DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and mgl-2

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_492720.3	Gene:	mgl-2 / 172914	WormBaseID:	WBGene00003233	Length:	1035	Species:	Caenorhabditis elegans

Alignment Length:	1103	Identity:	351/1103 - (31%)
Similarity:	543/1103 - (49%)	Gaps:	148/1103 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 AIVEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINREQLLPNITLGAHILDD 452
            |.:.|::.:|.|..:|.: ..|.:||.|..|.|||..|..:.|:.::|.|  || ..||..|.|.
Worm    31 AEIHGEIQIGALFPIHRQIAGSESCGEIWEQYGIQRSEIAMLTVKQLNEE--LP-FKLGLSIRDS 92

  Fly   453 CDKDSYGLEMAVDFIKGSISNIDDAEY-HCNKTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQ 516
            |..:...:|..:.|::..::.....:. .|||..|..|  .|:|...|.::|.|.|||::|||||
Worm    93 CWTERIAMEQTIAFLREGVAQCSCCQTPGCNKKSVPVV--AVIGPGKSSSTIAVQNLLQVFRIPQ 155

  Fly   517 VSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEEL 581
            |.|.:|:|:||:|::|.||.|.:|||.:|.:|:..::....|:||:::|...|||.|.||.||:|
Worm   156 VGYSATTPDLSDKEQFGYFLRVVPSDVFQAQAINRLLHHYNWTYVAVLYSAGNYGEKGFESLEKL 220

  Fly   582 LARH--NICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVRQVMRAVRRAN 643
            :|..  ::|||..||:   ..:|.:..|..::.:|.:: .|.:..:.|.....:|...:|.:..
Worm   221 IAHRSSSVCIAYSEKI---KTLASEQEYRQVLTRLDSQNSRPQVVVCFCEGASMRMFFKAQKHL- 281

  Fly   644 ATGS-----FSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPW 703
            |.|.     |.|||||||:.||.|.:|.|.|.||:.|::..|..:.||.:|:.:|..|||..|||
Worm   282 ADGKMQMKRFQWIGSDGWADRNDVVEDLEEEAEGSFSIRIHAPKIPGFRQYYTALHPENNTMNPW 346

  Fly   704 FVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRD 768
            |.|||:..|.|::..|.....|...:.|:..|.|..|..: :.:|..|.:::...|..|:.|::|
Worm   347 FREFWQQKFNCQFAVSKEDKNNENIRICSGDENLDEQYKE-DPKLSQVINSIRVVALGLKAMYQD 410

  Fly   769 LCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFR----FDGNGDGPARYNIIHF------- 822
            .|....:||..|....|..|.:||..|.:    .|:|:    ||.|||.||.|:|:::
Worm   411 RCRDNSTLCTEMLSRNGTLLYEYLLNVTY----SDQFKQPVYFDRNGDPPAWYDILNYIGTKDLD 471

  Fly   823 -KQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHC 886
             ..::.|.:.  .:.:|...||.:....:.|.: :...||||||.||.:||.::  |..:|||.|
Worm   472 NPYNEVGSFK--SINDYGVEELDMTAKSMFFDK-TELLPESVCSRPCGIGQRQR--ETMACCWIC 531

  Fly   887 FNCTTYQIRHPDDETH-CKLCKLGTLPDAHKQYCRPIPEIYLRPE-SAWA----IGAMAFSATGI 945
            .:|  ..|::.:..|: |..|.||:.|:|::..|.     |:.|| .:|.    |.|:..:.|||
Worm   532 ESC--LDIQYVNKTTNQCMNCTLGSWPNANRTGCE-----YIIPEVVSWTSFGHILALVLAVTGI 589

  Fly   946 LVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFT 1010
            :.::..:.||:|||.||:|:::.||||||:|:|:..||.|:|||:..|:...|.|.|......|.
Worm   590 ITSMATLAVFLRHNSTPVVKSTTRELSYIILSGLVACYAVSFALLATPSTTSCFITRVIPPIAFA 654

  Fly  1011 VVYAALLTKTNRIARIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGV-----WMVIAP 1068
            |||:||||||||||||....|:.  .|:|.|::..||:||...||:||.:|.||     |    |
Worm   655 VVYSALLTKTNRIARILAGSKKRILTKKPRFLTTFSQVVITWILVAVQCVIVGVGLMRDW----P 715

  Fly  1069 SHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYT 1133
            ......|......:|.||:. ..|::|.|.:..|||.:||:||..||.:||.|||:|.||||||.
Worm   716 DATYAKYALPRKLILECDTE-TKSFLIPFFWDFFLITLCTLYAFKTRNLPENFNEAKFIGFTMYC 779

  Fly  1134 TCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQS----- 1193
            |.|:|:||:.|:.||.:    :...||.:.||||||.:|.||.|||||||:.||:|:|.|
Worm   780 TVVVWIAFLVLHMGTTH----KALVMSFSYSLSASVALALLFFPKLYIILMHPEKNIRASYTTTK 840

  Fly  1194 MMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCEMATQTISS 1258
            ::...:||......:........:..||.|..|.....|                    :.::..
Worm   841 LIRCHFGNSQAAYDSTSKQQHLGSKTTARTSVQSGSASK--------------------SSSMGG 885

  Fly  1259 IITSLDINAYNQIPYADQYVPNNATTATTTPTDKGSGNGNSNSNSNTNGSSNSNSNS------NG 1317
            .:|                    .|.:...|..:||.:....|......|..|.|.|      .|
Worm   886 GVT--------------------RTASVHVPVSRGSTHSTDVSTQTEAASKFSRSFSIVGRKKQG 930

  Fly  1318 -DGDVATEQVVANNNKINQRQHGQPAVAFAITSTNNHISGPAATITTTAATGETTTEALVATITT 1381
             |.||  :|:|....:....:....|....:..:.:.:             |....:::..::.|
Worm   931 LDDDV--QQLVDACRRYQDEKINSSAANLLLEESEDEV-------------GALLADSIENSMRT 980

  Fly  1382 PLATVDGSETMSVAPNNGHGNNGSQRP--PVLQTNLXLNAQQLQQQLLKEQQRQQAELQTQHP 1442
            .|:||.|...:.:.|         ..|  ||:.... .:.:...:|||:.:..|...|....|
Worm   981 VLSTVAGKAVVPLVP---------MVPMIPVVTLPTAPSQEDNFEQLLRSRGVQPLALSQATP 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	157/475 (33%)
		ANF_receptor	422..820	CDD:279440	141/410 (34%)
		NCD3G	861..910	CDD:284890	20/49 (41%)
		7tm_3	945..1181	CDD:278433	110/242 (45%)
mgl-2	NP_492720.3	Periplasmic_Binding_Protein_type1	28..482	CDD:385651	155/466 (33%)
		NCD3G	507..556	CDD:369426	22/52 (42%)
		7tmC_mGluR_group1	576..826	CDD:320412	117/258 (45%)
		TM helix 1	577..601	CDD:320412	7/23 (30%)
		TM helix 2	613..634	CDD:320412	13/20 (65%)
		TM helix 3	643..665	CDD:320412	11/21 (52%)
		TM helix 4	693..709	CDD:320412	8/15 (53%)
		TM helix 5	735..758	CDD:320412	9/23 (39%)
		TM helix 6	767..792	CDD:320412	16/24 (67%)
		TM helix 7	795..820	CDD:320412	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I1325
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.670