DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and mgl-1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001300387.1	Gene:	mgl-1 / 191707	WormBaseID:	WBGene00003232	Length:	952	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	343/928 - (36%)
Similarity:	526/928 - (56%)	Gaps:	88/928 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 PVKREAIVEGDVILGGLMMVHSR--EDSITCGPIMPQGGIQALEAMLFTIDRIN-REQLLPNITL 445
            |..|:..:.||:::||:..|||:  .....||.|....|:..:||||:.:|:|| :...|....|
Worm    45 PKVRQIRIPGDILIGGVFPVHSKSLNGDEPCGEIAETRGVHRVEAMLYALDQINSQNDFLRGYKL 109

  Fly   446 GAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHC--------NKTQVRKVISGVVGAASSVTS 502
            ||.|||.|...:|.|..::||::..|.:.:.::|.|        .|...:|.::.|||.:.|..|
Worm   110 GALILDSCSNPAYALNQSLDFVRDMIGSSEASDYVCLDGSDPNLKKQSQKKNVAAVVGGSYSSVS 174

  Fly   503 IQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEE 567
            :|:|||||||||.|||..||:.:||:|.|||||:||:|||.||..|||||..:..|||||::|..
Worm   175 VQLANLLRLFRIAQVSPASTNADLSDKNRFEYFARTVPSDDYQAMAMVEIAVKFKWSYVSLVYSA 239

  Fly   568 SNYGIKAFEELEELLARHNICIAIKEKLV-KDSGVAEDIAYDNIVQKLLTKPR--ARGAIIFGSD 629
            ..||....:..::...:..||||::|::. |.....|.|  :|:||||..:..  |...::|...
Worm   240 DEYGELGADAFKKEARKKGICIALEERIQNKKESFTESI--NNLVQKLQPEKNVGATVVVLFVGT 302

  Fly   630 QEVRQVMR--AVRRANATGS---FSWIGSDGWSARN--LVSDDYEPEVEGTLSVQPQANPVRGFE 687
            :.:..::|  |.|....:|:   ..|:.|:.|...|  ..:.|.....:|.:.:...:..|..||
Worm   303 EYIPDILRYTAERMKLTSGAKKRIIWLASESWDRNNDKYTAGDNRLAAQGAIVLMLASQKVPSFE 367

  Fly   688 EYFLSL--TVENNQRNPWFVEFWEDHFQCRY---PGSTSTPYNNYTKQCTTKERLSRQNTDFEDQ 747
            |||:||  ..|..:||.|..|.|:..::|.:   ||||::       :|...:: |.:..:.:|:
Worm   368 EYFMSLHPGTEAFERNKWLRELWQVKYKCEFDTPPGSTAS-------RCEDIKQ-STEGFNADDK 424

  Fly   748 LQFVSDAVMAFAYALRDMHRDLC-------------GGGPSLCEAMKPTKGADLLK-YLRKVEFE 798
            :|||.|||.|.|:.|:.|.:.:|             ...|.:|.||:...|:|..: ||.||.|.
Worm   425 VQFVIDAVYAIAHGLQSMKQAICPDDAIENHWISRYSKQPEICHAMQNIDGSDFYQNYLLKVNFT 489

  Fly   799 GLSGDEFRFDGNGDGPARYNIIHFK-----------QSQAGQYHWVKVGEYTEGELRLNMTEVKF 852
            .:.|..|||...|||||.|.|:.:|           ..::....:|::|.::|.    |:| :..
Worm   490 DIVGKRFRFSPQGDGPASYTILTYKPKSMDKKRRMTDDESSPSDYVEIGHWSEN----NLT-IYE 549

  Fly   853 KRLSPKP---PESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDA 914
            |.|...|   |.|||||||.:|..|:.::.|.|||.|..|..|:  :..:||||..|:.|..|..
Worm   550 KNLWWDPDHTPVSVCSLPCKIGFRKQLIKDEQCCWACSKCEDYE--YLINETHCVGCEQGWWPTK 612

  Fly   915 HKQYC--RPIPEI-YLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILL 976
            .::.|  ..:.:: |:|..|.:::.....:..||:.||||:.|:|.:|:||:|:|||||||||||
Worm   613 DRKGCFDLSLSQLKYMRWRSMYSLVPTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILL 677

  Fly   977 AGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFIS 1041
            ..:.|||.:||.|:.||:.|||||:|.|:||.|:.:|:|:..|||||.|||..  :||:||.|||
Worm   678 ISMIMCYCMTFVLLSKPSAIVCAIKRTGIGFAFSCLYSAMFVKTNRIFRIFST--RSAQRPRFIS 740

  Fly  1042 PKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVI 1106
            |.||:|:.|.|..||::.:.:|:.:.|....||||||:..:|.| :..|..::.:.:|..||||:
Worm   741 PISQVVMTAMLAGVQLIGSLIWLSVVPPGWRHHYPTRDQVVLTC-NVPDHHFLYSLAYDGFLIVL 804

  Fly  1107 CTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTI 1171
            ||.|||.|||:||.|||:|.|||:||||||:||:::..:|||.:...::.:|:.::||:||:|.:
Worm   805 CTTYAVKTRKVPENFNETKFIGFSMYTTCVVWLSWIFFFFGTGSDFQIQTSSLCISISMSANVAL 869

  Fly  1172 ACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMA---------AAVVTAATCAQE 1227
            ||:|||||:|||....:|||:...........|:.|...|.:.|         .|::|.:|  :.
Worm   870 ACIFSPKLWIILFEKHKNVRKQEGESMLNKSSRSLGNCSSRLCANSIDEPNQYTALLTDST--RR 932

  Fly  1228 EKIQKHITPTNTENSLKT 1245
            ...:|...||:|.::..|
Worm   933 RSSRKTSQPTSTSSAHDT 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	167/504 (33%)
		ANF_receptor	422..820	CDD:279440	151/435 (35%)
		NCD3G	861..910	CDD:284890	21/48 (44%)
		7tm_3	945..1181	CDD:278433	122/235 (52%)
mgl-1	NP_001300387.1	PBP1_mGluR	54..547	CDD:380585	169/507 (33%)
		NCD3G	560..610	CDD:369426	23/51 (45%)
		7tmC_mGluRs_group2_3	633..882	CDD:320600	125/251 (50%)
		TM helix 1	634..658	CDD:320600	7/23 (30%)
		TM helix 2	670..691	CDD:320600	13/20 (65%)
		TM helix 3	700..722	CDD:320600	10/21 (48%)
		TM helix 4	746..762	CDD:320600	5/15 (33%)
		TM helix 5	787..810	CDD:320600	9/22 (41%)
		TM helix 6	819..844	CDD:320600	15/24 (63%)
		TM helix 7	851..876	CDD:320600	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820