DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mtt and GRM1

DIOPT Version :9

Sequence 1:NP_001260806.1 Gene:mtt / 35832 FlyBaseID:FBgn0050361 Length:1472 Species:Drosophila melanogaster
Sequence 2:NP_001264993.1 Gene:GRM1 / 2911 HGNCID:4593 Length:1194 Species:Homo sapiens


Alignment Length:1121 Identity:409/1121 - (36%)
Similarity:593/1121 - (52%) Gaps:151/1121 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   389 AIVEGDVILGGLMMVH-----SREDSITCGPIMPQGGIQALEAMLFTIDRINREQ-LLPNITLGA 447
            |.::||||:|.|..||     .:.....||.|..|.|||.:|||..|:|:||.:. ||||||||:
Human    39 ARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGS 103

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKT----------QVRKVISGVVGAASSVTS 502
            .|.|.|...|..||.:::||:.|:.:|.|.:...|:.          :.:|.|:||:|..||..:
Human   104 EIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVA 168

  Fly   503 IQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEE 567
            |||.|||:||.|||::|.:||.:||:|..::||.|.:|||..|.:||::||||..|:|||.::.|
Human   169 IQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTE 233

  Fly   568 SNYGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQE 631
            .|||....:..:||.|:..:|||..:|:..::|   :.::|.:::||..: |:||..:.|.....
Human   234 GNYGESGMDAFKELAAQEGLCIAHSDKIYSNAG---EKSFDRLLRKLRERLPKARVVVCFCEGMT 295

  Fly   632 VRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVE 696
            ||.::.|:||....|.||.||||||:.|:.|.:.||.|..|.::::.|:..||.|::|||.|.::
Human   296 VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD 360

  Fly   697 NNQRNPWFVEFWEDHFQCRYPGS-TSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAY 760
            .|.|||||.|||:..||||.||. ...|  |:.:.||..|.| .:|...:.::.||.:|:.|.|:
Human   361 TNTRNPWFPEFWQHRFQCRLPGHLLENP--NFKRICTGNESL-EENYVQDSKMGFVINAIYAMAH 422

  Fly   761 ALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQS 825
            .|::||..||.|...||:||||..|:.||.:|.|..|.|:||:|..||..||.|.||:|::.:.:
Human   423 GLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYT 487

  Fly   826 QAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNC 889
            :|.:|.:|.||.:.||.  ||:.:.|.:........||||.|||.||.|...:|| ||||.|..|
Human   488 EANRYDYVHVGTWHEGV--LNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTAC 550

  Fly   890 TTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGV 954
            .  :..:..||..||.|.||..|:|....|.|||..||...:..:|.|:|||..||||||||..:
Human   551 K--ENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLI 613

  Fly   955 FVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTK 1019
            ||.:.|||:|::|.|||.||:|||||:.|...|.|:.|||...|.:||..||....:.|:||:||
Human   614 FVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTK 678

  Fly  1020 TNRIARIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNL 1082
            |||||||....|:.  .::|.|:|..:|::|.:.|:|||:.:....:::.|...:..||:.::..
Human   679 TNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVY 743

  Fly  1083 LVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFG 1147
            |:|:: .:...:....|...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:|||
Human   744 LICNT-SNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG 807

  Fly  1148 TANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSS 1212
             :|:   :|.:....:|||.:|.:.|:|:||:|||:.:||||||                     
Human   808 -SNY---KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVR--------------------- 847

  Fly  1213 MMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQY 1277
               :|..|:      :.::.|:                                       .|..
Human   848 ---SAFTTS------DVVRMHV---------------------------------------GDGK 864

  Fly  1278 VPNNATTATTTPTDKGSGNGNSNSNSNTNGSSNSNSNSNGDGDVATEQ----VVANNNKINQRQH 1338
            :|..:.|.......|.:|.||:||    ||.|.|.|...| |.|...|    .::.:.|.|:...
Human   865 LPCRSNTFLNIFRRKKAGAGNANS----NGKSVSWSEPGG-GQVPKGQHMWHRLSVHVKTNETAC 924

  Fly  1339 GQPAVAFAITSTNNHISGPAATI----TTTAATGETTTEALVATITTPLATVDGSETMSV---AP 1396
            .|.||...:|.:... ||.:.|.    |.|....|...:|.....:.|     ||.:|.|   .|
Human   925 NQTAVIKPLTKSYQG-SGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPP-----GSPSMVVHRRVP 983

  Fly  1397 NNGHGNNGSQRPPV------LQTNLXLNAQQLQQQLLKEQQRQQAELQTQHPQQQHGTQSSSSDT 1455
                  :.:..||:      .:|.|.|....|.:.|....|:||     |.|.||..........
Human   984 ------SAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQ-----QPPPQQKSLMDQLQGV 1037

  Fly  1456 ASTGSGSAAKKRAAIP 1471
            .|..|       .|||
Human  1038 VSNFS-------TAIP 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mttNP_001260806.1 Periplasmic_Binding_Protein_Type_1 73..>152 CDD:299141
PBP1_mGluR 393..847 CDD:107357 195/471 (41%)
ANF_receptor 422..820 CDD:279440 172/410 (42%)
NCD3G 861..910 CDD:284890 24/49 (49%)
7tm_3 945..1181 CDD:278433 104/237 (44%)
GRM1NP_001264993.1 PBP1_mGluR_groupI 36..510 CDD:107369 197/478 (41%)
ANF_receptor 77..485 CDD:279440 173/413 (42%)
Glutamate binding. /evidence=ECO:0000305 186..188 0/1 (0%)
NCD3G 521..570 CDD:284890 25/50 (50%)
7tm_3 604..837 CDD:278433 104/237 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 883..905 12/26 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1173
GluR_Homer-bdg 1144..1194 CDD:287563
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9DN
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100392
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.670

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