DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm8

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001298001.1	Gene:	Grm8 / 14823	MGIID:	1351345	Length:	908	Species:	Mus musculus

Alignment Length:	913	Identity:	388/913 - (42%)
Similarity:	564/913 - (61%)	Gaps:	81/913 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 VEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDC 453
            ::||:|||||..||:: |..:.||.:..:.||..|||||:.||:||:: .||.|||||..|||.|
Mouse    42 LDGDIILGGLFPVHAKGERGVPCGDLKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTC 106

  Fly   454 DKDSYGLEMAVDFIKGSISNIDDAEYHCNK------TQVRKVISGVVGAASSVTSIQVANLLRLF 512
            .:|:|.||.::.|::..|.. |.::..|..      |:..| ||||:|||:|..||.|||:||||
Mouse   107 SRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTKPDK-ISGVIGAAASSVSIMVANILRLF 169

  Fly   513 RIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GIKA 574
            :|||:||.||:||||:..|:::|||.:|.|.||.:|||:||..:||:|||.:..|.||   |::|
Mouse   170 KIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEA 234

  Fly   575 FEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAV 639
            |.::...:.  .:|||..:|:.::....|   ::.|:::||..|.||..|:|.::.::|:::.|.
Mouse   235 FTQISREIG--GVCIAQSQKIPREPRPGE---FEKIIKRLLETPNARAVIMFANEDDIRRILEAA 294

  Fly   640 RRANATGSFSWIGSDGWSARNLVSDDYEPE--VEGTLSVQPQANPVRGFEEYFLSLTVENNQRNP 702
            ::.|.:|.|.|||||.|.::  ::..|:.|  .||.:::.|:...:.||:.||.|.|:.||:||.
Mouse   295 KKLNQSGHFLWIGSDSWGSK--IAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNV 357

  Fly   703 WFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMH 766
            ||.||||::|.|:. ||.. ..|::.|:||..||::|.:: :.|.::|||.|||.:.||||.:||
Mouse   358 WFAEFWEENFGCKL-GSHG-KRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420

  Fly   767 RDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFK-QSQAGQY 830
            ::||.|...||..|....|.:||.|:|.|.|.|.:|....|:.|||.|.||:|..:: .:::.:|
Mouse   421 KELCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEY 485

  Fly   831 ----HWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCT- 890
                ||.       .:|.|.:.::::.......|.|||||||..|:.||.|:|..|||||..|.
Mouse   486 KIIGHWT-------NQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEG 543

  Fly   891 -TYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGV 954
             .||:    ||..|:||.|...|:.::..|:.||.|.|...|.||:..:..:..||:.|.||:..
Mouse   544 YNYQV----DELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVT 604

  Fly   955 FVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQR--FGVGFCFTVVYAALL 1017
            |||:|||||||||||||||:||.|||:||.:||.::..|..|:|:.:|  .|:|.||:  |||||
Mouse   605 FVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFS--YAALL 667

  Fly  1018 TKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY------- 1075
            ||||||.|||:.||:|...|.||||.|||||...|:|||:|...||.|:.|.|.:..|
Mouse   668 TKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLD 732

  Fly  1076 PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLA 1140
            |.....:|.|| ..|.|.:.:..|.|.|:|.|||||:.||.:||.|||:|.|||||||||:||||
Mouse   733 PENARGVLKCD-ISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLA 796

  Fly  1141 FVPLYFGTANHVP---LRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNM 1202
            |:|::||||....   ::.|:::|::||||||::..|:.||:|||:..||:||::
Mouse   797 FIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQK---------- 851

  Fly  1203 HRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCE-MATQTISSIITSLDIN 1266
                    ......||||||| .|.:.|||.....|.|  :|: :||| :.|.|.|:..|.:..:
Mouse   852 --------RKRSFKAVVTAAT-MQSKLIQKGNDRPNGE--VKS-ELCESLETNTSSTKTTYISYS 904

  Fly  1267 AYN 1269
            .::
Mouse   905 NHS 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	193/472 (41%)
		ANF_receptor	422..820	CDD:279440	173/410 (42%)
		NCD3G	861..910	CDD:284890	26/50 (52%)
		7tm_3	945..1181	CDD:278433	130/247 (53%)
Grm8	NP_001298001.1	PBP1_mGluR_groupIII	40..504	CDD:380599	193/479 (40%)
		Glutamate binding. /evidence=ECO:0000250	177..179		0/1 (0%)
		NCD3G	512..562	CDD:400103	27/53 (51%)
		7tmC_mGluR8	582..892	CDD:320570	157/334 (47%)
		TM helix 1	583..607	CDD:320570	8/23 (35%)
		TM helix 2	619..640	CDD:320570	14/20 (70%)
		TM helix 3	649..671	CDD:320570	12/23 (52%)
		TM helix 4	697..713	CDD:320570	7/15 (47%)
		TM helix 5	745..768	CDD:320570	10/22 (45%)
		TM helix 6	780..802	CDD:320570	16/21 (76%)
		TM helix 7	812..837	CDD:320570	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10394
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H654
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.710