DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm4

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001277974.1	Gene:	Grm4 / 268934	MGIID:	1351341	Length:	912	Species:	Mus musculus

Alignment Length:	895	Identity:	380/895 - (42%)
Similarity:	550/895 - (61%)	Gaps:	58/895 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 QPQRHWPVKREAIVEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLL 440
            :|:.| |......::||:.||||..||.| .:...||.:..:.||..||||||.:||||.: .||
Mouse    33 KPKGH-PHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLL 96

  Fly   441 PNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNK------TQVRKVISGVVGAASS 499
            |||||||.|||.|.:|::.||.::.|::..|.. |..|..|..      |:..:|: ||:||:.|
Mouse    97 PNITLGARILDTCSRDTHALEQSLTFVQALIEK-DGTEVRCGSGGPPIITKPERVV-GVIGASGS 159

  Fly   500 VTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSII 564
            ..||.|||:||||:|||:||.||:|:||:..|:::|||.:|||.||.:|||:||:.:.|:|||.:
Mouse   160 SVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTL 224

  Fly   565 YEESNY---GIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIF 626
            ..|.:|   |::||  :::......:|||...|:.::....|   :|.|:::||....||..|||
Mouse   225 ASEGSYGESGVEAF--IQKSRENGGVCIAQSVKIPREPKTGE---FDKIIKRLLETSNARAIIIF 284

  Fly   627 GSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFL 691
            .::.::|:|:.|.||||.||.|.|:|||.|.:::......|...||.:::.|:...||||:.||.
Mouse   285 ANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRTSVRGFDRYFS 349

  Fly   692 SLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAV 755
            |.|::||:||.||.|||||:|.|:. ...:....::.|:||.:||:.:.:. :.|.::|||.|||
Mouse   350 SRTLDNNRRNIWFAEFWEDNFHCKL-SRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAV 413

  Fly   756 MAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNII 820
            .|..:||..||||||.|...||..|.|..|..||||:|.|.|.|::|:...|:.|||.|.||:|.
Mouse   414 YAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIY 478

  Fly   821 HFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWH 885
            .: |.:.|...:..:|.:|: .|.|.:..:::.....:.|.|:|||||..|:.||.|:|.:||||
Mouse   479 QY-QRRNGSAEYKVIGSWTD-HLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWH 541

  Fly   886 CFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLF 950
            |..||.||  :..|...||.|.....|..::..|:|||.:.|..:|.||:..:..:..||..|||
Mouse   542 CEPCTGYQ--YQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLF 604

  Fly   951 VMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAA 1015
            |:..|||:||||||:||||||||:||||||:||..||.::.:|....|:::|..:|...::.|||
Mouse   605 VVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAA 669

  Fly  1016 LLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY----- 1075
            ||||||||.|||:.||:|...|.||||.|||.|...|:|:|:|...||.|:.|||::..:
Mouse   670 LLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFVLISLQLLGICVWFVVDPSHSVVDFQDQRT 734

  Fly  1076 --PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIW 1138
              |.....:|.|| ..|.|.:....|.:.|:|.|||||:.||.:||.|||:|.|||||||||::|
Mouse   735 LDPRFARGVLKCD-ISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVW 798

  Fly  1139 LAFVPLYFGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYG 1200
            |||:|::|||   |:.:.::.|:::|::||||||::..|:.||:||||..||:||     |.|..
Mouse   799 LAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNV-----PKRKR 858

  Fly  1201 NMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCE 1250
            ::             .|||||||.:.:...:.:..|.....|    :|||
Mouse   859 SL-------------KAVVTAATMSNKFTQKGNFRPNGEAKS----ELCE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	197/465 (42%)
		ANF_receptor	422..820	CDD:279440	177/408 (43%)
		NCD3G	861..910	CDD:284890	24/48 (50%)
		7tm_3	945..1181	CDD:278433	123/245 (50%)
Grm4	NP_001277974.1	PBP1_mGluR_groupIII	43..508	CDD:380599	197/474 (42%)
		Glutamate binding. /evidence=ECO:0000250	180..182		0/1 (0%)
		NCD3G	516..566	CDD:369426	25/51 (49%)
		7tmC_mGluR4	586..912	CDD:320568	148/329 (45%)
		TM helix 1	586..611	CDD:320568	9/24 (38%)
		TM helix 2	623..644	CDD:320568	15/20 (75%)
		TM helix 3	653..677	CDD:320568	11/23 (48%)
		TM helix 4	699..719	CDD:320568	9/19 (47%)
		TM helix 5	749..775	CDD:320568	10/25 (40%)
		TM helix 6	783..806	CDD:320568	16/22 (73%)
		TM helix 7	816..841	CDD:320568	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10394
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.710