DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and Grm6

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_075209.1	Gene:	Grm6 / 24419	RGDID:	2747	Length:	871	Species:	Rattus norvegicus

Alignment Length:	854	Identity:	358/854 - (41%)
Similarity:	523/854 - (61%)	Gaps:	54/854 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDCDK 455
            |.:.||||..||:| .....||.:..:.|:..|||||:.:||:|.: :|||.:.|||.:||.|.:
  Rat    31 GGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSR 95

  Fly   456 DSYGLEMAVDFIKGSI---SNIDDAEYHC-------NKTQVRKVISGVVGAASSVTSIQVANLLR 510
            |:|.||.|:.|::..|   .:.|:|...|       ......:|:: ||||::|..||.|||:||
  Rat    96 DTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVA-VVGASASSVSIMVANVLR 159

  Fly   511 LFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GI 572
            ||.|||:||.||:||||:..|:::|||.:|.|.||.:|||:||:.:||:|||.:..|.||   |:
  Rat   160 LFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGV 224

  Fly   573 KAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMR 637
            :||.::..  ....:|||...|:.::....|   :..::::|:..|.|||.|||.::.::|:|:.
  Rat   225 EAFVQISR--EAGGVCIAQSIKIPREPKPGE---FHKVIRRLMETPNARGIIIFANEDDIRRVLE 284

  Fly   638 AVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            |.|:||.||.|.|:|||.|.::.....:.|.|..|.:::.|:...:.||::||::.::|||:||.
  Rat   285 ATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNI 349

  Fly   703 WFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMH 766
            ||.||||::|.|:.. |:....::.|::||.:||:.:.:. :.|.::|||.|||.|.|:||..||
  Rat   350 WFAEFWEENFNCKLT-SSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMH 413

  Fly   767 RDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFK----QSQA 827
            :.||.|...||.||:||.|..||.|:|.|.|.|.:|....|:.|||.|.||:|..::    .:.:
  Rat   414 QALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASS 478

  Fly   828 GQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTY 892
            |.|.  .||::.|. |||:|..:::.....:.|.|.|||||..|:.||.|:|..|||||..|..|
  Rat   479 GGYQ--AVGQWAEA-LRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGY 540

  Fly   893 QIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVR 957
              |...||..|:.|.....|..:...|||.|.:.|...|.||...:..:..||:.|..:|..|:|
  Rat   541 --RFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMR 603

  Fly   958 HNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNR 1022
            ||||||||||||||||:||.|||:.|.:||.:|.:|...:||.:|..:|...|:.|:||||||||
  Rat   604 HNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNR 668

  Fly  1023 IARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY-------PTRED 1080
            |.|||:.||:|...|.||||.|||||...|.|:|::....|:...|.|::..|       |.:..
  Rat   669 IYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQAR 733

  Fly  1081 NLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLY 1145
            .:|.|| ..|.|.:....|.:.|:|.|||||:..|.:||.|||:|.|||||||||:|||||||::
  Rat   734 GVLKCD-MSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 797

  Fly  1146 FGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAG 1207
            |||   |..:.::.|:::|::||||||::..|:.||.|:||..||:||::     |..::.:|
  Rat   798 FGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQK-----RKRSLKKT-- 855

  Fly  1208 TGPSSMMAA 1216
                |.|||
  Rat   856 ----STMAA 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	189/473 (40%)
		ANF_receptor	422..820	CDD:279440	169/412 (41%)
		NCD3G	861..910	CDD:284890	23/48 (48%)
		7tm_3	945..1181	CDD:278433	121/245 (49%)
Grm6	NP_075209.1	Periplasmic_Binding_Protein_Type_1	39..500	CDD:299141	185/470 (39%)
		ANF_receptor	61..470	CDD:279440	170/415 (41%)
		Glutamate binding. /evidence=ECO:0000250	169..171		0/1 (0%)
		NCD3G	510..556	CDD:284890	23/47 (49%)
		7tm_3	591..836	CDD:278433	121/245 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..871		5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10177
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720