DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and Grm4

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_073157.2	Gene:	Grm4 / 24417	RGDID:	2745	Length:	912	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	384/906 - (42%)
Similarity:	554/906 - (61%)	Gaps:	65/906 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 LYAT-------QPQRHWPVKREAIVEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFT 430
            |||.       :|:.| |......::||:.||||..||.| .:...||.:..:.||..||||||.
  Rat    22 LYAPWVPSSLGKPKGH-PHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFA 85

  Fly   431 IDRINRE-QLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNK------TQVRK 488
            :||||.: .|||||||||.|||.|.:|::.||.::.|::..|.. |..|..|..      |:..:
  Rat    86 LDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEK-DGTEVRCGSGGPPIITKPER 149

  Fly   489 VISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIV 553
            |: ||:||:.|..||.|||:||||:|||:||.||:|:||:..|:::|||.:|||.||.:|||:||
  Rat   150 VV-GVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIV 213

  Fly   554 KRMGWSYVSIIYEESNY---GIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLL 615
            :.:.|:|||.:..|.:|   |::||  :::......:|||...|:.::....|   :|.|:::||
  Rat   214 RALKWNYVSTLASEGSYGESGVEAF--IQKSRENGGVCIAQSVKIPREPKTGE---FDKIIKRLL 273

  Fly   616 TKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQA 680
            ....|||.|||.::.::|:|:.|.||||.||.|.|:|||.|.:::......|...||.:::.|:.
  Rat   274 ETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKR 338

  Fly   681 NPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DF 744
            ..||||:.||.|.|::||:||.||.|||||:|.|:. ...:....::.|:||.:||:.:.:. :.
  Rat   339 MSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKL-SRHALKKGSHIKKCTNRERIGQDSAYEQ 402

  Fly   745 EDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDG 809
            |.::|||.|||.|..:||..||||||.|...||..|.|..|..||||:|.|.|.|::|:...|:.
  Rat   403 EGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNE 467

  Fly   810 NGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAK 874
            |||.|.||:|..: |.:.|...:..:|.:|: .|.|.:..:::.....:.|.|:|||||..|:.|
  Rat   468 NGDAPGRYDIYQY-QLRNGSAEYKVIGSWTD-HLHLRIERMQWPGSGQQLPRSICSLPCQPGERK 530

  Fly   875 KYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMA 939
            |.|:|.:|||||..||.||  :..|...||.|.....|..::..|:|||.:.|..:|.||:..:.
  Rat   531 KTVKGMACCWHCEPCTGYQ--YQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLF 593

  Fly   940 FSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFG 1004
            .:..||..||||:..|||:||||||:||||||||:||||||:||..||.::.:|....|:::|..
  Rat   594 LAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIF 658

  Fly  1005 VGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPS 1069
            :|...::.|||||||||||.|||:.||:|...|.||||.|||.|...|:|:|:|...||.|:.||
  Rat   659 LGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPS 723

  Fly  1070 HAMHHY-------PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHI 1127
            |::..:       |.....:|.|| ..|.|.:....|.:.|:|.|||||:.||.:||.|||:|.|
  Rat   724 HSVVDFQDQRTLDPRFARGVLKCD-ISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPI 787

  Fly  1128 GFTMYTTCVIWLAFVPLYFGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERN 1189
            ||||||||::||||:|::|||   |:.:.::.|:::|::||||||::..|:.||:||||..||:|
  Rat   788 GFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQN 852

  Fly  1190 VRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCE 1250
            |     |.|..::             .|||||||.:.:...:.:..|.....|    :|||
  Rat   853 V-----PKRKRSL-------------KAVVTAATMSNKFTQKGNFRPNGEAKS----ELCE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	198/465 (43%)
		ANF_receptor	422..820	CDD:279440	178/408 (44%)
		NCD3G	861..910	CDD:284890	24/48 (50%)
		7tm_3	945..1181	CDD:278433	123/245 (50%)
Grm4	NP_073157.2	Glutamate binding. /evidence=ECO:0000250	180..182		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810