DRSC/TRiP Functional Genomics Resources

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Protein Alignment mtt and Casr

DIOPT Version :9

Sequence 1:NP_001260806.1 Gene:mtt / 35832 FlyBaseID:FBgn0050361 Length:1472 Species:Drosophila melanogaster
Sequence 2:NP_001296567.1 Gene:Casr / 24247 RGDID:2277 Length:1079 Species:Rattus norvegicus


Alignment Length:1076 Identity:300/1076 - (27%)
Similarity:500/1076 - (46%) Gaps:136/1076 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   392 EGDVILGGLMMVH-----------SREDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNIT 444
            :||:|||||..:|           ||.:|:.|.....: |.:.|:||:|.|:.||.. .||||:|
  Rat    29 KGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFR-GFRWLQAMIFAIEEINSSPSLLPNMT 92

  Fly   445 LGAHILDDCDKDSYGLEMAVDFI-KGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANL 508
            ||..|.|.|:..|..||..:.|: :..|.:::..|: ||.::.......||||..|..|..||||
  Rat    93 LGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEF-CNCSEHIPSTIAVVGATGSGVSTAVANL 156

  Fly   509 LRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIK 573
            |.||.||||||.|:|..||||.:::.|.||||:|.:|..||.:|::...|::|..|..:.:||..
  Rat   157 LGLFYIPQVSYASSSRLLSNKNQYKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRP 221

  Fly   574 AFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRA 638
            ..|:..|.....:|||...| |:......|:|..   |.:::....|:..::|.|..::..:::.
  Rat   222 GIEKFREEAEERDICIDFSE-LISQYSDEEEIQQ---VVEVIQNSTAKVIVVFSSGPDLEPLIKE 282

  Fly   639 VRRANATGSFSWIGSDGWSARNLVS-DDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            :.|.|.||.. |:.|:.|::.:|:: .:|...|.||:....:|..:.||.|:...:....:..|.
  Rat   283 IVRRNITGRI-WLASEAWASSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNG 346

  Fly   703 WFVEFWEDHFQCRYPGSTSTP-----------------YNNYT---KQCTTKERLSRQNTDFED- 746
            :..||||:.|.|........|                 .|:.|   ..||..|.::...|.:.| 
  Rat   347 FAKEFWEETFNCHLQEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDY 411

  Fly   747 ---QLQF-VSDAVMAFAYALRDMHRDLCGGG---PSLCEAMKPTKGADLLKYLRKVEFEGLSGDE 804
               ::.: |..||.:.|:||:|::..|.|.|   ...|..:|..:...:||:||.:.|....|::
  Rat   412 EHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQ 476

  Fly   805 FRFDGNGDGPARYNIIHFKQS-QAGQYHWVKVGEYT----EGE-LRLNMTEVKFKRLSPKPPESV 863
            ..||..||....|:||::..| :.|...:.:||.|.    :|| |.:|..::.:...|.:.|.|.
  Rat   477 VTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSN 541

  Fly   864 CSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPD---AHKQYCRPI-P 923
            ||..|..|..|..:||| :||:.|..|...:.....|.:.|..|     ||   :::.:...| .
  Rat   542 CSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKC-----PDDFWSNENHTSCIAK 601

  Fly   924 EI-YLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTF 987
            || :|.....:.|....|:..||.:|.||:|||::..:||||:|:.|||||:||..:..|:..:.
  Rat   602 EIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSL 666

  Fly   988 ALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACL 1052
            ..:.:|.:..|.:::...|..|.:..:.:|.||||:..:|:|...::....:.....|.::....
  Rat   667 FFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLC 731

  Fly  1053 VSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDSYIDASYMIAFS---YPIFLIVICTVYAVLT 1114
            ..:||||..:|:..||..:..::.. ||.::....: :.|.|...|   |...|..||..:|..:
  Rat   732 TFMQILICIIWLYTAPPSSYRNHEL-EDEIIFITCH-EGSLMALGSLIGYTCLLAAICFFFAFKS 794

  Fly  1115 RKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASV-TIACLFSPK 1178
            ||:||.|||:|.|.|:|....::|::|:|.|..|....   ::::.|...|:||. .:||:|..|
  Rat   795 RKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF---VSAVEVIAILAASFGLLACIFFNK 856

  Fly  1179 LYIILIRPERNV----------------------RQSMMPPRYGNMHRTAGTGPSSMMAAAVVTA 1221
            :||||.:|.||.                      |.::...|..::..:.|:.|||.:::...:.
  Rat   857 VYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSSSLGGSTGSIPSSSISSKSNSE 921

  Fly  1222 ATCAQEE--KIQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQYVPNNATT 1284
            ....|.|  |.|:.::.|..|...:...|.....|             ..|.|...|.|...:.|
  Rat   922 DRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQ-------------QPQQPRCKQKVIFGSGT 973

  Fly  1285 AT-TTPTDKGSGNGNSNSNS---NTNGSSNSNSN------------SNGDGDVATEQVVANNNKI 1333
            .| :...|:...|..::.||   |:..:..||..            ::.|.::..::.......:
  Rat   974 VTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCADADSEMTIQETGLQGPMV 1038

  Fly  1334 NQRQ-------HGQPAVAFAITSTNNHISGPAATIT 1362
            ...|       ...||:..: ||.:..|||..:::|
  Rat  1039 GDHQPEMESSDEMSPALVMS-TSRSFVISGGGSSVT 1073

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mttNP_001260806.1 Periplasmic_Binding_Protein_Type_1 73..>152 CDD:299141
PBP1_mGluR 393..847 CDD:107357 155/501 (31%)
ANF_receptor 422..820 CDD:279440 132/428 (31%)
NCD3G 861..910 CDD:284890 16/49 (33%)
7tm_3 945..1181 CDD:278433 73/239 (31%)
CasrNP_001296567.1 Ligand-binding 1 (LB1). /evidence=ECO:0000250|UniProtKB:P41180 22..188 66/160 (41%)
PBP1_CaSR 33..530 CDD:380587 154/503 (31%)
Anion binding. /evidence=ECO:0000250|UniProtKB:P41180 66..70 1/4 (25%)
Ligand-binding 2 (LB2). /evidence=ECO:0000250|UniProtKB:P41180 189..324 35/139 (25%)
Anion binding. /evidence=ECO:0000250|UniProtKB:P41180 415..417 0/1 (0%)
NCD3G 538..591 CDD:400103 19/57 (33%)
Cysteine-rich (CR). /evidence=ECO:0000250|UniProtKB:P41180 542..612 21/74 (28%)
7tmC_CaSR 611..862 CDD:320409 79/255 (31%)
TM helix 1 612..636 CDD:320409 10/23 (43%)
TM helix 2 648..669 CDD:320409 8/20 (40%)
TM helix 3 678..700 CDD:320409 4/21 (19%)
TM helix 4 726..742 CDD:320409 4/15 (27%)
TM helix 5 769..792 CDD:320409 7/22 (32%)
TM helix 6 804..826 CDD:320409 7/21 (33%)
TM helix 7 831..856 CDD:320409 7/27 (26%)
Interaction with RNF19A. /evidence=ECO:0000250|UniProtKB:P41180 880..900 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 894..964 15/82 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9DN
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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