DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm6

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_775548.2	Gene:	Grm6 / 108072	MGIID:	1351343	Length:	871	Species:	Mus musculus

Alignment Length:	888	Identity:	366/888 - (41%)
Similarity:	530/888 - (59%)	Gaps:	81/888 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 GDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDCDK 455
            |.:.||||..||:| .....||.:..:.|:..|||||:.:||||.: :|||.:.|||.:||.|.:
Mouse    31 GGLTLGGLFPVHARGAAGRACGTLKKEQGVHRLEAMLYALDRINADPELLPGVRLGARLLDTCSR 95

  Fly   456 DSYGLEMAVDFIKGSISNIDDAEYHCNKTQVR--------------KVISGVVGAASSVTSIQVA 506
            |:|.||.|:.|::..|....|.|    :..||              :|:: ||||::|..||.||
Mouse    96 DTYALEQALSFVQALIRGRGDGE----EASVRCPGGVPPLRAAPPERVVA-VVGASASSVSIMVA 155

  Fly   507 NLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY- 570
            |:||||.|||:||.||:||||:..|:::|||.:|.|.||.:|||:||:.:||:|||.:..|.||
Mouse   156 NVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYG 220

  Fly   571 --GIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVR 633
              |::||.::..  ....:|||...|:.::....|   :..::::|:..|.|||.|||.::.::|
Mouse   221 ESGVEAFVQISR--EAGGVCIAQSIKIPREPKPGE---FHKVIRRLMETPNARGIIIFANEDDIR 280

  Fly   634 QVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENN 698
            :|:.|.|:||.||.|.|:|||.|.::.....:.|.|..|.:::.|:...:.||::||::.::|||
Mouse   281 RVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENN 345

  Fly   699 QRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYAL 762
            :||.||.||||::|.|:.. |:....::.|::||.:||:.:.:| :.|.::|||.|||.|.|:||
Mouse   346 RRNIWFAEFWEENFNCKLT-SSGGQSDDSTRKCTGEERIGQDSTYEQEGKVQFVIDAVYAIAHAL 409

  Fly   763 RDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFK---- 823
            ..||:.||.|...||.||:||.|..||.|:|.|.|.|.:|....|:.|||.|.||:|..::
Mouse   410 HSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG 474

  Fly   824 QSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFN 888
            .:.:|.|.  .||::.|. |||:|..:::.....:.|.|.|||||..|:.||.|:|..|||||..
Mouse   475 SASSGGYQ--AVGQWAEA-LRLDMEALQWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEA 536

  Fly   889 CTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMG 953
            |..|  |...||..|:.|.....|..:...|||.|.:.|...|.||...:..:..||:.|..::.
Mouse   537 CDGY--RFQVDEFTCEACPGHMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIIA 599

  Fly   954 VFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLT 1018
            .|:|||||||||||||||||:||.|||:.|.:||.:|.:|...|||.:|..:|...|:.|:||||
Mouse   600 TFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAVCASRRLLLGLGTTLSYSALLT 664

  Fly  1019 KTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY-------P 1076
            |||||.|||:.||:|...|.||||.|||||...|.|:|::....|:...|.|::..|       |
Mouse   665 KTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDP 729

  Fly  1077 TREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAF 1141
            .:...:|.|| ..|.|.:....|.:.|:|.|||||:..|.:||.|||:|.|||||||||:|||||
Mouse   730 EQARGVLKCD-MSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAF 793

  Fly  1142 VPLYFGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMH 1203
            ||::|||   |..:.::.|:::|::||||||::..|:.||.|:||..||:||::     |..::.
Mouse   794 VPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQK-----RKRSLK 853

  Fly  1204 RTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTK 1246
            :|      |.|||                   |..:|||...|
Mouse   854 KT------STMAA-------------------PPKSENSEDAK 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	192/477 (40%)
		ANF_receptor	422..820	CDD:279440	172/416 (41%)
		NCD3G	861..910	CDD:284890	23/48 (48%)
		7tm_3	945..1181	CDD:278433	121/245 (49%)
Grm6	NP_775548.2	PBP1_mGluR_groupIII	39..500	CDD:380599	188/474 (40%)
		Glutamate binding. /evidence=ECO:0000250	169..171		0/1 (0%)
		NCD3G	508..558	CDD:400103	24/51 (47%)
		7tm_GPCRs	578..850	CDD:421689	132/277 (48%)
		TM helix 1	578..603	CDD:410628	6/24 (25%)
		TM helix 2	615..636	CDD:410628	13/20 (65%)
		TM helix 3	645..667	CDD:410628	10/21 (48%)
		TM helix 4	693..709	CDD:410628	5/15 (33%)
		TM helix 5	741..764	CDD:410628	9/22 (41%)
		TM helix 6	773..798	CDD:410628	20/24 (83%)
		TM helix 7	808..833	CDD:410628	9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..871		10/47 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10394
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720