DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_058672.1	Gene:	Grm1 / 14816	MGIID:	1351338	Length:	1199	Species:	Mus musculus

Alignment Length:	1126	Identity:	402/1126 - (35%)
Similarity:	574/1126 - (50%)	Gaps:	167/1126 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 AIVEGDVILGGLMMVH-----SREDSITCGPIMPQGGIQALEAMLFTIDRINREQ-LLPNITLGA 447
            |.::||||:|.|..||     .:.....||.|..|.|||.:|||..|:|:||.:. ||||||||:
Mouse    39 ARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGS 103

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKT----------QVRKVISGVVGAASSVTS 502
            .|.|.|...|..||.:::||:.|:.:|.|.:...|:.          :.:|.|:||:|..||..:
Mouse   104 EIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVA 168

  Fly   503 IQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEE 567
            |||.|||:||.|||::|.:||.:||:|..::||.|.:|||..|.:||::||||..|:|||.::.|
Mouse   169 IQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTE 233

  Fly   568 SNYGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQE 631
            .|||....:..:||.|:..:|||..:|:..::|   :.::|.:::||..: |:||..:.|.....
Mouse   234 GNYGESGMDAFKELAAQEGLCIAHSDKIYSNAG---EKSFDRLLRKLRERLPKARVVVCFCEGMT 295

  Fly   632 VRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVE 696
            ||.::.|:||....|.||.||||||:.|:.|.:.||.|..|.::::.|:..||.|::|||.|.::
Mouse   296 VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD 360

  Fly   697 NNQRNPWFVEFWEDHFQCRYPGS-TSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAY 760
            .|.|||||.|||:..||||.||. ...|  |:.|.||..|.| .:|...:.::.||.:|:.|.|:
Mouse   361 TNTRNPWFPEFWQHRFQCRLPGHLLENP--NFKKVCTGNESL-EENYVQDSKMGFVINAIYAMAH 422

  Fly   761 ALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQS 825
            .|::||..||.|...||:||||..|..||.:|.|..|.|:||:|..||..||.|.||:|::.:.:
Mouse   423 GLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYT 487

  Fly   826 QAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNC 889
            :|.:|.:|.||.:.||.  ||:.:.|.:........||||.|||.||.|...:|| ||||.|..|
Mouse   488 EANRYDYVHVGTWHEGV--LNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTAC 550

  Fly   890 TTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGV 954
            ...:.  ..||..|:.|.||..|:|....|.||...||......:|.|:|||..||||||||..:
Mouse   551 KENEF--VQDEFTCRACDLGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLI 613

  Fly   955 FVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTK 1019
            ||.:.|||:|::|.|||.||:|||||:.|...|.|:.|||...|.:||..||....:.|:||:||
Mouse   614 FVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTK 678

  Fly  1020 TNRIARIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNL 1082
            |||||||....|:.  .::|.|:|..:|::|.:.|:|||:.:....:::.|...:..||:.::..
Mouse   679 TNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVY 743

  Fly  1083 LVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFG 1147
            |:|:: .:...:....|...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:|||
Mouse   744 LICNT-SNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG 807

  Fly  1148 TANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSS 1212
             :|:   :|.:....:|||.:|.:.|:|:||:|||:.:||||||.:........||...|..|
Mouse   808 -SNY---KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLP-- 866

  Fly  1213 MMAAAVVTAATCAQEEKIQKHITPTNT-ENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQ 1276
                       |.           :|| .|..:.||
Mouse   867 -----------CR-----------SNTFLNIFRRKK----------------------------- 880

  Fly  1277 YVPNNATTATTTPTDKGSGNGNSNSNSNTNGSSNSNSNSNGDG-------DVATEQVVANNNKI- 1333
                           .|:||.|||..|.:...........|..       .|.|.:...|...:
Mouse   881 ---------------PGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVI 930

  Fly  1334 ----NQRQHGQPAVAFAITST-------------NNHISGPAATITTTAATGE--TTTEAL---V 1376
                ...|....::.|:..||             :.|.|.|::........|.  .||..|   :
Mouse   931 KPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPSMVVHRRGPPVATTPPLPPHL 995

  Fly  1377 ATITTPLATVDGSETMSVAPNNGHGNNGSQRPPVLQTNLXLNAQQLQQQLLKEQQRQQAELQTQH 1441
            :...|||...|     ||.|..        .||.|                 .||:||.  ..|.
Mouse   996 SAEETPLFLAD-----SVIPKG--------LPPPL-----------------PQQQQQP--PPQP 1028

  Fly  1442 PQQQHGTQSSSSDTASTGSGS 1462
            |.||..:.........|..||
Mouse  1029 PPQQPKSLMDQLQGVVTNFGS 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	196/471 (42%)
		ANF_receptor	422..820	CDD:279440	173/410 (42%)
		NCD3G	861..910	CDD:284890	23/49 (47%)
		7tm_3	945..1181	CDD:278433	104/237 (44%)
Grm1	NP_058672.1	PBP1_mGluR_groupI	36..510	CDD:380597	198/478 (41%)
		Glutamate binding. /evidence=ECO:0000250	186..188		0/1 (0%)
		NCD3G	521..571	CDD:400103	24/51 (47%)
		7tmC_mGluR1	591..840	CDD:320565	113/253 (45%)
		TM helix 1	592..616	CDD:320565	14/23 (61%)
		TM helix 2	628..649	CDD:320565	12/20 (60%)
		TM helix 3	658..680	CDD:320565	9/21 (43%)
		TM helix 4	708..724	CDD:320565	5/15 (33%)
		TM helix 5	749..772	CDD:320565	6/22 (27%)
		TM helix 6	784..806	CDD:320565	16/21 (76%)
		TM helix 7	809..834	CDD:320565	8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..906		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..1035		25/107 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1055..1082
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1177
		GluR_Homer-bdg	1150..1199	CDD:402304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.670