DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm3

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_008760904.1	Gene:	Grm3 / 24416	RGDID:	2744	Length:	903	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	371/945 - (39%)
Similarity:	547/945 - (57%)	Gaps:	82/945 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 LMLPLSSADGSGKYLRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVHSR-EDS 409
            |||.|.|..    :|.||.|                |..::||..:|||::||||..::.: ..:
  Rat    10 LMLALFSKG----FLLSLGD----------------HNFMRREIKIEGDLVLGGLFPINEKGTGT 54

  Fly   410 ITCGPIMPQGGIQALEAMLFTIDRINREQ-LLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISN 473
            ..||.|....|||.||||||.||.||::. |||.:.||.||||.|.:|:|.||.:::|::.|::.
  Rat    55 EECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTK 119

  Fly   474 IDDAEYHCN------KTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRF 532
            :|:|||.|.      :..:..:|:||:|.:.|..|||||||||||:|||:||.|||.:||:|.|:
  Rat   120 VDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRY 184

  Fly   533 EYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEELLARHNICIAIKEKLVK 597
            :||:||:|.|.||.|||.||::...|:|||.:..|.:||....|..|:.....|||||..|| |.
  Rat   185 DYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEK-VG 248

  Fly   598 DSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLV 662
            .|.:.:  :||:::::||.||.||..::|....:.|:::.|..|.||  ||:|:.||||.|:..:
  Rat   249 RSNIRK--SYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNA--SFTWVASDGWGAQESI 309

  Fly   663 SDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNY 727
            ....|....|.::::..::|||.|:.||.||...||.|||||.:|||..|||.....     .|:
  Rat   310 VKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNK-----RNH 369

  Fly   728 TKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLK-Y 791
            .:.|.....:...|.:.|.::.||.:||.|.|:||..|.|.||.....||:|||...|..|.| |
  Rat   370 RQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEY 434

  Fly   792 LRKVEF-----EGLSGDEF-RFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEV 850
            |.|:.|     .....|.. :||..|||..|||:.:.:|: .|:|.::|||.:.| .|.|::..:
  Rat   435 LLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQT-GGKYSYLKVGHWAE-TLSLDVDSI 497

  Fly   851 KFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAH 915
            .:.|.|  .|.|.||.||...:.|....|:.|||.|..|..|:  :..||..|..|..|..|.|.
  Rat   498 HWSRNS--VPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYE--YLVDEFTCMDCGPGQWPTAD 558

  Fly   916 KQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIF 980
            ...|..:||.|::.|.|||||.:..:..|.|.|..|:.||::||:||:|:||||||.||||.|:.
  Rat   559 LSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVS 623

  Fly   981 MCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQ 1045
            :.|.:||..:.||:.::||::|.|:|..|.:.|:|||||||.|||||...|..|:||.||||.||
  Rat   624 LSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQ 688

  Fly  1046 LVICACLVSVQILINGVWMVI-APSHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTV 1109
            :.||..|:.|||::..||::: .|....:..|.:.:.:::..:..|:|.:|:.:|.:.|:::|||
  Rat   689 VFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTV 753

  Fly  1110 YAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACL 1174
            ||..|||.||.|||:|.|||||||||:|||||:|:::.|::...::.|:|.:::|||..|.:.||
  Rat   754 YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCL 818

  Fly  1175 FSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQ------------E 1227
            |:||::|:|.:|::||....:     :::|.:.:|          ||.|.:|            :
  Rat   819 FAPKVHIVLFQPQKNVVTHRL-----HLNRFSVSG----------TATTYSQYPPSKARPYPEAQ 868

  Fly  1228 EKIQKHITPTNTENSLKTKKLC---EMATQTISSI 1259
            ...|.|.|......|.....:|   |:...|.||:
  Rat   869 PTPQHHSTKRQASASTYVPTVCNGREVLDSTTSSL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	193/468 (41%)
		ANF_receptor	422..820	CDD:279440	173/411 (42%)
		NCD3G	861..910	CDD:284890	17/48 (35%)
		7tm_3	945..1181	CDD:278433	111/236 (47%)
Grm3	XP_008760904.1	PBP1_mGluR_groupII	33..494	CDD:380598	194/472 (41%)
		NCD3G	505..555	CDD:400103	19/51 (37%)
		7tmC_mGluR3	575..828	CDD:320564	118/252 (47%)
		TM helix 1	576..600	CDD:320564	10/23 (43%)
		TM helix 2	612..633	CDD:320564	11/20 (55%)
		TM helix 3	642..664	CDD:320564	11/21 (52%)
		TM helix 4	690..706	CDD:320564	6/15 (40%)
		TM helix 5	733..756	CDD:320564	9/22 (41%)
		TM helix 6	768..790	CDD:320564	16/21 (76%)
		TM helix 7	797..822	CDD:320564	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720