DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm5

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_006229721.1	Gene:	Grm5 / 24418	RGDID:	2746	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	1099	Identity:	397/1099 - (36%)
Similarity:	566/1099 - (51%)	Gaps:	119/1099 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 AIVEGDVILGGLMMVHSRE--DSI---TCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGA 447
            |.:.||:|:|.|..||.:.  |.:   .||.:..|.|||.:||||.|::|||.: .||||||||.
  Rat    29 AHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGC 93

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAE--YHC----NKTQVRKVISGVVGAASSVTSIQVA 506
            .|.|.|...:..||.:::||:.|:.:.::.|  ..|    :..:.:|.|.||:|..||..:|||.
  Rat    94 EIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQ 158

  Fly   507 NLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYG 571
            |||:||.|||::|.:||.:||:|..|:||.|.:|||..|.:|||:||||..|:|||.::.|.|||
  Rat   159 NLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYG 223

  Fly   572 IKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVRQV 635
            ....|..:::.|:..||||...|:..::|   :.::|.:::||.:. |:||....|.....||.:
  Rat   224 ESGMEAFKDMSAKEGICIAHSYKIYSNAG---EQSFDKLLKKLRSHLPKARVVACFCEGMTVRGL 285

  Fly   636 MRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQR 700
            :.|:||....|.|..:|||||:.|..|:|.|:.|..|.::::.|:..|:.|::|:|.|..|.|.|
  Rat   286 LMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLR 350

  Fly   701 NPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDM 765
            ||||.|||:..||||..| .:...:.|.|.|.:...|...:.. :.::.||.:|:.:.||.|.:|
  Rat   351 NPWFQEFWQHRFQCRLEG-FAQENSKYNKTCNSSLTLRTHHVQ-DSKMGFVINAIYSMAYGLHNM 413

  Fly   766 HRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQY 830
            ...||.|...||:||||..|..||..|.|..|.|:|||...||.|||.|.||.|::||:.....:
  Rat   414 QMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYF 478

  Fly   831 HWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQI 894
            .::.||.:..|||:::..||..|:  .....||||.||..||.|...:|| ||||.|..|.  :.
  Rat   479 DYINVGSWDNGELKMDDDEVWSKK--NNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCK--EN 539

  Fly   895 RHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHN 959
            .:..||..||.|:||:.|......|..||..|||......|.|:.|:..|:|.||||..:|:.:.
  Rat   540 EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYR 604

  Fly   960 DTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIA 1024
            |||:|::|.|||.||:||||.:.|..||.|:.||..|.|.:||.|:|....:.|:||:|||||||
  Rat   605 DTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIA 669

  Fly  1025 RIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDS 1087
            ||....|:.  .|:|.|:|..:||||...|:.:|:.|.....::.|...||.||:..:..|:|::
  Rat   670 RILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNT 734

  Fly  1088 YIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHV 1152
             .:...:....|...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:||| :|:
  Rat   735 -TNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG-SNY- 796

  Fly  1153 PLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAA 1217
              :|.:|..::||||:|.:.|:|.||:||||.:||||||.:........||  .|.|.||..|:
  Rat   797 --KIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMH--VGDGKSSSAAS- 856

  Fly  1218 VVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQYVPNNA 1282
                                      ::..|..:..:..||..|         :.|.|:.:..:.
  Rat   857 --------------------------RSSSLVNLWKRRGSSGET---------LRYKDRRLAQHK 886

  Fly  1283 TTATTTPTDKGS-GNGNSNSNSNTNGSSNSNSNSNGDGDVATEQVVANNNKINQRQHGQPAVAFA 1346
            :..... |.||| |||...:.|::||.|               ...|.|.|..:.||....::..
  Rat   887 SEIECF-TPKGSMGNGGRATMSSSNGKS---------------VTWAQNEKSTRGQHLWQRLSVH 935

  Fly  1347 ITSTNNHISGPAATITTTAATGETTTEALVATITTPLATVDGSETMSVAPNNGHGN-----NGSQ 1406
            |....|    |..|.........|....       |.|...|.....||   |.||     .|..
  Rat   936 INKKEN----PNQTAVIKPFPKSTENRG-------PGAAAGGGSGPGVA---GAGNAGCTATGGP 986

  Fly  1407 RPPVLQTNLXLNAQQLQQQLLKEQQRQQAELQTQHPQQQHGTQSSSSDTASTGSGSAAK 1465
            .||...... .:.               ||.:...|........|...|.|..:|||.:
  Rat   987 EPPDAGPKALYDV---------------AEAEESFPAAARPRSPSPISTLSHLAGSAGR 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	187/466 (40%)
		ANF_receptor	422..820	CDD:279440	166/405 (41%)
		NCD3G	861..910	CDD:284890	23/49 (47%)
		7tm_3	945..1181	CDD:278433	107/237 (45%)
Grm5	XP_006229721.1	PBP1_mGluR_groupI	26..496	CDD:380597	188/471 (40%)
		NCD3G	507..557	CDD:400103	24/51 (47%)
		7tmC_mGluR5	577..826	CDD:320566	114/253 (45%)
		TM helix 1	578..602	CDD:320566	10/23 (43%)
		TM helix 2	614..635	CDD:320566	12/20 (60%)
		TM helix 3	644..666	CDD:320566	9/21 (43%)
		TM helix 4	694..710	CDD:320566	5/15 (33%)
		TM helix 5	735..758	CDD:320566	6/22 (27%)
		TM helix 6	770..792	CDD:320566	16/21 (76%)
		TM helix 7	795..820	CDD:320566	10/27 (37%)
		Herpes_BLLF1	<1013..>1171	CDD:282904	6/18 (33%)
		GluR_Homer-bdg	1154..1203	CDD:402304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.670