DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm2

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001099181.1	Gene:	Grm2 / 24415	RGDID:	2743	Length:	872	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	385/891 - (43%)
Similarity:	536/891 - (60%)	Gaps:	70/891 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 PVKREAIVEGDVILGGLMMVHSR----EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNI 443
            |.|:...:|||::||||..||.:    |:   |||:....|||.||||||.:|||||: .|||.:
  Rat    21 PAKKVLTLEGDLVLGGLFPVHQKGGPAEE---CGPVNEHRGIQRLEAMLFALDRINRDPHLLPGV 82

  Fly   444 TLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYH-------CNKTQVRKVISGVVGAASSVT 501
            .|||||||.|.||::.||.|:||::.|:|...|...|       ...:.....::||:|.:.|..
  Rat    83 RLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDV 147

  Fly   502 SIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYE 566
            |||||||||||:|||:||.|||.:||:|.|::||:||:|.|.:|.|||.||::...|:|||.:..
  Rat   148 SIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVAS 212

  Fly   567 ESNY---GIKAFEELEELLAR-HNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFG 627
            |.:|   ||:||    ||.|| .|||:|..||:.:....|   |::.:|:.||.||.||.|::|.
  Rat   213 EGDYGETGIEAF----ELEARARNICVATSEKVGRAMSRA---AFEGVVRALLQKPSARVAVLFT 270

  Fly   628 SDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLS 692
            ..::.|:::.|.:|.||  ||:|:.||||.|...|....|...||.::::..:.|:..|..||.|
  Rat   271 RSEDARELLAATQRLNA--SFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQS 333

  Fly   693 LTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQ--LQFVSDAV 755
            |...||.|||||.||||:.|.|.:          ..:.|...   |.:...||.:  :.||.:||
  Rat   334 LDPWNNSRNPWFREFWEERFHCSF----------RQRDCAAH---SLRAVPFEQESKIMFVVNAV 385

  Fly   756 MAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLK-YLRKVEFEGL-----SGDEFRFDGNGDGP 814
            .|.|:||.:|||.||.....||:||:|..|..|.| ::..|:|:..     :.||.|||..|||.
  Rat   386 YAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGI 450

  Fly   815 ARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKP-PESVCSLPCLVGQAKKYVE 878
            .||||..:.::.:|:|.:.|||.:.|| |.|:.:.:.:...|..| |.|.||.|||..:.|....
  Rat   451 GRYNIFTYLRAGSGRYRYQKVGYWAEG-LTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQP 514

  Fly   879 GESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSAT 943
            ||.|||.|..|..|:.|.  ||..|..|.||..|:|....|..:|:.|:|...|||:|.:..:..
  Rat   515 GEVCCWLCIPCQPYEYRL--DEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACL 577

  Fly   944 GILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFC 1008
            |.|.||||:|||||||.||:|:||||||.||||.|:|:||.:||..:.||:..||.::|.|:|..
  Rat   578 GALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTA 642

  Fly  1009 FTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVI-APSHAM 1072
            |:|.|:|||||||||||||...::.|:||.||||.||:.||..|:|.|:||...|:|: ||....
  Rat   643 FSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGK 707

  Fly  1073 HHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVI 1137
            ...|.|.:.:.:..::.|||.:.:.:|.:.||.:||:||..|||.||.|||:|.|||||||||:|
  Rat   708 ETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCII 772

  Fly  1138 WLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMP-PRYGN 1201
            ||||:|:::.|::...::.|:|.|::|||.||.:.|||:|||:|||.:|::||.....| .|:|:
  Rat   773 WLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGS 837

  Fly  1202 MHRTA----GTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSL 1243
            ....|    |.|..|.....|     |...|.:.      :|.:||
  Rat   838 AAPRASANLGQGSGSQFVPTV-----CNGREVVD------STTSSL 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	202/477 (42%)
		ANF_receptor	422..820	CDD:279440	178/417 (43%)
		NCD3G	861..910	CDD:284890	21/48 (44%)
		7tm_3	945..1181	CDD:278433	125/236 (53%)
Grm2	NP_001099181.1	PBP1_mGluR_groupII	26..480	CDD:380598	202/479 (42%)
		Glutamate binding. /evidence=ECO:0000250	166..168		0/1 (0%)
		NCD3G	496..546	CDD:400103	23/51 (45%)
		7tmC_mGluR2	566..819	CDD:320563	132/252 (52%)
		TM helix 1	567..591	CDD:320563	12/23 (52%)
		TM helix 2	603..624	CDD:320563	13/20 (65%)
		TM helix 3	633..655	CDD:320563	11/21 (52%)
		Important for interaction with HTR2A. /evidence=ECO:0000250	677..685		4/7 (57%)
		TM helix 4	681..697	CDD:320563	7/15 (47%)
		TM helix 5	724..747	CDD:320563	9/22 (41%)
		TM helix 6	759..781	CDD:320563	16/21 (76%)
		TM helix 7	788..813	CDD:320563	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720