DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and GRM3

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_000831.2	Gene:	GRM3 / 2913	HGNCID:	4595	Length:	879	Species:	Homo sapiens

Alignment Length:	876	Identity:	360/876 - (41%)
Similarity:	530/876 - (60%)	Gaps:	42/876 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 VKREAIVEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINREQ-LLPNITLGA 447
            ::||..:|||::||||..::.: ..:..||.|....|||.||||||.||.||::. |||.:.||.
Human    29 LRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGV 93

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCN------KTQVRKVISGVVGAASSVTSIQVA 506
            ||||.|.:|:|.||.:::|::.|::.:|:|||.|.      :..:..:|:||:|.:.|..|||||
Human    94 HILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVA 158

  Fly   507 NLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYG 571
            ||||||:|||:||.|||.:||:|.|::||:||:|.|.||.|||.||::...|:|||.:..|.:||
Human   159 NLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYG 223

  Fly   572 IKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVM 636
            ....|..|:.....|||||..|| |..|.:.:  :||:::::||.||.||..::|....:.|:::
Human   224 ETGIEAFEQEARLRNICIATAEK-VGRSNIRK--SYDSVIRELLQKPNARVVVLFMRSDDSRELI 285

  Fly   637 RAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRN 701
            .|..||||  ||:|:.||||.|:..:....|....|.::::..:.|||.|:.||.||...||.||
Human   286 AAASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRN 348

  Fly   702 PWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMH 766
            |||.:|||..|||.....     .|:.:.|.....:...|.:.|.::.||.:||.|.|:||..|.
Human   349 PWFRDFWEQKFQCSLQNK-----RNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQ 408

  Fly   767 RDLCGGGPSLCEAMKPTKGADLLK-YLRKVEF-----EGLSGDEF-RFDGNGDGPARYNIIHFKQ 824
            |.||.....||:|||...|..|.| ||.|:.|     .....|.. :||..|||..|||:.:| |
Human   409 RTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNF-Q 472

  Fly   825 SQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNC 889
            :..|:|.::|||.:.| .|.|::..:.:.|.|  .|.|.||.||...:.|....|:.|||.|..|
Human   473 NVGGKYSYLKVGHWAE-TLSLDVNSIHWSRNS--VPTSQCSDPCAPNEMKNMQPGDVCCWICIPC 534

  Fly   890 TTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGV 954
            ..|:  :..||..|..|..|..|.|....|..:||.|:|.|.|||||.:..:..|.:.|..|:.|
Human   535 EPYE--YLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTV 597

  Fly   955 FVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTK 1019
            |::||:||:|:||||||.||||.|:.:.|.:||..:.||:.::||::|.|:|..|.:.|:|||||
Human   598 FIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTK 662

  Fly  1020 TNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVI-APSHAMHHYPTREDNLL 1083
            ||.|||||...|..|:||.||||.||:.||..|:.|||::..||::: ||....:....:.:.::
Human   663 TNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVI 727

  Fly  1084 VCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGT 1148
            :..:..|:|.:|:.:|.:.|:::|||||..|||.||.|||:|.|||||||||:|||||:|:::.|
Human   728 LKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVT 792

  Fly  1149 ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPS-S 1212
            ::...::.|:|.:::|||..|.:.|||:||::|||.:|::||....:   :.|....:|||.: |
Human   793 SSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRL---HLNRFSVSGTGTTYS 854

  Fly  1213 MMAAAVVTAATCAQEEKIQKHITPTNTENSL 1243
            ..:|:......|...|.:.      :|.:||
Human   855 QSSASTYVPTVCNGREVLD------STTSSL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	195/468 (42%)
		ANF_receptor	422..820	CDD:279440	174/411 (42%)
		NCD3G	861..910	CDD:284890	17/48 (35%)
		7tm_3	945..1181	CDD:278433	110/236 (47%)
GRM3	NP_000831.2	PBP1_mGluR_groupII	37..494	CDD:107370	195/468 (42%)
		ANF_receptor	67..469	CDD:279440	174/411 (42%)
		Glutamate binding. /evidence=ECO:0000250	172..174		0/1 (0%)
		NCD3G	506..554	CDD:284890	18/49 (37%)
		7tm_3	588..825	CDD:278433	110/236 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720