DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm5

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001137306.1	Gene:	Grm5 / 108071	MGIID:	1351342	Length:	1203	Species:	Mus musculus

Alignment Length:	1217	Identity:	408/1217 - (33%)
Similarity:	598/1217 - (49%)	Gaps:	195/1217 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 AIVEGDVILGGLMMVHSRE--DSI---TCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGA 447
            |.:.||:|:|.|..||.:.  |.:   .||.:..|.|||.:||||.|::|||.: .||||||||.
Mouse    29 AHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGC 93

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAE--YHC----NKTQVRKVISGVVGAASSVTSIQVA 506
            .|.|.|...:..||.:::||:.|:.:.::.|  ..|    :..:.:|.|.||:|..||..:|||.
Mouse    94 EIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQ 158

  Fly   507 NLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYG 571
            |||:||.|||::|.:||.:||:|..|:||.|.:|||..|.:|||:||||..|:|||.::.|.|||
Mouse   159 NLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYG 223

  Fly   572 IKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVRQV 635
            ....|..:::.|:..||||...|:..::|   :.::|.:::||.:. |:||....|.....||.:
Mouse   224 ESGMEAFKDMSAKEGICIAHSYKIYSNAG---EQSFDKLLKKLRSHLPKARVVACFCEGMTVRGL 285

  Fly   636 MRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQR 700
            :.|:||....|.|..:|||||:.|..|:|.|:.|..|.::::.|:..|:.|::|:|.|..|.|.|
Mouse   286 LMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLR 350

  Fly   701 NPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDM 765
            ||||.|||:..||||..| .:...:.|.|.|.:...|...:.. :.::.||.:|:.:.||.|.:|
Mouse   351 NPWFQEFWQHRFQCRLEG-FAQENSKYNKTCNSSLTLRTHHVQ-DSKMGFVINAIYSMAYGLHNM 413

  Fly   766 HRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQY 830
            ...||.|...||:||||..|..||..|.|..|.|:|||...||.|||.|.||.|::||:.....:
Mouse   414 QMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYF 478

  Fly   831 HWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQI 894
            .::.||.:..|||:::..||..|:  .....||||.||..||.|...:|| ||||.|..|.  :.
Mouse   479 DYINVGSWDNGELKMDDDEVWSKK--NNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCK--EN 539

  Fly   895 RHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHN 959
            .:..||..||.|:||:.|......|..||..|||......|.|:.|:..|:|.||||..:|:.:.
Mouse   540 EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYR 604

  Fly   960 DTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIA 1024
            |||:|::|.|||.||:||||.:.|..||.|:.||..|.|.:||.|:|....:.|:||:|||||||
Mouse   605 DTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIA 669

  Fly  1025 RIFKAGKQS--AKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDS 1087
            ||....|:.  .|:|.|:|..:||||...|:.:|:.|.....::.|...||.||:..:..|:|::
Mouse   670 RILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNT 734

  Fly  1088 YIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHV 1152
             .:...:....|...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:||| :|:
Mouse   735 -TNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG-SNY- 796

  Fly  1153 PLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMH-------------- 1203
              :|.:|..::||||:|.:.|:|.||:||||.:||||||.:........||
Mouse   797 --KIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSS 859

  Fly  1204 ---------------------RTA---------------GTGPSSMMAAAVVTAATCAQEEK--- 1229
                                 |.|               |.|..:.|:::...:.|.||.||
Mouse   860 SLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTR 924

  Fly  1230 -------IQKHITPTNTENSLKTKKLCEMATQTI------------------SSIITS------- 1262
                   :..||......|.....|....:|::.                  |:..|:
Mouse   925 GQHLWQRLSVHINKKENPNQTAVIKPFPKSTESRGQGAGAGGGSGPGAAGAGSAGCTATGGPEPP 989

  Fly  1263 -LDINAYNQIPYADQYVPNNATTATTTPTD-----KGSGNGNSNSNSNTNGSSNSNSNSNGDGDV 1321
             ....|...:..|::..|..|...:.:|..     .||. |.::.::.:..|..:..:|:..|.:
Mouse   990 DAGPKALYDVAEAEERFPAAARPRSPSPISTLSHLAGSA-GRTDDDAPSLHSETAARSSSSQGSL 1053

  Fly  1322 ATEQV-------VANNNKINQRQHG----------------------------------QPAVAF 1345
             .||:       .||..::|.....                                  ||..|.
Mouse  1054 -MEQISSVVTRFTANITELNSMMLSTAAAPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAI 1117

  Fly  1346 AITSTNNHISGPAATITT----TAATGETTTEALVATITTPLATVDGSETMSVAPNNGHGNNGSQ 1406
            .:|......:||:....|    .||.|:...|.||| :|.|....|..::.|..||:
Mouse  1118 EVTGGAQPATGPSPAQETPAGAEAAPGKPDLEELVA-LTPPSPFRDSVDSGSTTPNS-------- 1173

  Fly  1407 RPPVLQTNLXLNAQQLQQQLLKEQQRQQAELQTQHPQQQHGTQSSSS 1453
              ||.::.|.:.:......|:....                ||||||
Mouse  1174 --PVSESALCIPSSPKYDTLIIRDY----------------TQSSSS 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	187/466 (40%)
		ANF_receptor	422..820	CDD:279440	166/405 (41%)
		NCD3G	861..910	CDD:284890	23/49 (47%)
		7tm_3	945..1181	CDD:278433	107/237 (45%)
Grm5	NP_001137306.1	PBP1_mGluR_groupI	26..496	CDD:380597	188/471 (40%)
		Glutamate binding. /evidence=ECO:0000250	172..174		0/1 (0%)
		NCD3G	507..557	CDD:400103	24/51 (47%)
		7tmC_mGluR5	577..826	CDD:320566	114/253 (45%)
		TM helix 1	578..602	CDD:320566	10/23 (43%)
		TM helix 2	614..635	CDD:320566	12/20 (60%)
		TM helix 3	644..666	CDD:320566	9/21 (43%)
		TM helix 4	694..710	CDD:320566	5/15 (33%)
		TM helix 5	735..758	CDD:320566	6/22 (27%)
		TM helix 6	770..792	CDD:320566	16/21 (76%)
		TM helix 7	795..820	CDD:320566	10/27 (37%)
		Allosteric effector binding. /evidence=ECO:0000250	804..808		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..1054		26/163 (16%)
		PHA03247	<982..1186	CDD:223021	39/216 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1182		20/72 (28%)
		GluR_Homer-bdg	1154..1203	CDD:402304	16/75 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810