...:..||.:::||:.|:.:.::.|  ..|     :..:.:|.|.||:|..||..:|||
Human    94 EIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQV 158

  Fly   506 ANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY 570
            .|||:||.|||::|.:||.:||:|..|:||.|.:|||..|.:|||:||||..|:|||.::.|.||
Human   159 QNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNY 223

  Fly   571 GIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVRQ 634
            |....|..:::.|:..||||...|:..::|   :.::|.:::||.:. |:||....|.....||.
Human   224 GESGMEAFKDMSAKEGICIAHSYKIYSNAG---EQSFDKLLKKLTSHLPKARVVACFCEGMTVRG 285

  Fly   635 VMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQ 699
            ::.|:||....|.|..:|||||:.|..|:|.|:.|..|.::::.|:..|:.|::|:|.|..|.|.
Human   286 LLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNH 350

  Fly   700 RNPWFVEFWEDHFQCRYPGSTSTPYNN--YTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYAL 762
            |||||.|||:..||||..|   .|..|  |.|.|.:...|...:.. :.::.||.:|:.:.||.|
Human   351 RNPWFQEFWQHRFQCRLEG---FPQENSKYNKTCNSSLTLKTHHVQ-DSKMGFVINAIYSMAYGL 411

  Fly   763 RDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQA 827
            .:|...||.|...||:||||..|..||:.|.|..|.|:|||...||.|||.|.||.|::||:...
Human   412 HNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGK 476

  Fly   828 GQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTT 891
            ..:.::.||.:..|||:::..||..|:  .....||||.||..||.|...:|| ||||.|..|.
Human   477 DYFDYINVGSWDNGELKMDDDEVWSKK--SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCK- 538

  Fly   892 YQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFV 956
             :..:..||..||.|:||:.|......|..||..|||......|.|:.|:..|:|.||||..||:
Human   539 -ENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFI 602

  Fly   957 RHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTN 1021
            .:.|||:|::|.|||.||:||||.:.|..||.|:.||..|.|.:||.|:|....:.|:||:||||
Human   603 IYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTN 667

  Fly  1022 RIARIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLV 1084
            |||||....|:.  .|:|.|:|..:||||...|:.:|:.|.....::.|...||.||:..:..|:
Human   668 RIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLI 732

  Fly  1085 CDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTA 1149
            |:: .:...:....|...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:||| :
Human   733 CNT-TNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG-S 795

  Fly  1150 NHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMM 1214
            |:   :|.:|..::||||:|.:.|:|.||:||||.:||||||.:........||  .|.|.||..
Human   796 NY---KIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMH--VGDGKSSSA 855

  Fly  1215 AAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQYVP 1279
            |:                           ::..|..:..:..||..|         :.|.|:.:.
Human   856 AS---------------------------RSSSLVNLWKRRGSSGET---------LRYKDRRLA 884

  Fly  1280 NNATTATTTPTDKGS-GNGNSNSNSNTNGSSNSNSNSNGDGDVATEQVVANNNKINQRQHGQPAV 1343
            .:.:..... |.||| |||...:.|::||.|               ...|.|.|.::.||....:
Human   885 QHKSEIECF-TPKGSMGNGGRATMSSSNGKS---------------VTWAQNEKSSRGQHLWQRL 933

  Fly  1344 AFAITSTNNHISGPAATITTTAATGETTTEALVATITTPLATVDGSETMSVAPNNGHGNNGSQRP 1408
            :..|....|    |..|.........|.:..|.|..... .:..|......|...|.|..|.:.|
Human   934 SIHINKKEN----PNQTAVIKPFPKSTESRGLGAGAGAG-GSAGGVGATGGAGCAGAGPGGPESP 993

  Fly  1409 PVLQTNLXLNAQQLQQQLLKEQQRQQAELQTQHPQQQHGTQSSSSDTASTGSGSAAKKRAAIP 1471
            ......|                 ..||.:...|........|...|.|..:|||::....:|
Human   994 DAGPKALY----------------DVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVP 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	189/469 (40%)
		ANF_receptor	422..820	CDD:279440	168/408 (41%)
		NCD3G	861..910	CDD:284890	23/49 (47%)
		7tm_3	945..1181	CDD:278433	108/237 (46%)
GRM5	NP_001137303.1	PBP1_mGluR_groupI	26..497	CDD:107369	190/474 (40%)
		ANF_receptor	67..472	CDD:279440	169/411 (41%)
		NCD3G	508..557	CDD:284890	24/50 (48%)
		7tm_3	591..824	CDD:278433	108/237 (46%)
		GluR_Homer-bdg	1162..1212	CDD:287563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710